2008
DOI: 10.1080/09546630701387009
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An open‐label pilot study to evaluate the efficacy and tolerability of a silicone gel in the treatment of hypertrophic scars using clinical and ultrasound assessments

Abstract: Silicone gel sheets and intralesional corticosteroids are effective treatments for hypertrophic scars according to evidence studies. The aim of this study was to evaluate, both clinically and by ultrasound, the efficacy and tolerability of a topical self-drying silicone gel containing polysiloxane and silicone dioxide applied twice daily in eight hypertrophic scars. After 6 months all lesions showed evident clinical and/or ultrasound improvement, with a mean scar thickness reduction of 37% (range 20-54%). Alth… Show more

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Cited by 9 publications
(11 citation statements)
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“…Silicone gel sheeting has good evidence of efficacy, and it has now become part of the standard care practiced by plastic surgeons (4,16–18). However, there are several products containing silicone derivative in semi‐liquid gel form that has equivalent efficacy to traditional silicone gel sheeting (19,20). In addition, silicone derivative in this form is easy to use and there are fewer side effects compared to conventional silicone gel sheeting (21,22).…”
Section: Discussionmentioning
confidence: 99%
“…Silicone gel sheeting has good evidence of efficacy, and it has now become part of the standard care practiced by plastic surgeons (4,16–18). However, there are several products containing silicone derivative in semi‐liquid gel form that has equivalent efficacy to traditional silicone gel sheeting (19,20). In addition, silicone derivative in this form is easy to use and there are fewer side effects compared to conventional silicone gel sheeting (21,22).…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have shown that topical silicone gel has the potential to reduce linear scarring after surgical treatments, but its effectiveness on burn scars has not been investigated in a controlled trial. [13][14][15][16] We conducted a randomized, double-blinded, within-subject comparative, placebo-controlled trial to investigate the effectiveness of topical silicone gel in the treatment of scars resulting from a burn injury. Our working hypothesis was that topical silicone gel will induce the scar maturation process after burns by demonstrating a statistically significant reduction of scar characteristics in comparison with a placebo cream in time.…”
mentioning
confidence: 99%
“…High‐frequency ultrasound (≥20 MHz) represents a technique long used in clinical and experimental dermatology . The ultrasound device used in our study was a state‐of‐the art 22 MHz system that has been validated and used in the evaluation of aged skin, striae distensae, and atrophic acne scars before and after treatments …”
Section: Discussionmentioning
confidence: 99%
“…18,19 High-frequency ultrasound (≥20 MHz) represents a technique long used in clinical and experimental dermatology. [9][10][11][12][13][14][15][16] The ultrasound device used in our study was a state-of-the art 22 MHz system that has been validated and used in the evaluation of aged skin, striae distensae, and atrophic acne scars before and after treatments. [12][13][14]16 This study suggests that high-frequency ultrasound is a useful, noninvasive technique for accurate, precise assessment of acne scar type.…”
Section: Discussionmentioning
confidence: 99%
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