An open-label, randomized, parallel-group comparative study of the efficacy of sorghum bicolor extract in preoperative anemia

Tayo, Adetokunbo; Dosunmu, Adedoyin; Akinola, Oluwarotimi Ireti; Adewunmi, Adeniyi Abiodun; Oloyede, Olufemi A.; Akinbami, Akinsegun; Osikomaiya, Bodunrin; Makanjuola, Samira

doi:10.1016/j.nut.2016.05.005

Cited by 7 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-clinical studies have shown that SBJS increased RBC count, Hb content, and Packed Cell Volume (PCV) in rats and rabbits infected with trypanosomes 19,24 . Interestingly, some clinical studies have also established its efficacy in anaemic conditions 15,40,41 . In a randomized open-label clinical trial, it was reported that SBJS increased RBC count, Hb content, and PCV in women with pre-operative anaemic conditions without inducing significant changes in the white blood cell and platelet counts 41 .…”

Section: Potential Therapeutic Indications Of Sbjs In Anaemic Conditionsmentioning

confidence: 99%

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of Sorghum bicolor Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of Sorghum Plant

Adebesin,

Omogbiya,

Oluwole

et al. 2024

JNR

Self Cite

View full text Add to dashboard Cite

Globally, across different cultures, humans have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants have been strongly attributed to the presence of secondary metabolites, particularly polyphenols. The potential health benefits of the leaf sheaths of the West African variety of Sorghum bicolor-based Jobelyn Supplement (SBJS) have also been ascribed to its high contents of polyphenols. This systematic review seeks to synthetically harmonize findings from various experimental and clinical studies on the health benefits of SBJS in different disease conditions including arthritis, cancer, chronic viral infections, stroke, anaemia, and premature aging. A systematic search was conducted using three primary databases (PubMed, Europe PMC, and Cochrane Library), to identify published articles on therapeutic potentials of SBJS and ethnomedicinal surveys on the application of the West African variety of S. bicolor using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standard. The inclusion criteria were experimental and clinical studies conducted on SBJS and West African variety of S. bicolor; while ethnomedicinal surveys were on the therapeutic uses of the West African variety of S. bicolor published in the English language. The review provides valuable information suggesting that SBJS possesses pleiotropic therapeutic potentials in diverse pathological conditions through mechanisms relating to antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. The review also showed that SBJS contains several bioactive substances with polyvalent pharmacological potentials including modulation of pathological mechanisms involved in the mediation of aging and age-related diseases, such as arthritis, stroke, memory loss and cancer as well as chronic viral infections. Taken together, these findings further suggest the need for more robust studies (including disease-specific clinical trial programs) in order to replicate and validate the prior insights gleaned from previous investigations on SBJS.

show abstract

Section: Potential Therapeutic Indications Of Sbjs In Anaemic Conditionsmentioning

confidence: 99%

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of Sorghum bicolor Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of Sorghum Plant

Adebesin,

Omogbiya,

Oluwole

et al. 2024

JNR

Self Cite

View full text Add to dashboard Cite

show abstract

“…Pre-clinical studies have shown that SBSJ increased RBC count, Hb content, and packed cell volume (PCV) in rats and rabbits infected with trypanosomes [19,24]. Interestingly, some clinical studies have also established its efficacy in anaemic conditions [15,[40][41]. In a randomized open label clinical trial, it has been reported that SBSJ increased RBC count, Hb content, and PCV in women with pre-operative anaemic condition without inducing significant changes in the white blood cell and platelet counts [41].…”

Section: Therapeutic Indications Of Sbsj In Anaemic Conditionsmentioning

confidence: 99%

“…Interestingly, some clinical studies have also established its efficacy in anaemic conditions [15,[40][41]. In a randomized open label clinical trial, it has been reported that SBSJ increased RBC count, Hb content, and PCV in women with pre-operative anaemic condition without inducing significant changes in the white blood cell and platelet counts [41]. Indeed, the prophylactic importance of SBSJ in anaemia has been recognized beyond Nigeria [40,[42][43].…”

Section: Therapeutic Indications Of Sbsj In Anaemic Conditionsmentioning

confidence: 99%

“…The anti-inflammatory, antioxidant, and immunomodulatory effects of SBSJ [15,17,42] are strongly indicative of its anti-viral action against HIV/AIDs and COVID-19. Pre-clinical studies have shown that SBSJ up-regulates the expressions of chemokines and increases CD4 cell counts in cultured human monocytes and macrophages [41] which are known to be severely affected in HIV infection [17,95,100]. Specifically, Benson et al [17] have shown that SBSJ causes several-fold increases in the expression of chemokines (e.g., RANTES/CCL5, Mip-1a/CCL3, and MIP-1b/CCL4) known to inhibit HIV entry into CD4+ T-cells.…”

Section: Potential Of Sbsj In Chronic Viral Infectionsmentioning

confidence: 99%

See 1 more Smart Citation

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Okubena¹,

Adebesin²,

Omogbiya³

et al. 2022

Preprint

View full text Add to dashboard Cite

Across different cultures around the globe, human beings have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants can be strongly attributed to the presence of secondary metabolites, particularly polyphenols. The health-promoting effects of Sorghum bicolor supplement Jobelyn® (SBSJ) —a unique supplement derived from the leaf sheaths of a West African variety of Sorghum bicolor (L.) Moench—have also been ascribed to its high levels of polyphenols. This review seeks to gather and synthesize findings from various experimental and clinical studies on the health benefits of SBSJ in arthritis, cancer, chronic viral infections, stroke, anaemia, and aging. SBSJ has been reported to contain potent bioactive polyphenolic compounds with polyvalent biological activities, including antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. Moreover, the probable benefits of SBSJ in chronic viral infections (e.g., HIV/AIDS and COVID-19) have been attributed to its potent anti-inflammatory and immunomodulatory activities. As this supplement is increasingly becoming one of the fastest-selling herbal medicines in Nigeria, there is a need for more robust studies (including clinical trials) in order to replicate and validate the prior insights gleaned from experimental studies.

show abstract

“…White blood cells and platelet counts were reduced though not significantly and were within the normal ranges. 16 In separate studies SBLS was used on HIV patients to assess its potentials in preventing anemia originating from HIV infection. This was a pilot study conducted on 10 HIV subjects and surprisingly results showed that SBLS not only increased hemoglobin levels but also the CD4 count in antiretroviral naive patients (Table 1).…”

Section: Sbls Extract Role In Anemiamentioning

confidence: 99%

The West African Sorghum Bicolor Leaf Sheath Extract Jobelyn® and Its Diverse Therapeutic Potentials

Okubena¹,

Makanjuola²,

Ajonuma³

et al. 2017

Preprint

View full text Add to dashboard Cite

The West-African variety of Sorghum bicolor leaf sheath (SBLS) Jobelyn® is a natural remedy, which has gained international recognition for its anti-anaemic effect and energy boosting qualities in debilitating diseases. The widespread use of traditional medicine in the region usually confirms its safety, but not its efficacy or deep assessment of their pharmacological properties. The other major issue for herbal-based treatments is the lack of definite and complete information about the composition of the extracts. Despite limitations, efforts have been made in isolation and characterisation of active compounds in this specie of Sorghum showing various subclasses of flavonoids including apigeninidin, a stable 3-deoxyanthocyanidin and potential fungal growth inhibitor, which accounts for 84% of the total extract. Nonclinical in vitro and in vivo studies support previous indications that this variety of Sorghum bicolor possesses several biologically active compounds with potent antioxidant, anti-inflammatory, anti-aging and neuro-protective properties. Clinical studies show that SBLS has the ability to boost haemoglobin concentrations in anaemic conditions and most remarkably to increase CD4 count in HIV-positive patients. The multiple effects and high safety profiles of this extract may encourage its development as a therapeutic agent for the treatment of anemia, chronic inflammatory conditions or in the symptomatic management of HIV infections. This review describes the potential therapeutic aspects of SBLS extract and its potential benefits.

show abstract

An open-label, randomized, parallel-group comparative study of the efficacy of sorghum bicolor extract in preoperative anemia

Cited by 7 publications

References 33 publications

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of <i>Sorghum bicolor</i> Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of <i>Sorghum</i> Plant

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of <i>Sorghum bicolor</i> Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of <i>Sorghum</i> Plant

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

The West African <em>Sorghum Bicolor </em>Leaf Sheath Extract Jobelyn® and Its Diverse Therapeutic Potentials

Contact Info

Product

Resources

About

An open-label, randomized, parallel-group comparative study of the efficacy of sorghum bicolor extract in preoperative anemia

Cited by 7 publications

References 33 publications

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of <i>Sorghum bicolor</i> Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of <i>Sorghum</i> Plant

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of <i>Sorghum bicolor</i> Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of <i>Sorghum</i> Plant

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

The West African&nbsp;<em>Sorghum Bicolor </em>Leaf Sheath Extract Jobelyn&reg; and Its Diverse Therapeutic Potentials

Contact Info

Product

Resources

About

The West African <em>Sorghum Bicolor </em>Leaf Sheath Extract Jobelyn® and Its Diverse Therapeutic Potentials