An open‐label, single‐arm trial of the safety and efficacy of a novel preparation of glutathione as a skin‐lightening agent in <scp>F</scp>ilipino women

Handog, Evangeline B.; Datuin, Maria Suzanne L.; Singzon, Ivan A.

doi:10.1111/ijd.12999

Cited by 41 publications

(65 citation statements)

References 15 publications

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“…A total of 1,176 articles was found but four articles were included (Figure ) . Two studies were conducted in Thailand, while the other two were conducted in the Philippines . Three studies were RCTs with placebo control and the other was a single‐arm study .…”

Section: Resultsmentioning

confidence: 99%

“…Three studies investigated the effect of glutathione on skin color compared to placebo . The remaining study reported such effect of oral glutathione with no comparison . All studies used skin melanin index measured by Mexameter ® as the outcome.…”

Section: Resultsmentioning

confidence: 99%

“…Of three RCTs, one appeared to have high risk of bias because of the concern of multiple outcome measurement and data analysis, while the remaining studies had some concerning risks of bias because they did not report randomization and allocation concealment processes. One single‐arm study was deemed as having moderate risk of bias because the participants reported their outcome by themselves and concerning risks of bias due to selection of the reported results . (See Appendix )…”

Section: Resultsmentioning

confidence: 99%

“…[14][15][16][17] Two studies were conducted in Thailand, 14,17 while the other two were conducted in the Philippines. 15,16 Three studies were RCTs with placebo control 14,15,17 and the other was a single-arm study. 16 The age of the subjects in the included studies ranged from 18 to 50 years.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…15,16 Three studies were RCTs with placebo control 14,15,17 and the other was a single-arm study. 16 The age of the subjects in the included studies ranged from 18 to 50 years. Three studies included only female, while the other included any gender with 30% of male.…”

Section: Study Characteristicsmentioning

confidence: 99%

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The clinical effect of glutathione on skin color and other related skin conditions: A systematic review

Dilokthornsakul

Dhippayom

Dilokthornsakul

2019

J of Cosmetic Dermatology

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Summary Background Glutathione is one of agents which is commonly used to lighten skin color in Asia as a dietary supplement. Previous studies suggest its potential effect of glutathione on skin color. However, the clinical efficacy of glutathione in oral form is still questionable due to its limited absorption and bioavailability. Aim To determine the clinical effects of glutathione on skin color and related skin conditions. Patients/Methods A systematic review was conducted using PubMed, CINAHL, Scopus, EMBASE and Cochrane library were searched from inceptions to October 2017. All clinical studies evaluating the effect of glutathione on any skin effects in healthy volunteer were included. Results A total of four studies were included. Three studies were RCTs with placebo control, while one was a single‐arm trial. One study used topical form, while others used oral form of glutathione with 250 to 500 mg/day. We found that both oral glutathione with the dosage of 500 mg/day and topical 2.0% oxidized glutathione could brighten skin color in sun‐exposed area measured by skin melanin index. No significant differences in the reduction in skin melanin index were observed in sun‐protected area for any products. In addition, glutathione also has a trend to improve skin wrinkle, skin elasticity, and UV spots. Some adverse events but nonserious were reported. Conclusions Current evidence of the skin whitening effect of glutathione is still inconclusive due to the quality of included studies and inconsistent findings. However, there is a trend that glutathione might brighten skin color at skin‐exposed area.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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The clinical effect of glutathione on skin color and other related skin conditions: A systematic review

Dilokthornsakul

Dhippayom

Dilokthornsakul

2019

J of Cosmetic Dermatology

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A practical guide to over‐the‐counter treatments for hyperpigmentation

Jafry,

Guan,

Mohammad

2024

JEADV Clinical Practice

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Hyperpigmentation of the skin, defined as increased melanin in the epidermis, is a common condition associated with psychosocial impairment and decreased quality of life. Prescription options are often not covered by insurance and can be cost prohibitive. As such, many turn to over‐the‐counter (OTC) products for treatment. However, a plethora of options are available, which can be confusing. This review aims to evaluate the evidence for common ingredients found in OTC products for management of hyperpigmentation and provide guidance for optimal use to clinicians and consumers. To perform this review, a comprehensive literature search utilizing PubMed and Google Scholar was conducted to identify relevant studies on the clinico‐epidemiological aspects of hyperpigmentation, including postinflammatory hyperpigmentation (PIH), melasma and maturational hyperpigmentation, as well as on relevant OTC treatments. The efficacy and safety of OTC products were assessed based on available evidence, clinical trials and expert recommendations. Our results showed hyperpigmentation is more prevalent among individuals with darker skin types (Fitzpatrick skin phototypes III–VI). Due to limited insurance coverage and the high cost of prescription options, over‐the‐counter (OTC) treatments are widely used for managing postinflammatory hyperpigmentation (PIH). However, the lack of strict regulation by the US Food and Drug Administration (FDA) raises concerns about the safety and efficacy of these products. By critically evaluating the existing literature, this review offers practical, evidence‐based guidance for the selection and utilization of OTC products for the treatment of hyperpigmentation.

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Depigmenting Agents

Galappatthy¹,

Rathnayake²

2018

Updates in Clinical Dermatology

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An open‐label, single‐arm trial of the safety and efficacy of a novel preparation of glutathione as a skin‐lightening agent in Filipino women

Abstract: The authors conclude that the lozenge containing glutathione was safe and effective in lightening the skin of Filipino women.

Cited by 41 publications

References 15 publications

The clinical effect of glutathione on skin color and other related skin conditions: A systematic review

The clinical effect of glutathione on skin color and other related skin conditions: A systematic review

A practical guide to over‐the‐counter treatments for hyperpigmentation

Depigmenting Agents

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