An Open, Parallel, Comparative Evaluation of Amlodipine and Nitrendipine in the Monotherapeutic Treatment of Mild and Moderate Essential Hypertension

Englert, Rudolf; Beressem, P; E, von Manteuffel; Stafunsky, S; Kramar, Marija

doi:10.1097/00005344-199117001-00008

Cited by 3 publications

(2 citation statements)

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“…When compared with diltiazem, amlodipine was found to be equally well tolerated (Osterloh, 1989). In a study comparing amlodipine with nitrendipine the total number of adverse events was higher in the nitrendipine group, and statistically significant increases in heart rate were seen after 2 and 4 weeks of treatment (Englert, 1989).…”

Section: Discussionmentioning

confidence: 99%

A comparison of amlodipine with enalapril in the treatment of isolated systolic hypertension.

Webster

Fowler

Jeffers

et al. 1993

Brit J Clinical Pharma

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Hg (amlodipine) and 88 to 80 mm Hg (enalapril) (95% CI for the difference between the drugs -4.9, 7.6) after 8 weeks treatment. 5 Home blood pressure recordings confirmed these reductions in blood pressure, although there was no significant difference between treatments for the reductions in blood pressure. 6 Both drugs were reasonably well tolerated. The adverse events occurring most frequently in the amlodipine group were headache (2), peripheral oedema (5) and palpitations (2). The adverse events occurring most frequently in the enalapril group were headache (2), peripheral oedema (2), palpitations (2) and dizziness (3).

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Section: Discussionmentioning

confidence: 99%

A comparison of amlodipine with enalapril in the treatment of isolated systolic hypertension.

Webster

Fowler

Jeffers

et al. 1993

Brit J Clinical Pharma

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“…There is a need to establish drug regimens in moderate to severe hypertension that are safe, effective and well tolerated. Previous studies have shown that amlodipine is an effective antihypertensive agent in patients with mild to moderate hypertension when compared with placebo (Frick et al, 1988;Heber et al, 1989;Mroczek et al, 1988;Webster etal., 1987) and also when compared with atenolol (de Bruijn et al, 1988;Frischman et al, 1988), hydrochlorothiazide (Burris etal., 1988;Rofman, 1988), verapamil (Lorimer et al, 1988), nitrendipine (Englert, 1989) and captopril (Valasco et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

A comparison of amlodipine with enalapril in the treatment of moderate/severe hypertension.

Fowler

Webster

Lyons

et al. 1993

Brit J Clinical Pharma

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1. The safety and efficacy of amlodipine vs enalapril as monotherapy was evaluated in patients with moderate/severe hypertension (supine DBP 105‐125 mm Hg, SBP 140‐220 mm Hg). 2. After 2 weeks placebo treatment 31 patients were randomised by the technique of minimisation in an observer‐blind study to receive once daily treatment with either amlodipine (15 patients) 5‐10 mg, or enalapril (16 patients) 5‐20 mg for 8 weeks. The study design concluded with 2 weeks placebo treatment. In addition to clinic measurements, home blood pressure monitoring (Copal UA‐251) was performed during the study. 3. Clinic supine systolic blood pressure was reduced from 177 to 152 mm Hg (amlodipine) and 183 to 169 mm Hg (enalapril) (95% CI for the intergroup difference ‐ 22.1, 0.3, P = 0.06) after 8 weeks treatment. 4. Clinic supine diastolic blood pressure was reduced from 110 to 93 mm Hg (amlodipine) and 109‐102 mm Hg (enalapril) (95% CI for the intergroup difference ‐ 17.7, ‐2.7, P < 0.01) after 8 weeks treatment. 5. Home blood pressure recordings confirmed these reductions in blood pressure. Although the reduction in blood pressure was greater for the amlodipine treated group, the differences between treatments were not statistically significant. 6. Both drugs were reasonably well tolerated. The adverse events occurring most frequently in the amlodipine group were headache (5), peripheral oedema (3), upper respiratory infection (3) and anxiety (2). The adverse events occurring most frequently in the enalapril treated patients were headache (6), dizziness (3) and upper respiratory infection (2).

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Comparative Study of the Effects of Amlodipine and Nitrendipine on 24-Hour Blood Pressure Profile

Germanò

Ramponi

Caparra

et al. 1997

Clinical Drug Investigation

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An Open, Parallel, Comparative Evaluation of Amlodipine and Nitrendipine in the Monotherapeutic Treatment of Mild and Moderate Essential Hypertension

Cited by 3 publications

References 0 publications

A comparison of amlodipine with enalapril in the treatment of isolated systolic hypertension.

A comparison of amlodipine with enalapril in the treatment of isolated systolic hypertension.

A comparison of amlodipine with enalapril in the treatment of moderate/severe hypertension.

Comparative Study of the Effects of Amlodipine and Nitrendipine on 24-Hour Blood Pressure Profile

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