An Open, Randomised, Multicentre, Phase 3 Trial Comparing the Efficacy of Two Tamoxifen Schedules in Preventing Gynaecomastia Induced by Bicalutamide Monotherapy in Prostate Cancer Patients

Bedognetti, Davide; Rubagotti, Alessandra; Conti, Giario; Francesca, F.; Cobelli, Ottavio De; L, Canclini; Gallucci, Michele; Aragona, Francesco; Tonno, Pasquale Di; Cortellini, P.; Martorana, Giuseppe; Lapini, A.; Boccardo, Francesco

doi:10.1016/j.eururo.2009.05.019

Cited by 36 publications

(30 citation statements)

References 22 publications

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“…In one study of 37 patients treated with tamoxifen for adolescent gynecomastia, pain and size reduction were seen in all patients [9]. Tamoxifen has been successfully used as prophylaxis against the development of gynecomastia in adult patients receiving chemotherapy for prostatic cancer [14]. Although the specific aromatase inhibitor anastrozole has been advocated by some [15], recent randomized studies indicated a response similar to that achieved with placebo [12].…”

Section: Discussionmentioning

confidence: 96%

Treatment of adolescent gynecomastia

Laituri

Garey

Ostlie

et al. 2010

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 96%

Treatment of adolescent gynecomastia

Laituri

Garey

Ostlie

et al. 2010

Journal of Pediatric Surgery

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“…Although data about its effect on progression and survival are still lacking because of short follow-up periods, no studies have shown a negative effect on PSA levels [6,13,24,25,26,28]. …”

Section: Discussionmentioning

confidence: 99%

“…In a non-inferiority study, Bedognetti et al [25] tried out two different schedules of tamoxifen as prophylactic treatment for patients treated with bicalutamide. A total of 81 patients were recruited and received tamoxifen 20 mg daily; after 8 weeks of treatment, they were randomized to continue this schedule or to start a weekly administration of 20 mg tamoxifen.…”

Section: Therapymentioning

confidence: 99%

Multimodality Treatment of Gynecomastia in Patients Receiving Antiandrogen Therapy for Prostate Cancer in the Era of Abiraterone Acetate and New Antiandrogen Molecules

et al. 2012

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Gynecomastia is a pathological enlargement of male breasts due to hormonal imbalance and elevation of estrogens at the expense of testosterone. It is very important to diagnose this disease precociously because it can be the expression of different underlying pathologies. Besides genetic, chromosomal or chronic diseases, drugs often represent the principal cause of this hormonal disequilibrium. In the elderly population, antiandrogen therapy for prostate cancer frequently induces gynecomastia, thus negatively affecting the patients’ compliance to treatment because of physical and psychological discomfort deriving from this condition; gynecomastia can in fact be associated with severe breast pain, and it can modify how patients see their own body. During the past decades and even today, many different surgical, radiotherapeutic or clinical approaches have been proposed to prevent or treat this hypertrophy. This article focuses on gynecomastia associated with antiandrogen-based hormonal treatment and shortly reviews the currently most often used therapeutic options for preventing and treating this pathology.

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“…Tamoxifen has also been used successfully in this situation (43) and appears to be superior to both radiotherapy (44) and anastrozole (45,46). Daily administration of tamoxifen was shown to be more efficacious than weekly dosing (47).…”

Section: Therapymentioning

confidence: 97%

Approach to the Patient with Gynecomastia

Carlson

2011

The Journal of Clinical Endocrinology &Amp; Metabolism

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Gynecomastia is a common and sometimes distressing condition that may occur in males of all ages. Although most cases have benign causes and many are self-limited, male breast enlargement may also be a sign of underlying systemic disease or drug toxicity. Although rare, male breast cancer must also be considered in the differential diagnosis. A careful diagnostic evaluation should be pursued, tailored to the individual patient's circumstances. Treatment may include reassurance, medication, or surgery.

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An Open, Randomised, Multicentre, Phase 3 Trial Comparing the Efficacy of Two Tamoxifen Schedules in Preventing Gynaecomastia Induced by Bicalutamide Monotherapy in Prostate Cancer Patients

Cited by 36 publications

References 22 publications

Treatment of adolescent gynecomastia

Treatment of adolescent gynecomastia

Multimodality Treatment of Gynecomastia in Patients Receiving Antiandrogen Therapy for Prostate Cancer in the Era of Abiraterone Acetate and New Antiandrogen Molecules

Approach to the Patient with Gynecomastia

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