An open trial of climatotherapy at the dead sea for patch-stage mycosis fungoides

Hodak, Emmilia; Gottlieb, Alice B.; Segal, T; Maron, Lea; Lotem, M; Feinmesser, Meora; David, Michael

doi:10.1016/j.jaad.2003.11.052

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…The therapeutic and cosmetic properties of Dead Sea (DS) mud and water have been well established, especially when combined with irradiation by atmosphere‐filtered sun rays at low‐altitude (18–21). Their unique composition is specially rich in magnesium, calcium, sodium, potassium, zinc and strontium (22,23), some of which are known to influence metabolism.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of a cream containing Dead Sea minerals against UVB‐induced stress in human skin

Portugal-Cohen¹,

Soroka²,

Ma’or

et al. 2009

Experimental Dermatology

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Section: Introductionmentioning

confidence: 99%

Protective effects of a cream containing Dead Sea minerals against UVB‐induced stress in human skin

Portugal-Cohen¹,

Soroka²,

Ma’or

et al. 2009

Experimental Dermatology

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“…In our study natural mineral extract supernatant was composed of ionized minerals. Several research reports have described that bathing in Dead Sea benefitted skin by improving skin barrier function, increasing stratum corneum hydration, reducing skin roughness and inflammation [22], and dramatically reducing the inflammation in psoriasis [23]. All of these processes are, to various extents, relevant to the condition of aged skin.…”

Section: Discussionmentioning

confidence: 99%

Anti-aging and anti-inflammation effects of natural mineral extract on skin keratinocytes

Jung

Seo

Youn

et al. 2009

Biotechnol Bioproc E

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In this study, we investigated the effects of a natural mineral extract on damaged skin keratinocytes. We have focused on the possible effects of the natural mineral extract on UV-irradiated normal human skin keratinocytes. Human keratinocytes were UV-irradiated and were treated with 0.1, 1.0, or 10% of natural mineral extract. Study controls included non-UV-irradiated cells, UV-irradiated cells (no extract), and UV-irradiated cells treated with 25 nM ascorbic acid. Cell viability following UV irradiation was significantly higher in the groups treated with the natural mineral extract at doses of 0.1, 1.0, and 10% than in the control group with UV irradiation only. The UV-irradiated cells demonstrated increased secretion of laminin relative to non-irradiated controls. We found that treating these UV-irradiated keratinocytes with natural mineral extract reduced vacuole size and number, and it dose-dependently increased laminin secretion and reduced IL-2 synthesis. Also, MMP-1 and MMP-2 activity were significantly less in cells treated with natural mineral extract than in UV-irradiated controls. The UV irradiation reduced MMP-1 levels to 45±5 ng/mL from 130± 5 ng/mL. In addition, MMP-2 production in keratinocytes was significantly reduced by 11±1 ng/mL compared to the UV-irradiation control. In conclusion, the results of this work suggest that natural mineral extract has effects on keratinocytes damaged by UV exposure. © KSBB hÉóïçêÇëW=~ÅíáåçãóÅáå=ãáåÉê~äI=âÉê~íáåçÅóíÉI=rs=áêê~Çá~íáçåI=ÅóíçâáåÉ= = = = =

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“…Eine katamnestische Untersuchung des medizinischen Dienstes [71] zeigte allerdings, dass die nach dem Aufenthalt am Toten Meer entstandenen Repigmentierungen nach einiger Zeit wieder verblassen. Auch bei Mycosis fungoides wurden längerfristige (5 Monate) anhaltende Erfolge publiziert [72].…”

Section: Hauterkrankungen: Psoriasis Vitiligounclassified

Die Evidenz der Klima- und Thalassotherapie. Ein Review

Schuh¹

2009

Schweiz Z Ganzheitsmed

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Hintergrund: Klimatherapie (am Meer: Klima- und Thalassotherapie) wird seit langer Zeit zur Behandlung zahlreicher Krankheitsbilder, insbesondere von Haut- und Atemwegserkrankungen, eingesetzt. Ziel und Fragestellung: FÜr welche Krankheitsbilder ist die Evidenz gesichert? Methode: Systematische Auswertung der wissenschaftlichen Literatur der gÄngigen Datenbanken von 1988 bis 2008. Ergebnisse: Die einzelnen Wirkfaktoren der Klimatherapie sind evident. FÜr die Klimatherapie von atopischen Erkrankungen (Neurodermitis, Asthma bronchiale) und Trainingsmangel im Hochgebirge sind eindeutige Daten Über akute und langfristige Erfolge vorhanden. Bei der Psoriasis ist grÖsste Evidenz fÜr die Therapie im Hochgebirgsklima sowie fÜr die Klima- und Thalassotherapie am Toten Meer gegeben. Auch bei weiteren Indikationen der Klimatherapie, wie den «funktionellen» StÖrungen des Herz-Kreislaufsystems, sprechen die Studienergebnisse fÜr eine anhaltende Reduzierung der Symptome, vor allem im Bereich des Hochgebirgsklimas. FÜr die AbhÄrtung an der See liegen genÜgend Daten vor. Trotzdem sind die therapeutischen Effekte der Klima- und Thalassotherapie noch verhÄltnismÄssig unsicher, vor allem fÜr die am meisten bekannten Indikationen Psoriasis, Neurodermitis und Asthma bronchiale. Schlussfolgerung: FÜr die meisten bekannten Indikationen der Klimatherapie und zum Teil der Thalassotherapie ist Evidenz fÜr akute und langfristige Effekte vorhanden. Voraussetzung ist die Wahl der richtigen Klimazone.

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An open trial of climatotherapy at the dead sea for patch-stage mycosis fungoides

Cited by 13 publications

References 30 publications

Protective effects of a cream containing Dead Sea minerals against UVB‐induced stress in human skin

Protective effects of a cream containing Dead Sea minerals against UVB‐induced stress in human skin

Anti-aging and anti-inflammation effects of natural mineral extract on skin keratinocytes

Die Evidenz der Klima- und Thalassotherapie. Ein Review

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