An optimised electrode pre-treatment for SAM formation on polycrystalline gold

Tkac, Jan; Davis, Jason J.

doi:10.1016/j.jelechem.2008.04.010

Cited by 90 publications

(91 citation statements)

References 44 publications

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“…The electrochemical method was used to testify the well-polishment. The cyclic voltammograms from 0 to 1.5 V at 0.1 V/s in 1 M H 2 SO 4 obtained at the well-polished bare gold electrode were shown in Fig S2 in supporting information. With the increasing numbers of scan cycles, the cyclic voltammetry curves gradually stabilized, and there was a broad anodic peak with peak potential of around 1.2 V and a single sharp reduction peak with peak potential between 0.9 and 1.0 V, which was consistent with the typical gold electrode cyclic voltammograms (Tkac and Davis, 2008), indicating that the gold disk electrode was correctly pretreated to composite the rest materials.…”

Section: Characterization Of the Composite Film Modified Gold Disk Elsupporting

confidence: 76%

“…Therefore, thiols were designed and modified at the terminals of B, C and D DNA strands to form the thiol-DNA tetrahedrons, which can anchor strongly and readily on gold surface (Pei et al, 2013). Meanwhile, the subsequent exposure of a pristine gold surface and the reliable removal of contaminants inherent on ambient surfaces sensitively affect the ability of fabricating high-quality self-assembled layers (Tkac and Davis, 2008). So the gold disk electrode needs to be well polished before the electrochemical deposition of gold nanoparticles.…”

Section: Characterization Of the Composite Film Modified Gold Disk Elmentioning

confidence: 99%

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An electrochemical biosensor based on DNA tetrahedron/graphene composite film for highly sensitive detection of NADH

Liu

et al. 2015

Biosensors and Bioelectronics

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Section: Characterization Of the Composite Film Modified Gold Disk Elsupporting

confidence: 76%

Section: Characterization Of the Composite Film Modified Gold Disk Elmentioning

confidence: 99%

An electrochemical biosensor based on DNA tetrahedron/graphene composite film for highly sensitive detection of NADH

Liu

et al. 2015

Biosensors and Bioelectronics

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“…Polycrystalline gold disk electrodes (GDE) (Cypress Gold, diameter 1 mm) were cleaned following a published procedure 9 and immersed in a 1 mM octanethiol (CH 2 ) 8 and dodecanethiol (CH 2 ) 12 (Sigma-Aldrich) solution in HPLCpure ethanol (overnight, room temperature). Electrodes were then rinsed with ethanol and water and dried under nitrogen.…”

Section: ■ Experimental Proceduresmentioning

confidence: 99%

Elucidating Capacitance and Resistance Terms in Confined Electroactive Molecular Layers

2012

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Electrochemical analyses on confined electroactive molecular layers, herein exemplified with electroactive self-assembled monolayers, sample current contributions that are significantly influenced by additional nonfaradaic and uncompensated resistance effects that, though unresolved, can strongly distort redox analysis. Prior work has shown that impedance-derived capacitance spectroscopy approaches can cleanly resolve all contributions generated at such films, including those which are related to the layer dipolar/electrostatic relaxation characteristics. We show herein that, in isolating the faradaic and nonfaradaic contributions present within an improved equivalent circuit description of such interfaces, it is possible to accurately simulate subsequently observed cyclic voltammograms (that is, generated current versus potential patterns map accurately onto frequency domain measurements). Not only does this enable a frequency-resolved quantification of all components present, and in so doing, a full validation of the equivalent circuit model utilized, but also facilitates the generation of background subtracted cyclic voltammograms remarkably free from all but faradaic contributions.

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“…Polycrystalline gold electrode surface was treated as described previously, namely using electrochemical reductive desorption, mechanical polishing, chemical treatment and once again electrochemical polishing and gold oxide stripping procedure [41]. Shortly, in the first step previously bound thiol molecules were desorbed from the surface using cyclic voltammetry (CV) in 100 mM NaOH under anaerobic conditions (100 scans run from -500 mV to -1,500 mV at a scan rate of 100 mV/s), then the electrodes were mechanically polished using polishing pad and alumina slurry (particle size 1 and 0.3 μm, each for 5 min) and left in hot piranha solution for 20 min (H 2 O 2 and H 2 SO 4 at 1+3 ratio, caution: handle with a special care).…”

Section: Electrode Pretreatment Biosensor Preparation and Eis Analysismentioning

confidence: 99%

Glycoprofiling as a novel tool in serological assays of systemic sclerosis: A comparative study with three bioanalytical methods

Kluková

Bertók

Petrikova

et al. 2015

Analytica Chimica Acta

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Systemic sclerosis (SSc) is an autoimmune disease seriously affecting patient´s quality of life. The heterogeneity of the disease also means that identification and subsequent validation of biomarkers of the disease is quite challenging. A fully validated single biomarker for diagnosis, prognosis, disease activity and assessment of response to therapy is not yet available. The main aim of this study was to apply an alternative assay protocol to the immunoassay-based analysis of this disease by employment of sialic acid recognizing lectin Sambucus nigra agglutinin (SNA) to glycoprofile serum samples. To our best knowledge this is the first study describing direct lectin-based glycoprofiling of serum SSc samples. Three different analytical methods for glycoprofiling of serum samples relying on application of lectins are compared here from a bioanalytical point of view including traditional ELISA-like lectin-based method (ELLA), novel fluorescent lectin microarrays and ultrasensitive impedimetric lectin biosensors. Results obtained by all three bioanalytical methods consistently showed differences in the level of sialic acid present on glycoproteins, when serum from healthy people was compared to the one from patients having SSc. Thus, analysis of sialic acid content in human serum could be of a diagnostic value for future detection of SSc, but further work is needed to enhance selectivity of assays for example by glycoprofiling of a fraction of human serum enriched in antibodies for individual diagnostics.

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An optimised electrode pre-treatment for SAM formation on polycrystalline gold

Cited by 90 publications

References 44 publications

An electrochemical biosensor based on DNA tetrahedron/graphene composite film for highly sensitive detection of NADH

An electrochemical biosensor based on DNA tetrahedron/graphene composite film for highly sensitive detection of NADH

Elucidating Capacitance and Resistance Terms in Confined Electroactive Molecular Layers

Glycoprofiling as a novel tool in serological assays of systemic sclerosis: A comparative study with three bioanalytical methods

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