An oral nutraceutical containing antioxidants, minerals and glycosaminoglycans improves skin roughness and fine wrinkles

Abstract

Various nutraceuticals (dietary supplements) are claimed to have cutaneous antiageing properties, however, there are a limited number of research studies supporting these claims. The objective of this research was to study the effectiveness of an oral nutraceutical containing antioxidants, minerals and glycosaminoglycans on cutaneous ageing. In this double-blind, placebo-controlled trial, 60 women aged 35-60 years were randomized to receive oral dietary supplement (n = 30) or placebo (n = 30), once daily for 12 weeks. The depth of skin roughness and fine wrinkles were measured using surface evaluation of skin parameters for living skin (Visioscan) at baseline, and at the 4, 8 and 12 weeks of treatment. Surface evaluation using a replica film (Visiometer) at baseline and at the 12th week of treatment was also carried out. Statistical differences in objective skin improvement were assessed by the independent t-test. The volunteers' satisfaction was tested using the chi-squared test. The baseline depth of skin roughness and fine wrinkles in the treatment group and the placebo group were 100.5 and 100 mum, respectively. At the end of the study, the depth of skin roughness and fine wrinkles in the treatment group showed a 21.2% improvement, whereas improvement in the control group was 1.7%. This difference was statistically significant (P < 0.001). With regard to the volunteers' satisfaction, there was no statistically significant decrease in the homogenization of skin colour, however, a statistically significant reduction in pore size and depth of skin roughness and fine wrinkles were observed (P < 0.05). No side effects were noted throughout the study. The oral dietary supplement containing antioxidants, minerals and glycosaminoglycans improved skin roughness and fine wrinkles but did not affect skin colour change in female volunteers.

Can dietary intake influence perception of and measured appearance? A Systematic Review

“…Thirteen studies had two intervention arms (control/intervention) [25][26][27][29][30][31][32][33][34][35][36][37][38], two had one arm [29] , one had three [39] and one had six intervention arms [28]. The majority of studies (15 out of 17) evaluated the effect of various dietary supplements with several active…”

“…Five of the nine studies that investigated the effect of dietary supplementation found significant improvements in facial wrinkles (periocular [26,27,31,32,38], forehead [27] and perioral [27] areas). These studies investigated various active ingredients and doses, including dietary supplements (n=3), [27,32,38] red ginseng root (n=1) [26] and squalene (n=1) [31] and measured facial wrinkles using skin replicas (impressions using silicon) or skin vision meters.…”

“…These studies investigated various active ingredients and doses, including dietary supplements (n=3), [27,32,38] red ginseng root (n=1) [26] and squalene (n=1) [31] and measured facial wrinkles using skin replicas (impressions using silicon) or skin vision meters.…”

“…Of seven studies that examined intakes of various supplements on skin structure and texture, four found significant improvements in skin 'roughness' [33,34,37,38] and three in skin elasticity [30,33,37]. Supplement intake from green tea and dietary supplements (with a variety of active ingredients) improved both skin elasticity and roughness whilst the intake of high flavonol cocoa improved skin roughness only [34].…”

“…Side effects: adverse event swollen tongue from one participant in active treatment group [38] To evaluate the potential benefits of an oral nutraceutical on cutanoues ageing.…”