An organic electronic ion pump to regulate intracellular signaling at high spatiotemporal resolution

Simon, Daniel T.; Jager, Edwin; Tybrandt, Klas; Larsson, Karin C.; Kurup, Sindhulakshmi; Richter‐Dahlfors, Agneta; Berggren, Magnus

doi:10.1109/sensor.2009.5285721

Cited by 11 publications

(9 citation statements)

References 16 publications

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“…For these reasons, organic semiconductors have lately been used for a broad spectrum of bioelectronics applications. For example, to more directly sense and monitor relevant physiological parameters and convert them to electronic signals [12], or conversely, to regulate (actuate) the physiology of cells and tissues with high spatiotemporal resolution [13]. In addition, organic semiconductors have the advantage of mechanical flexibility, the softness required for biotic interfaces, and ease of processing.…”

Section: Organic Bioelectronics and Iontronicsmentioning

confidence: 99%

“…Iontronic devices have mainly two components, electrodes and IEM, of which the IEM can be considered as the heart of these devices [31]. Several IEMs have been successfully used in various iontronic components and there has been tremendous growth in the field of IEMs for iontonic devices from linear IEM materials that show excellent conducting properties for smaller ions like Na + , K + , Ca 2+ , Cl -, and Iand biomoelecules less than 200 g/mol like GABA + , acetylcholine (Ach + ), and salicylic acid (SA -), to tailor-made IEM materials such as hyperbranched polyglycerol that has shown excellent proven transport properties for larger ions like indigo carmine (466 g/mol) and methylene blue (320 g/mol) [13,[32][33][34][35]. The most widely used ion transport membrane for the first generation OEIPS was over-oxidized PE-DOT:PSS acting as a CEM (see section 5.1.3.1).…”

Section: Towards Iontronic Devicesmentioning

confidence: 99%

“…In OEIPs these polyelectrolytes are patterned onto any substrates and encapsulated. There will be source and target reservoirs as shown in Figure 2.1 and two electrodes for source and target [13]. The polyelectrolyte connecting the source and channel electrolyte is composed of a polyanion (considering Figure 2.1 a as an example), where the negative fixed charges on the polymer are electrostatically compensated by mobile cations.…”

Section: Iontronic Resistor or Organic Electronic Ion Pump (Oeip)mentioning

confidence: 99%

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Expanding the versatility and functionality of iontronic devices

Cherian

2021

Linköping Studies in Science and Technology. Dissertations

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Biological systems rarely use electrons as signal regulators, most of the transport and communication in these system utilize ions. The discovery of conjugated polymers and polyelectrolytes and their unique properties of mixed ionic electronic properties opened the possibility of using these in the domain of bioelectronics, which paved the way for the field of organic bioelectronics. After the introduction of the organic electronic ion pump (OEIP) in 2007, which utilizes both the ionic properties of conjugated polymers and polyelectrolytes, the new field of "iontronics" evolved. The OEIP is an organic polymer-based delivery system based on electrophoretic transport of biologically relevant and ionically charged species, without fluid flow and with high spatial, temporal, and dosage precision. These devices have been extensively studied for the past 14 years and have found numerous demonstrations in in vivo and in vitro delivery of bio-relevant ions for therapeutic application. This has, in parallel, resulted in the development of custom materials for ion exchange membranes (IEMs) within the OEIP.

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Section: Organic Bioelectronics and Iontronicsmentioning

confidence: 99%

Section: Towards Iontronic Devicesmentioning

confidence: 99%

Section: Iontronic Resistor or Organic Electronic Ion Pump (Oeip)mentioning

confidence: 99%

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Expanding the versatility and functionality of iontronic devices

Cherian

2021

Linköping Studies in Science and Technology. Dissertations

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“…One of the tools that could be used for organ specific delivery of effective compounds to plants are organic electronic ion pumps (OEIPs), a polymer-based delivery system and organic electrochemical transistor (OECT) (Simon et al, 2009a ; Nielsen et al, 2016 ). They can deliver with high precision and efficiency a range of biologically relevant substances.…”

Section: Sensing Devices—on the Way To Biohybridmentioning

confidence: 99%

“…They can deliver with high precision and efficiency a range of biologically relevant substances. Ion transport was shown to be able to mimic, and to precisely affect Ca 2+ signaling in a programmed way (Simon et al, 2009a , b ). It was demonstrated that OEIPs can be used as programmable “machine-to-brain” (or “machine-to-cell”) communication platform.…”

Section: Sensing Devices—on the Way To Biohybridmentioning

confidence: 99%

Plant Science View on Biohybrid Development

Skrzypczak

Krela

Kwiatkowski

et al. 2017

Front. Bioeng. Biotechnol.

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Biohybrid consists of a living organism or cell and at least one engineered component. Designing robot–plant biohybrids is a great challenge: it requires interdisciplinary reconsideration of capabilities intimate specific to the biology of plants. Envisioned advances should improve agricultural/horticultural/social practice and could open new directions in utilization of plants by humans. Proper biohybrid cooperation depends upon effective communication. During evolution, plants developed many ways to communicate with each other, with animals, and with microorganisms. The most notable examples are: the use of phytohormones, rapid long-distance signaling, gravity, and light perception. These processes can now be intentionally re-shaped to establish plant–robot communication. In this article, we focus on plants physiological and molecular processes that could be used in bio-hybrids. We show phototropism and biomechanics as promising ways of effective communication, resulting in an alteration in plant architecture, and discuss the specifics of plants anatomy, physiology and development with regards to the bio-hybrids. Moreover, we discuss ways how robots could influence plants growth and development and present aims, ideas, and realized projects of plant–robot biohybrids.

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Electronic and Ionic Materials for Neurointerfaces

Ferro

Melosh

2017

Adv Funct Materials

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Communication between living brain tissue and engineered devices is the key link to understand brain function and restore neurological deficits from disease, injury, and old age. Enabled by new materials and device designs, a new generation of brain interface technologies is replacing bulkier systems, offering lower tissue damage, reduced immunogenicity, and long‐term stability. New electrode materials with improved chronic performance and increasing emphasis on multimodal capabilities are being integrated onto ultraflexible and mechanically compliant architectures. As these scale to smaller dimensions and higher channel counts, the goal of bidirectional, single‐cell interfaces is nearly within reach. However, promising, long‐term reliability, toxicity, and performance of these systems are still largely unknown. Here, the basics of electrode materials and in vivo technologies are reviewed, and recent advances in electronic and ionic materials are highlighted.

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An organic electronic ion pump to regulate intracellular signaling at high spatiotemporal resolution

Cited by 11 publications

References 16 publications

Expanding the versatility and functionality of iontronic devices

Expanding the versatility and functionality of iontronic devices

Plant Science View on Biohybrid Development

Electronic and Ionic Materials for Neurointerfaces

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