An Outbreak of Early-Onset Endophthalmitis Caused by<i>Fusarium</i>Species following Cataract Surgery

Çakir, Mehmet; İmamoğlu, Serhat; Çekıç, Osman; Bozkurt, Ercüment; Alagöz, Neşe; Öksüz, Lütfiye; Yılmaz, Ömer Faruk

doi:10.3109/02713680903254822

Cited by 48 publications

(38 citation statements)

References 24 publications

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“…36,37 It is notable that one of the outbreaks caused by Fusarium was associated with contamination during reconstitution of cefuroxime used for intracameral endophthalmitis prophylaxis at the end of cataract surgery. 7 Eight patients were infected with Fusarium, and only 3 attained a final visual acuity of 20/400 or better.…”

Section: Discussionmentioning

confidence: 99%

“…Potential sources of these outbreaks include bacterial contamination from the surgical intraocular instruments, irrigating fluids, or the surgical environment. [4][5][6][7][8][9] To gain a better perspective of the outbreaks, we performed a review of the literature to report the causative organisms, the possible etiological sources, and the visual acuity outcomes.…”

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confidence: 99%

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Endophthalmitis outbreaks following cataract surgery: Causative organisms, etiologies, and visual acuity outcomes

Pathengay

Flynn

Isom

et al. 2012

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Endophthalmitis outbreaks following cataract surgery: Causative organisms, etiologies, and visual acuity outcomes

Pathengay

Flynn

Isom

et al. 2012

Journal of Cataract and Refractive Surgery

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“…Si bien se han descrito brotes de infecciones por hongos asociados a la contaminación intrínseca de fármacos, como el ocasionado por contaminación de inyecciones de metilprednisolona en E.U.A. el año 2012 16,17 el rol de los hongos en este tipo de brotes es ocasional, asociándose a endoftalmitis [17][18][19] e infecciones intestinales 20 .…”

Section: Discussionunclassified

Brote de fungemias por Sarocladium kiliense en ocho hospitales públicos por contaminación intrínseca de ondansetrón intravenoso

Orsini

Otaíza

Vega

et al. 2018

Rev. chil. infectol.

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Outbreak of fungemias by Sarocladium kiliense in eight public hospitals per intrinsic contamination of ondansetron intravenous Sarocladium kiliense is a saprophyte fungus that can cause opportunistic infections associated to invasive procedures. We report a multi-hospital nosocomial outbreak of fungemias due to this agent. Patients with positive blood culture to this agent were studied after six bloodstream infections identified in three Chilean hospitals in July 2013 were reported to Ministry of Health National Infection and Prevention Control Program. In general, there were mild clinical manifestations, without deaths attributable to the infection. Epidemiological and microbiological study identified 65 cases in 8 hospitals, mostly pediatric patients in chemotherapy. Initial studies of 94 different drugs and medical devices had negative results, until a second analysis of specific blisters and their pharmaceutical matrix selected by epidemiological criteria identified an intrinsic contamination of ondansetron blisters from a specific producer used in all the patients. A recall of contaminated ondansetron blisters was performed in all the country, after which the outbreak was contained. Surveillance and response of local and national infection prevention and control programs and laboratory support were key to control of a national multi-hospital common source outbreak due to contamination of a drug by an unusual fungus.

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“…38 Only two of nine eyes (with corneal involvement) were lost in the endophthalmitis outbreak in our hospital. 39 The disease was controlled with aggressive medical and surgical therapy in patients with corneal involvement, but corneal opacification and final poor vision could not be prevented.…”

Section: Discussionmentioning

confidence: 99%

An outbreak of Fusarium solani endophthalmitis after cataract surgery in an eye training and research hospital in Istanbul

Güngel

Eren

Pınarcı

et al. 2011

Mycoses

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To report an outbreak of Fusarium solani endophthalmitis after uneventful cataract surgeries performed on the same day in the same operating room. Nine patients underwent phacoemulsification at 4th Clinic of Beyoglu Eye Training and Research Hospital in Istanbul. Cefuroxime axetyl was injected intracamerally from the same vial to all patients at the end of surgery. All patients developed acute postoperative endophthalmitis. Presentation, cultural studies, treatment, clinical responses and risk factors were evaluated. Cultural and DNA sequence findings revealed F. solani. Antifungal therapy was begun and pars plana vitrectomy, intraocular lens and capsule extraction were performed. Corneal involvement was correlated with old age and systemic disease. Fusarium solani should be considered in acute postoperative endophthalmitis. This infection can be controlled with early and aggressive combined antifungal and surgical treatment. The patients with corneal involvement had poor prognosis. It is important to use solutions prepared separately for each patient.

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An Outbreak of Early-Onset Endophthalmitis Caused byFusariumSpecies following Cataract Surgery

Cited by 48 publications

References 24 publications

Endophthalmitis outbreaks following cataract surgery: Causative organisms, etiologies, and visual acuity outcomes

Endophthalmitis outbreaks following cataract surgery: Causative organisms, etiologies, and visual acuity outcomes

Brote de fungemias por Sarocladium kiliense en ocho hospitales públicos por contaminación intrínseca de ondansetrón intravenoso

An outbreak of Fusarium solani endophthalmitis after cataract surgery in an eye training and research hospital in Istanbul

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