An outbreak of Serratia marcescens septicaemia in neonatal intensive care unit in Gaza City, Palestine

Jarousha, Abdel Moati Kh. Al; Qouqa, Iyad A. El; Jadba, A.H.N. El; Afifi, Ahmed S. Al

doi:10.1016/j.jhin.2008.06.028

Cited by 34 publications

(36 citation statements)

References 20 publications

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“…Outbreaks of sepsis/bacteremia (4,18,74,88,116,157,215,238,258,310,341,359,362,423), meningitis (74,88,116,157,362,423), conjunctivitis (74,88,116), UTIs (116), respiratory tract infections (74,88,116,285,359), and wound infections (362) due to S. marcescens have all been described for pediatric patients since the series of infections described by McCormack and Kunin in 1966 (259). Conjunctivitis appears to be more common in pediatric population outbreaks in hospitals than in adult populations.…”

Section: S Marcescensmentioning

confidence: 99%

Serratia Infections: from Military Experiments to Current Practice

2011

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SUMMARY Serratia species, in particular Serratia marcescens , are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history. The organisms in this genus, particularly S. marcescens , were long thought to be nonpathogenic. Because S. marcescens was thought to be a nonpathogen and is usually red pigmented, the U.S. military conducted experiments that attempted to ascertain the spread of this organism released over large areas. In the process, members of both the public and the military were exposed to S. marcescens , and this was uncovered by the press in the 1970s, leading to U.S. congressional hearings. S. marcescens was found to be a certain human pathogen by the mid-1960s. S. marcescens and S. liquefaciens have been isolated as causative agents of numerous outbreaks and opportunistic infections, and the association of these organisms with point sources such as medical devices and various solutions given to hospitalized patients is striking. Serratia species appear to be common environmental organisms, and this helps to explain the large number of nosocomial infections due to these bacteria. Since many nosocomial infections are caused by multiply antibiotic-resistant strains of S. marcescens , this increases the danger to hospitalized patients, and hospital personnel should be vigilant in preventing nosocomial outbreaks due to this organism. S. marcescens , and probably other species in the genus, carries several antibiotic resistance determinants and is also capable of acquiring resistance genes. S. marcescens and S. liquefaciens are usually identified well in the clinical laboratory, but the other species are rare enough that laboratory technologists may not recognize them. 16S rRNA gene sequencing may enable better identification of some of the less common Serratia species.

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Section: S Marcescensmentioning

confidence: 99%

Serratia Infections: from Military Experiments to Current Practice

2011

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“…This sensitivity may be related to the thin cell walls and susceptibility of these bacteria to acidic metabolites. S. marcescens is involved in different hospital-acquired infections, such as wound and urinary tract infections; hospital outbreaks caused by S. marcescens antibiotic-resistant strains have also been reported (Al Jarousha et al, 2008). Klebsiella pneumonia causes different diseases, such as pneumonia and urinary tract infections, particularly among the elderly with weakened immune system; K. pneumoniae strains also show high rates of resistance to antibiotics (Hussein et al, 2013;Shoma et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Potentially probiotic acetic acid bacteria isolation and identification from traditional dairies microbiota

Haghshenas

Nami

Abdullah

et al. 2014

Int J of Food Sci Tech

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Summary Among probiotics, acetic acid bacteria (AAB) can be used as preservative agents because of their high fermentation and acidification activities. This study aimed to isolate, identify and biologically characterise Acetobacter strains from traditional Iranian dairy products. Acetobacter strains were identified by catalase assay, Gram staining, and combined repetitive sequence‐based PCR [(GTG)5‐PCR fingerprints] and 16S rDNA gene sequencing. We identified eight strains belonging to four species, including Acetobacter aceti, Acetobacter indonesiensis, Acetobacter cibinongensis and Acetobacter syzygii. The molecular techniques could be used as an effective and rapid alternative tool to identify and characterise dairy‐associated AAB. Primary probiotic assessments, including low pH and high bile salt tolerance tests, antagonistic activity test against pathogens, and antibiotic susceptibility confirmed the probiotic properties of these AAB, particularly A. cibinongensis 34L strain, which was isolated from curd. Therefore, this strain can be introduced as novel candidate probiotics that could be used in the food industry.

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“…Significant risk factors for S. marcescens infections in neonates are a very low birthweight of <1500 g, being born premature at <37 weeks of gestation and receiving mechanical ventilation . A prolonged NICU stay leads to limited maternal contact and exposure to NICU flora and antibiotics and that is why the bacterial colonisation pattern of NICU neonates differs from that of healthy neonates .…”

Section: Introductionmentioning

confidence: 99%

“…Several outbreaks of S. marcescens in NICUs have been reported, with the duration ranging from several months to years (). This study describes an outbreak in a Finnish NICU, which was rapidly managed with hospital hygienic interventions and education.…”

Section: Introductionmentioning

confidence: 99%