A <i>Serratia marcescens</i> outbreak in a neonatal intensive care unit was successfully managed by rapid hospital hygiene interventions and screening

Åttman, Emilia; Korhonen, Päivi; Tammela, Outi; Vuento, Risto; Aittoniemi, Janne; Syrjänen, Jaana; Mattila, Erja; Österblad, Monica; Huttunen, Reetta

doi:10.1111/apa.14132

Cited by 22 publications

(11 citation statements)

References 20 publications

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“…In conclusion, all laboratory-run typing methods, wgMLST included, are valuable in the context of hospital-wide screening for pathogens but also for analyses of random clinical isolates (27,28). wgMLST for S. marcescens has here been demonstrated to be a promising epidemiological typing support tool.…”

Section: Resultsmentioning

confidence: 91%

Epidemiological Typing of Serratia marcescens Isolates by Whole-Genome Multilocus Sequence Typing

et al. 2019

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Serratia marcescens is an opportunistic bacterial pathogen. It is notorious for its increasing antimicrobial resistance and its potential to cause outbreaks of colonization and infections, predominantly in neonatal intensive care units (NICUs). There, its spread requires rapid infection control response. To understand its spread, detailed molecular typing is key. We present a whole-genome multilocus sequence typing (wgMLST) method for S. marcescens. Using a set of 299 publicly available whole-genome sequences (WGS), we developed an initial wgMLST system consisting of 9,377 gene loci. This included 1,455 loci occurring in all reference genomes and 7,922 accessory loci. This closed system was validated using three geographically diverse collections of S. marcescens consisting of 111 clinical isolates implicated in nosocomial dissemination events in three hospitals. The validation procedure showed a full match between epidemiological data and the wgMLST analyses. We set the cutoff value for epidemiological (non)relatedness at 20 different alleles, though for the majority of outbreak-clustered isolates, this difference was limited to 4 alleles. This shows that the wgMLST system for S. marcescens provides prospects for successful future monitoring for the epidemiological containment of this opportunistic pathogen.

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Section: Resultsmentioning

confidence: 91%

Epidemiological Typing of Serratia marcescens Isolates by Whole-Genome Multilocus Sequence Typing

et al. 2019

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“…Nowadays, S. marcescens is unquestionably regarded as an etiological agent of opportunistic infections in humans, particularly in neonates and small children, but also in severely immunocompromised adults. [2][3][4][5] Samonis et al showed that more than 88% of Serratia spp. strains isolated from patients in Cretan hospitals between 2010 and 2015 were identified as S. marcescens.…”

Section: Discussionmentioning

confidence: 99%

“…At present, 30 species of Serratia are recognized, out of which S. marcescens is the species most important in medicine, causing a wide range of diseases, particularly in neonates and small children as well as in hospitalized and/or immunocompromised adult patients. [2][3][4][5][6] Serratia marcescens affects, most often, the urinary tract, skin and soft tissue, the central nervous system (CNS), the eye, or leads to pneumonia or sepsis. 2,7,8 Antimicrobial resistance of S. marcescens is mediated by the resistance genes located on the bacterial chromosome and on the mobile genetic elements, eg, plasmids and integrons.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Class 1, 2 and 3 Integrons in Serratia spp. Clinical Isolates in Poland – Isolation of a New Plasmid and Identification of a Gene for a Novel Fusion Protein

Celejewski-Marciniak

Wolinowska

Wróblewska

2021

IDR

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“…Many outbreaks are frequently reported worldwide especially in neonatal intensive care units, where the bacteria usually spread rapidly and is associated with significant morbidity and mortality. The sources of the outbreaks have been associated to contaminated laryngoscope blades, hands, ventilator equipment, disinfectants, and breast pumps (Gransden et al, 1986 ; Jones et al, 2000 ; Sartor et al, 2000 ; Jang et al, 2001 ; Villari et al, 2001 ; Fleisch et al, 2002 ; Uduman et al, 2002 ; Cullen et al, 2005 ; Montagnani et al, 2015 ; Åttman et al, 2018 ).…”

Section: Microorganisms Transmitted Through Triatomine/man Contact Anmentioning

confidence: 99%

Triatomines: Trypanosomatids, Bacteria, and Viruses Potential Vectors?

Vieira

Praça

Bentes

et al. 2018

Front. Cell. Infect. Microbiol.

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Triatominae bugs are the vectors of Chagas disease, a major concern to public health especially in Latin America, where vector-borne Chagas disease has undergone resurgence due mainly to diminished triatomine control in many endemic municipalities. Although the majority of Triatominae species occurs in the Americas, species belonging to the genus Linshcosteus occur in India, and species belonging to the Triatoma rubrofasciata complex have been also identified in Africa, the Middle East, South-East Asia, and in the Western Pacific. Not all of Triatominae species have been found to be infected with Trypanosoma cruzi, but the possibility of establishing vector transmission to areas where Chagas disease was previously non-endemic has increased with global population mobility. Additionally, the worldwide distribution of triatomines is concerning, as they are able to enter in contact and harbor other pathogens, leading us to wonder if they would have competence and capacity to transmit them to humans during the bite or after successful blood feeding, spreading other infectious diseases. In this review, we searched the literature for infectious agents transmitted to humans by Triatominae. There are reports suggesting that triatomines may be competent vectors for pathogens such as Serratia marcescens, Bartonella, and Mycobacterium leprae, and that triatomine infection with other microrganisms may interfere with triatomine-T. cruzi interactions, altering their competence and possibly their capacity to transmit Chagas disease.

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A Serratia marcescens outbreak in a neonatal intensive care unit was successfully managed by rapid hospital hygiene interventions and screening

Abstract: A S. marcescens outbreak caused significant morbidity in neonates and one death. Rapid hospital hygiene interventions and patient screening effectively contained the outbreak.

Cited by 22 publications

References 20 publications

Epidemiological Typing of Serratia marcescens Isolates by Whole-Genome Multilocus Sequence Typing

Epidemiological Typing of Serratia marcescens Isolates by Whole-Genome Multilocus Sequence Typing

Molecular Characterization of Class 1, 2 and 3 Integrons in Serratia spp. Clinical Isolates in Poland – Isolation of a New Plasmid and Identification of a Gene for a Novel Fusion Protein

Triatomines: Trypanosomatids, Bacteria, and Viruses Potential Vectors?

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