An Outlook for a Novel Approach: Self-Micro Emulsifying Drug Delivery System (SMEDDS)

Barakoti, Himal; Choudhury, Ananta; Dey, Biplab Kumar

doi:10.5958/0974-360x.2019.00340.8

Cited by 5 publications

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“… Along with lipids, surfactants commonly used in SMEDDS formulations, such as Tween 80, Spans, Cremophors (EL and RH40), and Pluronic's, are reported to have an inhibitory effect on efflux transporters that help in improving the bioavailability of the drugs 30,32,33,34 . The surfactant Tocopheryl polyethylene glycol succinate 1000 (TPGS), which is produced by esterifying vitamin E succinate and polyethylene glycol 1000, has an inhibitory effect on efflux transporters such as Pglycoprotein 42 .…”

Section: Advantagesmentioning

confidence: 99%

“…Incorporating liquid SMEDDS into a solid dosage form provides the benefit of SMEDDS with those of solid formulations and overcomes the drawbacks associated with this system. With this aim, an experimental design strategy to optimize a SMEDDS formulation of the tablet can be adopted, and the simplest composition in terms of drug dissolution properties can be selected 33 .…”

Section: Introductionmentioning

confidence: 99%

“…The opening of tight junctions by surfactants helps in improved permeability, as shown in the study by Sha et al a greater permeability of the drug with the Labrasol surfactant was observed due to the opening of tight junctions 60 . The inhibitory effect of surfactants on the p-glycoprotein helps to improve the overall bioavailability of many drug substrates for the p-glycoprotein transporter 33 . Although natural surfactants are less toxic, the effectiveness of self-emulsification is limited 36 .…”

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confidence: 99%

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2022

IJPSR

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SMEDDS are formulated to improve the oral bioavailability of lipophilic drugs. It is an isotropic mixture of compounds like oil, surfactant, co-surfactant, and drug having the unique ability to form fine o/w micro-emulsion by agitation and diluted with GI fluid. Its liquid formulation technique enhanced the absorption and bioavailability of poorly watersoluble drugs but also had a few drawbacks like long time period stability issues and storage conditions. Some special techniques convert the liquid form into solid dosage form to overcome these problems. The present paper gives exhaustive information about formulation design by screening excipients. We study the selection and solubility of excipients, its preparation and characterization, and the mechanism by which bioavailability can be improved. This discussion is useful for a better understanding of SMEDDS for its recent advancements, marketed formulation, and patents on SMEDDS. The poorly water-soluble drugs having dissolution rate absorption limited can be effectively formulated in the form of SMEDDS causing a stable plasma profile. The plasma levels of the poorly aqueous soluble medicament show the critical passage of drug absorption, i.e., dissolution. Surfactants with a high HLB value, such as Tween 80 are said to increase the permeability of active ingredients when administered in conjunction with the formulation due to their loosening effect on tight junctions.

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Section: Advantagesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2022

IJPSR

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“…Change in droplet size over the period of 24 hours, 7 days and 28 days were analyzed to determine kinetic stability of the microemulsion 6,7 . The microemulsion were centrifuged at 3000 RPM (Eppendorf Centrifuge 5430 R) for half an hour.…”

Section: Emulsion Stability Testmentioning

confidence: 99%

Preparation and Evaluation of Microemulsion Containing Clove Oil and Peppermint Oil as Active Compound

Changmai¹,

Adhikari²,

Dey³

2019

J. Pharm. Sci. Innov.

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Microemulsion are one of the potential and emerging drug carrier systems that helps to improve drug release and enhance the bioavailability of poorly aqueous soluble drugs. This study was designed to formulate and evaluate microemulsion containing clove oil and peppermint oil. Microemulsion was prepared using tween 80 as a surfactant and ethanol as a co-surfactant. The microemulsion formulation characterized for its particle size, viscosity, conductivity, pH, zeta potential and stability. The mean droplet size of clove oil and peppermint oil microemulsion was found in the range of 11-96nm and 11-68nm. The viscosity of the prepared microemulsions were found to be low. In the stability study there are no phase separation occur after centrifuged at 3000 RPM for 30 min and even after stored for 30 days.

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“…It has subsequent advantages of ease of administration thus generating better patient compliance. [1,2] The therapeutic effectiveness depends on factors as gastric emptying time, gastric pH, drug release from the dosage form, extent of absorption, etc. The approach of drug delivery also plays an important role in the drug-releasing capability in the systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

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2020

IJPBA

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Floating drug delivery approach uses low-density systems that have sufficient buoyancy to flow over the gastric contents and remains buoyant in the stomach without affecting the stomachic emptying rate for a chronic period of time. This result is increased gastric retention time and better control of the fluctuations in plasma drug concentration with a low risk of toxicity. Drugs, which are locally active in the stomach, drugs having narrow absorption window and unstable in the intestine, and colonic environment, are the potential drug candidates. The approach not only improves drug absorption but also minimizes the mucosal irritation of drugs. As the approach requires a high fluid level in the stomach to float and work efficiently, it makes the approach limited up to some extent. Many buoyant systems have been developed based on granules, powders, capsules, tablets, laminated films, and hollow microspheres and few formulations have been commercialized in the market at the present time. This review gives an overview of the approach of floating drug delivery at present with sequential demystification thus enabling a greater understanding of their role in medicine and drug delivery.

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An Outlook for a Novel Approach: Self-Micro Emulsifying Drug Delivery System (SMEDDS)

Cited by 5 publications

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Preparation and Evaluation of Microemulsion Containing Clove Oil and Peppermint Oil as Active Compound

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