An overall assessment of the effects of antidepressant paroxetine on aquatic organisms and human cells

Αντωνοπούλου, Μαρία; Dormousoglou, Margarita; Spyrou, Alexandra; Dimitroulia, Alexandra; Vlastos, Dimitris

doi:10.1016/j.scitotenv.2022.158393

Cited by 12 publications

(3 citation statements)

References 77 publications

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“…So, psychotropic drugs are becoming more widely used, and PRX is one of the most commonly used antidepressants. 72 Sequentially, the health issues caused by the high consumption of PRX (e.g., drug abuse and drug contamination) have aroused people's concern. 73 As a consequence, there is an urgent need to develop a rapid and sensitive analytical technique for the detection of PRX.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…With the modern social life getting more and more stressful, the incidence of insomnia, depression, and other mental diseases increases year by year. So, psychotropic drugs are becoming more widely used, and PRX is one of the most commonly used antidepressants . Sequentially, the health issues caused by the high consumption of PRX (e.g., drug abuse and drug contamination) have aroused people’s concern .…”

Section: Resultsmentioning

confidence: 99%

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An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

Sun,

Xie,

Tang

et al. 2024

Inorg. Chem.

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Advances in polyoxometalate (POM) self-assembly chemistry are always accompanied by new developments in molecular blocks. The exploration and discovery of uncommon building blocks offer great possibilities for generating unprecedented POM clusters. An intriguing SbIII–WVI-cotemplated antimonotungstate [H2N(CH3)2]11Na[SbW9O33]Er2(H2O)2Sb2[SbWVIW15O57]·22H2O (1) was synthesized, which comprises a classical trivacant Keggin [SbW9O33]9– ({SbW9}) fragment and an unclassical lacunary Dawson-like [SbWVIW15O57]15– ({SbWVIW15}) subunit. Notably, the Dawson-like {SbWVIW15} subunit is the first example of a [SbO3]3– and [WVIO6]6– mixed-heteroatom-directing POM segment. Hexacoordinated [WVIO6]6– can not only serve as the heteroatom function but its additional oxygen sites can also link to lanthanide, main-group metal, and transition-metal centers to form the innovative structure. {SbWVIW15} and {SbW9} subunits are joined by the heterometallic [Er2(H2O)2Sb2O17]22– cluster to give rise to an asymmetric sandwich-type architecture. To further realize its potential application in electrochemical sensing, a conductive 1@rGO composite was obtained by the electrochemical deposition of 1 with graphene oxide (GO). Using a 1@rGO-modified glassy carbon electrode as the working electrode, an electrochemical biosensor for detecting the antidepressant drug paroxetine (PRX) was successfully constructed. This work can provide a viable strategy for synthesizing mixed-heteroatom-directing POMs and demonstrates the application of POM-based materials for the electrochemical detection of drug molecules.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

Sun,

Xie,

Tang

et al. 2024

Inorg. Chem.

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“…Algae are the base of the aquatic food chain, and potential detrimental effects to them can significantly affect the higher trophic levels [48]. Among the freshwater microalgae, Scenedesmus rubescens has been widely used in ecotoxicology studies [49,50]. The evolution of toxicity during the photocatalytic process against freshwater microalgae Scenedesmus rubescens was evaluated in UPW and LW (Figure 5a,b).…”

Section: Photocatalytic Detoxification Performancementioning

confidence: 99%

Heterogeneous Photocatalytic Oxidation and Detoxification of Simulated Agricultural Wastewater Contaminated with Boscalid Fungicide Using g-C3N4 Catalyst

Antonopoulou,

Tzamaria,

Miserli

et al. 2024

Catalysts

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In the present study, the photocatalytic oxidation and detoxification of aqueous matrices contaminated with boscalid using g-C3N4 catalyst and UV-A light was investigated. The UV-A/g-C3N4 process was found to achieve higher than 83% removal of boscalid in both matrices, with h+ and O2•− being the main species. UHPLC-HRMS analysis allowed the identification of five TPs, while the main degradation pathways involved hydroxylation, cyclization, and dechlorination. Scenedesmus rubescens microalgae species was exposed to boscalid solutions and lake water spiked with the fungicide before the photocatalytic treatment and inhibition in the growth rate was observed. An increase in the toxicity was also observed during the first stages of the treatment. The results from the in silico study correlate with the observed evolution of ecotoxicity during the application of the process, as some of the identified TPs were found to be toxic or very toxic for aquatic organisms. However, prolonged application of the process can lead to detoxification. It was also observed that the g-C3N4 catalyst can retain its photochemical stability and activity after at least three cycles. However, a slight decrease in the activity was observed when repeated another two times. This study demonstrated that the suggested photocatalytic process can both decrease the harmful effects of boscalid as well as effectively lower its concentration in water.

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Paroxetine induced larva zebrafish cardiotoxicity through inflammation response

Zhu

Song

et al. 2023

Ecotoxicology and Environmental Safety

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An overall assessment of the effects of antidepressant paroxetine on aquatic organisms and human cells

Cited by 12 publications

References 77 publications

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

Heterogeneous Photocatalytic Oxidation and Detoxification of Simulated Agricultural Wastewater Contaminated with Boscalid Fungicide Using g-C3N4 Catalyst

Paroxetine induced larva zebrafish cardiotoxicity through inflammation response

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An overall assessment of the effects of antidepressant paroxetine on aquatic organisms and human cells

Cited by 12 publications

References 77 publications

An Innovative SbIII–WVI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

An Innovative SbIII–WVI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

Heterogeneous Photocatalytic Oxidation and Detoxification of Simulated Agricultural Wastewater Contaminated with Boscalid Fungicide Using g-C3N4 Catalyst

Paroxetine induced larva zebrafish cardiotoxicity through inflammation response

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Resources

About

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically