An overview application of silver nanoparticles in inhibition of herpes simplex virus

Akbarzadeh, Abolfazl; Kafshdooz, Leila; Razban, Zohre; Tbrizi, Ali Dastranj; Rasoulpour, Shadi; Khalilov, Rovshan; Kavetskyy, Taras; Saghfi, Siamak; Nasibova, Aygun; Kaamyabi, Sharif; Kafshdooz, Taiebeh

doi:10.1080/21691401.2017.1307208

Cited by 53 publications

(38 citation statements)

References 49 publications

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“…[64,65] These antiviral mechanisms are mainly caused by stress in infected cells (due to physical contact), generation of reactive oxygen species (ROS), interactions with DNA and enzymatic damage. [66] The first mechanism is through the binding of Ag NPs with sulfur residues from the virus's surface glycoproteins, preventing interaction with the receptor and its entry into the host cell. [67,68] The second mechanism involves the passage of Ag NPs through the cell membrane that consequently, it ends up effectively blocking the transcription factors necessary for the adequate assembly of the viral progeny.…”

Section: Resultsmentioning

confidence: 99%

Ag nanoparticles-based antimicrobial polycotton fabrics to prevent the transmission and spread of SARS-CoV-2

Tremiliosi

Simões

Minozzi

et al. 2020

Preprint

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Pathogens (bacteria, fungus and virus) are becoming a potential threat to the health of human beings and environment worldwide. They widely exist in the environment, with characteristics of variety, spreading quickly and easily causing adverse reactions. In this work, an Ag-based material is used to be incorporated and functionalized in polycotton fabrics using pad-dry-cure method. This composite proved to be effective for inhibiting the SARS-CoV-2 virus, decreasing the number of replicates in 99.99% after an incubation period of 2 minutes. In addition, it caused 99.99% inhibition of the pathogens S. aureus, E. coli and C. albicans, preventing cross-infections and does not cause allergies or photoirritation processes, demonstrating the safety of its use.

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Section: Resultsmentioning

confidence: 99%

Ag nanoparticles-based antimicrobial polycotton fabrics to prevent the transmission and spread of SARS-CoV-2

Tremiliosi

Simões

Minozzi

et al. 2020

Preprint

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“…MiRNAs are generally involved in post-transcriptional gene regulation. They are highly conserved among a wide range of species [26]. MiRNAs are key regulators of cellular pathways, and they appear to play an important role in tumourigenesis [27].…”

Section: Mirna and Cancermentioning

confidence: 99%

The role of microRNAs and nanoparticles in ovarian cancer: a review

Kafshdooz

Pourfathi

Akbarzadeh

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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MicroRNAs (miRNAs) have had a revolutionary impact on cancer research over the recent years. They emerge as important players in tumourigenesis, leading to a paradigm shift in oncology. Ovarian cancer is the leading cause of death among gynaecologic malignancies. Therefore, there is a strong need for prognostic and predictive markers for early diagnosis which helps optimize and personalize treatment. Asymptomatically, ovarian cancer is often diagnosed at advanced and incurable stages. Efficient targeting and sustained release of miRNAs/anti-miRNAs using nanoparticles conjugated with antibodies and/or peptides could reduce the required therapeutic dosage while minimizing systemic and cellular toxicity. Given miRNAs importance in clinical oncology, here we focus on the development of miRNA nanoformulations to achieve enhanced cellular uptake, bioavailability and accumulation at the tumour site. Although many obstacles need to be overcome, miRNA therapy could be a powerful tool for ovarian cancer prevention and treatment. In this review, we discuss about the emerging roles of miRNAs in various aspects of ovarian cancer.

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“…For instance, AgNPs have been reported as biomedical therapeutic agents, such as wound dressings and long-term burn care products [57], and anti-bacterial lotions containing silver nanoparticles are now commercially available. However, silver nanoparticle-based antiviral agents are still in the infancy stage, and very few reports have been published about their viricidal activity [58,59]. The latest reports have shown that silver nanoparticles exhibit antiviral activities against influenza A virus, hepatitis B virus, human parainfluenza virus, herpes simplex virus, and human immunodeficiency virus [60].…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

Chen

Liang

2020

Materials Science and Engineering: C

207

163

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Research on highly effective antiviral drugs is essential for preventing the spread of infections and reducing losses. Recently, many functional nanoparticles have been shown to possess remarkable antiviral ability, such as quantum dots, gold and silver nanoparticles, nanoclusters, carbon dots, graphene oxide, silicon materials, polymers and dendrimers. Despite their difference in antiviral mechanism and inhibition efficacy, these functional nanoparticles-based structures have unique features as potential antiviral candidates. In this topical review, we highlight the antiviral efficacy and mechanism of these nanoparticles. Specifically, we introduce various methods for analyzing the viricidal activity of functional nanoparticles and the latest advances in antiviral functional nanoparticles. Furthermore, we systematically describe the advantages and disadvantages of these functional nanoparticles in viricidal applications. Finally, we discuss the challenges and prospects of antiviral nanostructures. This topic review covers 132 papers and will enrich our knowledge about the antiviral efficacy and mechanism of various functional nanoparticles.

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An overview application of silver nanoparticles in inhibition of herpes simplex virus

Cited by 53 publications

References 49 publications

Ag nanoparticles-based antimicrobial polycotton fabrics to prevent the transmission and spread of SARS-CoV-2

Ag nanoparticles-based antimicrobial polycotton fabrics to prevent the transmission and spread of SARS-CoV-2

The role of microRNAs and nanoparticles in ovarian cancer: a review

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

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