An overview of antifungal peptides derived from insect

Faruck, Mohammad Omer; Yusof, Faridah; Chowdhury, Silvia

doi:10.1016/j.peptides.2015.06.001

Cited by 76 publications

(46 citation statements)

References 107 publications

(103 reference statements)

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“…However, these peptides are not considered in detail in this review, due to generally less convenient extraction processes, a limited “natural” aspect for consumers, and potential toxicity. For a more complete description of these peptides, the reader is referred to previous reviews (Faruck, Yusof, & Chowdhury, ; Jenssen et al., ; Lohner & Leber, ; Matejuk et al., ; Van Der Weerden & Anderson, ).…”

Section: Other Sources Of Afpsmentioning

confidence: 99%

Natural Antifungal Peptides/Proteins as Model for Novel Food Preservatives

Thery

Lynch

Arendt

2019

Comp Rev Food Sci Food Safe

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A large range of ingredients for food and food products are subject to fungal contamination, which is a major cause of destruction of crops, exposure of animals and humans to invasive mycotoxins, and food spoilage. The resistance of fungal species to common preservation methods highlights the necessity of new ways to increase the shelf life of raw material for food and food products. Antimicrobial peptides and proteins (AMPs) are essential members of the immune system of most living organisms. Due to their broad range of activity and their stability to commonly used food processes, they represent promising alternatives to traditional preservatives. However, despite the growing number of reports of potential food applications of these AMPs, the number of approved peptides is low. Poor solubility, toxicity, and a time‐consuming extraction are hurdles that limit their application in food products. Thanks to a deep understanding of the key determinants of their activity, the development of optimized synthetic peptides has reduced these drawbacks. This review presents natural and synthetic antifungal peptides/proteins (AFPs), effective against food‐related fungi, with particular emphasis on AFPs from plant sources. The design of novel antifungal peptides via key elements of antifungal activity is also reviewed. The potential applications of natural and synthetic AFPs as novel antifungal food preservatives are finally discussed.

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Section: Other Sources Of Afpsmentioning

confidence: 99%

Natural Antifungal Peptides/Proteins as Model for Novel Food Preservatives

Thery

Lynch

Arendt

2019

Comp Rev Food Sci Food Safe

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“…Biologically active peptides exhibiting antibacterial, antifungal and antiviral activity are found abundantly in insects. Most insects have high anti-microbial peptide (AMP) activity against Gram-positive bacteria but less against Gram-negative bacteria, fungi and yeasts (Faruck et al 2016). Anti-microbial peptides (AMP) are expressed in the fat body and secreted into the haemolymph in response to infection.…”

Section: Epf Culture Filtrate Alters the Abundance Of Amp In The Insementioning

confidence: 99%

“…bassiana filtrate had increased abundance of attacin C and decreased abundance of a defensin. Defensins are anti-bacterial peptides highly active against Gram-positive bacteria (Faruck et al 2016), they form voltage-dependent channels, leading to rapid leakage of K+ and other ions (Hoffmann 1995). A coleoptericin was increased in abundance in M. brunneum and B. bassiana treated larvae relative to B. caledonica treated larvae (Figure 3).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The effect of entomopathogenic fungal culture filtrate on the immune response and haemolymph proteome of the large pine weevil, Hylobius abietis

Namara

Griffin

Fitzpatrick

et al. 2018

Insect Biochemistry and Molecular Biology

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The large pine weevil Hylobius abietis L. is a major forestry pest in 15 European countries, where it is a threat to 3.4 million hectares of forest. A cellular and proteomic analysis of the effect of culture filtrate of three entomopathogenic fungi (EPF) species on the immune system of H. abietis was performed. Injection with Metarhizium brunneum or Beauvaria bassiana culture filtrate facilitated a significantly increased yeast cell proliferation in larvae. Larvae co-injected with either Beauvaria caledonica or B. bassiana culture filtrate and Candida albicans showed significantly increased mortality. Together these results suggest that EPF culture filtrate has the potential to modulate the insect immune system allowing a subsequent pathogen to proliferate. Injection with EPF culture filtrate was shown to alter the abundance of protease inhibitors, detoxifing enzymes, antimicrobial peptides and proteins involved in reception/detection and development in H. abietis larvae. Larvae injected with B. caledonica culture filtrate displayed significant alterations in abundance of proteins involved in cellulolytic and other metabolic processes in their haemolymph proteome. Screening EPF for their ability to modulate the insect immune response represents a means of assessing EPF for use as biocontrol agents, particularly if the goal is to use them in combination with other control agents.

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“…The main concern in treating fungal infections is that any chemical substance that is successful in damaging the eukaryotic cell wall of fungi may also cause possible damage to human cells, unlike antibiotics, which won't have any effect on humans. Any chemical substance that is toxic to fungus may also be toxic to humans (Mohammad et al, 2015). Therefore, there is need to discover new biochemical targets in fungi.…”

Section: Introductionmentioning

confidence: 99%

“…Antifungal peptides from natural sources are much cheaper than commercial antifungal drugs and are also better alternative to combat resistance. Antifungal peptides are cationic biomolecules with weight around 1.3 kDa to 30 kDa (Mohammad et al, 2015). Antifungal peptides are classifi ed into two types based on their mode of action.…”

Section: Introductionmentioning

confidence: 99%

Antifungal peptides: Biosynthesis, production and applications

Mirza¹,

Motamarry²,

Bhadra³

et al. 2018

Biosci. Biotech. Res. Comm

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Fungal infections in animal, plants and fungal contamination of food for humans and livestock result in substantial worldwide economic losses. In the last few years, fungal infection has increased strikingly by a rise in the number of deaths of acquired immunodefi ciency syndrome (AIDS) cancer patients, transplant patients owing to fungal infections. The growth rate of fungi is very slow as compared to bacteria and very diffi cult to identify. Approximately 100 peptides have been investigated to date for their antifungal properties, which can be of great importance to overcome the human diseases. Insects secrete such compounds, which can be peptides, as a part of their immune defense reactions. Antifungal peptides are excellent models for drug discovery exhibiting unique characteristics such as high specifi city, broad spectrum, low level of resistance reaching and unique mode of action. The aim of this review is to provide information on research on these important peptides.

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An overview of antifungal peptides derived from insect

Cited by 76 publications

References 107 publications

Natural Antifungal Peptides/Proteins as Model for Novel Food Preservatives

Natural Antifungal Peptides/Proteins as Model for Novel Food Preservatives

The effect of entomopathogenic fungal culture filtrate on the immune response and haemolymph proteome of the large pine weevil, Hylobius abietis

Antifungal peptides: Biosynthesis, production and applications

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