An Overview of Colorectal Cancer Screening

Goodbrand, Sarah A.; Steele, Robert

doi:10.1258/rsmsmj.53.4.31

Cited by 4 publications

(4 citation statements)

References 82 publications

(123 reference statements)

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“…It is interesting to note that approximately 30% of the subject referrals for diagnostic colonoscopy were for benign indications such as "abnormal bowel habits," signifying the clinical need for tests that aid in CRC diagnosis. The prevalence of CRC screening populations in Europe is estimated at approximately 0.7% (30), indicating a >15-fold enrichment for CRC samples. In addition, the detailed recording of subject comorbidities and diagnostic outcomes enables additional studies for related indications and CRC diagnostic test intent-to-test parameters.…”

Section: Discussionmentioning

confidence: 99%

Discovery and Validation of Plasma-Protein Biomarker Panels for the Detection of Colorectal Cancer and Advanced Adenoma in a Danish Collection of Samples from Patients Referred for Diagnostic Colonoscopy

Blume

Wilhelmsen

Benz

et al. 2016

The Journal of Applied Laboratory Medicine

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Background:Well-collected and well-documented sample repositories are necessary for disease biomarker development. The availability of significant numbers of samples with the associated patient information enables biomarker validation to proceed with maximum efficacy and minimum bias. The creation and utilization of such a resource is an important step in the development of blood-based biomarker tests for colorectal cancer. Methods: We have created a subject data and biological sample resource, Endoscopy II, which is based on 4698 individuals referred for diagnostic colonoscopy in Denmark between May 2010 and November 2012. Of the patients referred based on 1 or more clinical symptoms of colorectal neoplasia, 512 were confirmed by pathology to have colorectal cancer and 399 were confirmed to have advanced adenoma. Using subsets of these sample groups in case-control study designs (300 patients for colorectal cancer, 302 patients for advanced adenoma), 2 panels of plasma-based proteins for colorectal cancer and 1 panel for advanced adenoma were identified and validated based on ELISA data obtained for 28 proteins from the samples. Results: One of the validated colorectal cancer panels was comprised of 8 proteins (CATD, CEA, CO3, CO9, SEPR, AACT, MIF, and PSGL) and had a validation ROC curve area under the curve (AUC) of 0.82 (CI 0.75-0.88). There was no significant difference in the performance between early-and late-stage cancer. The advanced adenoma panel was comprised of 4 proteins (CATD, CLUS, GDF15, SAA1) and had a validation ROC curve AUC of 0.65 (CI 0.56 -0.74). Conclusions: These results suggest that the development of blood-based aids to colorectal cancer detection and diagnosis is feasible.

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Section: Discussionmentioning

confidence: 99%

Discovery and Validation of Plasma-Protein Biomarker Panels for the Detection of Colorectal Cancer and Advanced Adenoma in a Danish Collection of Samples from Patients Referred for Diagnostic Colonoscopy

Blume

Wilhelmsen

Benz

et al. 2016

The Journal of Applied Laboratory Medicine

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show abstract

“…2) and hence misses tumours located in the transverse and ascending colon and the caecum. It has a reported sensitivity of 69% and specificity of 95% in determining the presence or absence of disease (Goodbrand, 2008).…”

Section: Current Screening Methodsmentioning

confidence: 99%

The discovery and validation of colorectal cancer biomarkers

Phung

Nice

2010

Biomedical Chromatography

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Colorectal cancer is currently the third most common malignancy in the world. Patients have excellent prognosis following surgical resection if their tumour is still localized at diagnosis. By contrast, once the tumour has started to metastasize, prognosis is much poorer. Accurate early detection can therefore significantly reduce the mortality from this disease. However, current tests either lack the required sensitivity and selectivity or are costly and invasive. Improved biomarkers, or panels of biomarkers, are therefore urgently required. We have addressed current screening strategies and potential protein biomarkers that have been proposed. The role of both discovery and hypothesis-driven proteomics approaches for biomarker discovery and validation is discussed. Using such approaches we show how multiple reaction monitoring (MRM) can be successfully developed and used for quantitative multiplexed analysis of potential faecal biomarkers.

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“…About 70% of all tumors deaths occurred according to income level were in low-and middle-income countries, and these figures are getting higher [3]. Deaths from the different types of cancers internationally are anticipated to rise over 13.1 million in 2030 [4].…”

Section: Introductionmentioning

confidence: 99%

Lack of Knowledge and Negative Beliefs about Colorectal Cancer: FOBT and Dietary Risk Factors in Makkah, KSA

Bukhari¹

2018

ujph

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Colorectal cancer (CRC) is the third most common disease in males and second in females. A negative attitude about information such as prevalence, screening tests and poor dietary factors might increase risk. The aim was to measure knowledge and beliefs about screening test and some dietary factors. A cross-sectional study with 2564 participants was done. A validated questionnaire was used. SPSS (version 16) was used. The majority (60-80%) did not have knowledge about the risk of CRC. Only 25% knew it is widely occurring, about22% knew it is higher in western society. Only about 5% men and 13% women realized the correct order to have CRC for their gender. Of total, 21% recognized that it is most common in men, yet, men scored better than women (23% vs 18%). Approximately 12% vs 17%, of men and women resp, have chosen FOBT as the screening test for CRC. Both genders understand the role of high fiber to reduce CRC (54% vs63% men and women resp). In comparison, only about 10-13% of both genders do not believe that nor does cooking type neither obesity affect CRC risk negatively. More health programs to increase the awareness and changing wrong beliefs should be done.

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An Overview of Colorectal Cancer Screening

Cited by 4 publications

References 82 publications

Discovery and Validation of Plasma-Protein Biomarker Panels for the Detection of Colorectal Cancer and Advanced Adenoma in a Danish Collection of Samples from Patients Referred for Diagnostic Colonoscopy

Discovery and Validation of Plasma-Protein Biomarker Panels for the Detection of Colorectal Cancer and Advanced Adenoma in a Danish Collection of Samples from Patients Referred for Diagnostic Colonoscopy

The discovery and validation of colorectal cancer biomarkers

Lack of Knowledge and Negative Beliefs about Colorectal Cancer: FOBT and Dietary Risk Factors in Makkah, KSA

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