An overview of detection techniques for monitoring dioxin-like compounds: latest technique trends and their applications

Abstract

Dioxin-like compounds (DLCs) are considered persistent bioaccumulative toxicants with a number of continuing issues in the fields of ecotoxicology and bioassay. In spite of the great need to monitor these compounds, the only analytical technique with sufficient sensitivity and selectivity for determination of DLCs is a combination of high-resolution gas chromatography and high-resolution mass spectrometry.However, these methods require aseptic techniques, long incubation times, and sophisticated technical expertise for getting accurate results. Nowadays, biological techniques such as biomarkers, bioassays, enzyme immunoassays (EIAs), or other methods have been greatly developed as more sensitive, costeffective and rapid techniques to determine the presence of DLCs in trace levels of environmental and biological samples. The main aim of this study is to review the latest analytical and bioanalytical detection methods (BDMs) for diagnosis and monitoring of DLCs. Likewise, this work characterizes the latest techniques and trends based on their application, advantages and shortcomings for the various BDMs and their differences are also noted.

A stable zirconium based metal-organic framework for specific recognition of representative polychlorinated dibenzo-p-dioxin molecules

“…34), the detection limits (3S b /K sv ) of BUT-17 toward BCDD and TCDD in hexane were calculated to be 0.11 and 0.18 μ M (corresponding to 27 and 57 ppb), respectively. It should be pointed that, till now, the detection of PCDDs is mainly based on analytical method such as high-resolution gas chromatography tandem high-resolution mass spectrometry (HRGC-HRMS) and bio-analytical methods such as biomarkers, bioassays, and enzyme immunoassays (EIAs) 44 . These methods are highly sensitive toward PCDDs and the detection limits toward PCDDs are low at part per trillion (ppt) level.…”

Formation, Measurement, and Control of Dioxins from the Incineration of Municipal Solid Wastes: Recent Advances and Perspectives

“…The principle of bioanalytical detection methods (BDMs) is the ability to identify the unique structural properties of the dioxin-like compounds by hinge biomolecules and based on special reactions to dioxin-like compounds by cells or organisms . Compared to the traditional methods using HRGC/HRMS, BDMs are rapid and low cost, which mainly include the enzyme immunoassay (EIA) and bioassays based on the molecular function of aryl hydrocarbon receptors (AhRs).…”

Simulating Detection of Dioxin-like Pollutants with 2D Surface Enhanced Raman Spectroscopy using h-BNC Substrates

“…Detection of dioxins and dibenzofurans is therefore a priority to prevent environment contamination and protect living organisms from their damages. The classical methods for detection of dioxin-like compounds are mainly classified as biological or chemical techniques [15]. Biological methods are based on in vivo or in vitro bioassays and protein binding assays [16][17][18][19][20], whereas chemical methods are based on gas chromatography and mass spectrometry [21][22][23][24][25].…”

“…Therefore, SERS technique has been pointed out as one of the most promising alternatives for POPs detection [28,[33][34][35][36][37][38][39][40][41][42][43][44], mainly due to the very low detection limits obtained [45], limits unreachable with traditional detection procedures based on bioassays or chromatography techniques. Another advantage of spectroscopic techniques in general and SERS in particular is the lower costs compared to bioassays and gas chromatography [15]; costs that have been reduced gradually by improving the fabrication techniques of SERS substrates or replacing the traditional gold and silver nanoparticles by less expensive nanostructured materials [55][56][57][58][59].…”