An Overview of Laryngeal Cancer Treatment at a Tertiary Care Oncological Center in a Developing Country

Adeel, Mohammad; Faisal, Muhammad; Rashid, Asma; Usman, Sadaf; Khaleeq, Usman; Abbas, Taskheer; Rehman, Abdul; Malik, Kashif; Hussain, Raza; Jamshed, Arif

doi:10.7759/cureus.2730

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…[19][20][21] It has been found in the study of Adeel et al that 93.5% of the cases were male. [22] On the other side, Gupta et al have determined that 80% of the cases were male in their study. [23] In our study, 96.8% of the patients were male without nationality differentiation and male/ female gender ratio was compliant with literature.…”

Section: Discussionmentioning

confidence: 97%

Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations

Gürsoy

Seçinti

DORAN>

et al. 2022

Journal of Contemporary Medicine

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Objectives: This study aimed to identify the differences between the tumors and their histopathological characteristics in the materials obtained by laryngectomy performed because of laryngeal squamous cell carcinoma (LSCC) in Turkish and Syrian patient populations. Material and Method: Our study has a retrospective design. The present study included all the patients who were diagnosed with squamous cell carcinoma between January 2010 to January 2021 and underwent laryngectomy in our institute. Medical records, pathology and radiology reports were reviewed. Demographic and histopathological factors were statistically compared between Turkish and Syrian groups. Results: Of 93 cases included in our study, 53 (57%) were Syrian while 40 (43%) were Turkish citizens. We have determined no statistically significant difference between two patient groups. Conclusions: Hatay is a geography that Syrians were familiar with its culture before the war and both societies are exposed to the same environmental conditions. Therefore, we might have found no significant difference between the demographic and histopathological characteristics of laryngeal cancer in Turkish and Syrian patient populations.

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Section: Discussionmentioning

confidence: 97%

Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations

Gürsoy

Seçinti

DORAN>

et al. 2022

Journal of Contemporary Medicine

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“…This led to many operable diseases progressing to inoperable stages. For those patients who did undergo salvage TL, the disease recurred in around 43.3% of cases [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer

et al. 2023

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Background: Various factors can affect the survival of patients with laryngeal cancer (LC). In this retrospective study, we assessed clinicopathological features, their prognostic value, and treatment modalities for patients with confirmed squamous cell LC. Methods: We collected patient data on demographics, clinicopathological characteristics, treatment patterns, and outcomes. The primary endpoints were overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and locoregional control (LRC). We assessed survival using the Kaplan–Meier method and Cox regression model analyses of potential prognostic parameters. Results: After a median follow-up of 76 months, 28 (33.3%) patients had a recurrence. The median OS was 78 months, with an event recorded in 50% of patients. The DSS median was not reached (NR) with a survival rate of 72.6%, the DFS survival rate was 66.7% with median NR, and the LRC survival rate was 72.6% with median NR. After conducting a multivariate analysis of significant variables, we found that only recurrence and lymphatic invasion had an independent effect on OS and recurrence in DSS, while subsite impacted DFS and LRC. Conclusions: Survival trends were consistent with other studies, except for OS. Recurrence, lymphatic invasion, and subsite location were significant factors that impacted patient survival.

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“…However, the most important factors are the dimensions of the tumor, its location, and stage [1,2]. In the case of advanced lesions (T3 and T4 grade of the TNM scale), laryngectomy and laser microsurgery supported by radiotherapy or chemotherapy are most often used [12,13]. Advances in genetics has led to the development of predictive biomarkers and targeted therapies that help in diagnosis and treatment [11].…”

Section: Introductionmentioning

confidence: 99%

CLINICAL ROLE OF miRNA BIOMARKERS IN LARYNGEAL SQUAMOUS CELL CARCINOMA (LSCC): LITERATURE REVIEW

Rusinowska,

Tybulczuk

2023

J Hear Sci

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IntroductionMalignant transformations may result from gene dysregulation caused by genetic and epigenetic modifications. The use of miRNAs to treat cancer depends on the downregulation or upregulation of the miRNAs responsible for carcinogenesis (proliferation, angiogenesis, invasion, metastasis), providing the opportunity to suppress tumors. The purpose of this review is to list miRNAs identified so far as biomarkers in laryngeal squamous cell carcinoma (LSCC). This listing may help in predicting the evolution of miRNAs and developing anti-miRNAs and miRNA-mimics as anti-cancer therapies.Material and methodsRelevant publications from 2008 to 2022 were retrieved from the PubMed and Google Scholar databases, using the key words miRNA (PubMed – 149,294 results; Google Scholar – 205,000 results), laryngeal squamous cell carcinoma (PubMed – 33,191 results; Google Scholar – 17,900 results), laryngeal squamous cell carcinoma biomarkers (PubMed – 6249 results; Google Scholar – 18,000 results), laryngeal squamous cell carcinoma miRNA (PubMed – 1338 results; Google Scholar – 17,500 results). Eventually 51 papers were selected for review.ResultsWe identified 51 studies which have detected miRNA-based biomarkers for LSCC, and they are broadly reviewed here.ConclusionsThe identified laryngeal squamous cell-specific miRNA biomarkers appear to be promising for the detection, predicted course, and treatment of LSCC.

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An Overview of Laryngeal Cancer Treatment at a Tertiary Care Oncological Center in a Developing Country

Cited by 6 publications

References 27 publications

Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations

Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations

Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer

CLINICAL ROLE OF miRNA BIOMARKERS IN LARYNGEAL SQUAMOUS CELL CARCINOMA (LSCC): LITERATURE REVIEW

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