An Overview of Literature Topics Related to Current Concepts, Methods, Tools, and Applications for Cumulative Risk Assessment (2007–2016)

Fox, Mary A.; Brewer, L. Elizabeth; Martin, Lawrence

doi:10.3390/ijerph14040389

Cited by 36 publications

(22 citation statements)

References 145 publications

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“…To assess combined exposures to multiple phthalates, the Hazard Index (HI) was used, which is based on the dose addition concept [ 7 , 69 , 70 ]. The following Equation was applied to determine the values HI for participant i and phthalate j for N phthalates (4):

where EDI is the estimated daily intake of phthalate (μg/kg body weight/day), and n is the number of substances in the mixture.…”

Section: Methodsmentioning

confidence: 99%

Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

Jeddi

Gorji

Rietjens

et al. 2018

IJERPH

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This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolescents aged 6 to 18 years by analyzing seven urinary metabolites of five phthalates. The estimated daily intake values derived from the biomonitoring data ranged from 0.01 µg/kg bw/day for butyl benzyl phthalate (BBP), to 17.85 µg/kg bw/day for di(2-ethylhexyl) phthalate (DEHP). The risk assessment revealed that not only the exposure to the individual phthalates, but also the combined exposure to the three anti-androgenic phthalates (DEHP, DBP, BBP) did not raise a safety concern (hazard index values averaged 0.2). The range of maximum cumulative ratio values varied from around 1 for most individuals to around 2 in some individuals, indicating that the combined exposures were dominated by one and in some cases by two of the three anti-androgenic phthalates, especially dibutyl phthalate (DBP) and/or DEHP. Based on biomonitoring data, the overall combined exposure of Iranian children to phthalates does not raise a concern, while reduction of exposure is best focused on DEHP and DBP that showed the highest hazard quotient.

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where EDI is the estimated daily intake of phthalate (μg/kg body weight/day), and n is the number of substances in the mixture.…”

Section: Methodsmentioning

confidence: 99%

Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

Jeddi

Gorji

Rietjens

et al. 2018

IJERPH

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“…Cumulative risk assessment has become an increasingly common approach for assessing chemical hazards and is beginning to be used more frequently to quantifying the risk associated with nonchemical stressors (for example, radiation, biological, psychological, and so forth) [ 41 , 42 , 43 ]. The CRA approach has been regularly used to assess the cumulative risk of pesticides [ 42 ], as well as phthalates [ 43 ] and air pollutants (including pollutants generated from industrial agricultural operations) [ 42 , 43 ]. The CRA approach was used in the National-Scale Air Toxics Assessment, which attempted to estimate the cancer and non-cancer health effects of joint exposure to air toxics across the United States [ 42 ].…”

Section: Application Of Assessment Methods To Agricultural Productmentioning

confidence: 99%

A Review of Methods for Assessing the Environmental Health Impacts of an Agricultural System

Grout

Hales

French

et al. 2018

IJERPH

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(1) Background: Global agricultural production is projected to increase substantially in the coming decades. Agricultural production provides food and materials crucial to human survival and well-being and is a critical source of livelihood, providing employment opportunities and economic benefits. However, industrialized or intensified agricultural systems, in particular, can have adverse effects on public health, place pressure on natural resources, and reduce environmental sustainability. This review attempts to identify and characterize key environmental health assessment methods for examining a broad array of potential impacts; (2) Methods: Electronic databases Medline, Scopus, Web of Science, and GreenLINE were searched for published literature that presented methods for conducting an environmental health assessment of an agricultural system; (3) Results: Fifty-three sources were included in the review. Eight methods were selected to illustrate the wide range of approaches currently available: health risk assessment methods, health impact assessment, environmental impact assessment methods, environmental burden of disease, lifecycle methods, integrated assessment modeling, trade-off analysis, and economic assessment; (4) Conclusions: This review can provide guidance for selecting an existing method or for designing a new method for assessing the environmental health impacts of an agricultural system.

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“…And finally, indications that this field of research may be making progress in establishing its own niche include discussions in various review articles ( Eggimann et al, 2017 ; Fox et al, 2017 ; Gracia-Lor et al, 2017 ; Ort et al, 2013 ).…”

Section: Update On Published Advancements Relevant To Bioscimmentioning

confidence: 99%

Monitoring wastewater for assessing community health: Sewage Chemical-Information Mining (SCIM)

Daughton

2018

Science of The Total Environment

162

118

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Timely assessment of the aggregate health of small-area human populations is essential for guiding the optimal investment of resources needed for preventing, avoiding, controlling, or mitigating human exposure risks, as well as for maintaining or promoting health. Seeking those interventions yielding the greatest benefit with respect to the allocation of resources is critical for making progress toward community sustainability, reducing health disparities, promoting social justice, and maintaining or improving collective health and well-being. More informative, faster, and less-costly approaches are needed for guiding investigation of cause-effect linkages involving communities and stressors originating from both the built and natural environments. One such emerging approach involves the continuous monitoring of sewage for chemicals that serve as indicators of the collective status of human health (or stress/disease) or any other facet relevant to gauging time-trends in community-wide health. This nascent approach can be referred to as Sewage Chemical-Information Mining (SCIM) and involves the monitoring of sewage for the information that resides in the form of natural and anthropogenic chemicals that enter sewers as a result of the everyday actions, activities, and behaviors of humans. Of particular interest is a specific embodiment of SCIM that would entail the targeted monitoring of a broad suite of endogenous biomarkers of key physiologic processes (as opposed to xenobiotics or their metabolites). This application is termed BioSCIM—an approach roughly analogous to a hypothetical community-wide collective clinical urinalysis, or to a hypothetical en masse human biomonitoring program. BioSCIM would be used for gauging the status or time-trends in community-wide health on a continuous basis. This paper presents an update on the progress made with the development of the BioSCIM concept in the period of time since its original publication in 2012, as well as the next steps required for its continued development.

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An Overview of Literature Topics Related to Current Concepts, Methods, Tools, and Applications for Cumulative Risk Assessment (2007–2016)

Cited by 36 publications

References 145 publications

Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

A Review of Methods for Assessing the Environmental Health Impacts of an Agricultural System

Monitoring wastewater for assessing community health: Sewage Chemical-Information Mining (SCIM)

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