The principal goal of this research is developing physics-based, reduced-order, analytical models of nonlinear fluid-structure interactions associated with offshore structures. Our primary focus is to generalize the Hamilton's variational framework so that systems of flowoscillator equations can be derived from first principles. This is an extension of earlier work that led to a single energy equation describing the fluid-structure interaction. It is demonstrated here that flow-oscillator models are a subclass of the general, physical-based framework. A flow-oscillator model is a reduced-order mechanical model, generally comprising two mechanical oscillators, one modelling the structural oscillation and the other a nonlinear oscillator representing the fluid behaviour coupled to the structural motion.Reduced-order analytical model development continues to be carried out using a Hamilton's principle-based variational approach. This provides flexibility in the long run for generalizing the modelling paradigm to complex, three-dimensional problems with multiple degrees of freedom, although such extension is very difficult. As both experimental and analytical capabilities advance, the critical research path to developing and implementing fluid-structure interaction models entails -formulating generalized equations of motion, as a superset of the flow-oscillator models; and -developing experimentally derived, semi-analytical functions to describe key terms in the governing equations of motion. The developed variational approach yields a system of governing equations. This will allow modelling of multiple d.f. systems. The extensions derived generalize the Hamilton's variational formulation for such problems. The Navier-Stokes equations are derived and coupled to the structural oscillator. This general model has been shown to be a superset of the flow-oscillator model. Based on different assumptions, one can derive a variety of flowoscillator models.