An overview of mosquito vectors of Zika virus

Boyer, Sébastien; Calvez, Elodie; Chouin-Carneiro, Thaís; Diallo, Diawo; Failloux, Anna‐Bella

doi:10.1016/j.micinf.2018.01.006

Cited by 152 publications

(172 citation statements)

References 137 publications

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“…Although the number of ZIKV cases have subsided, ZIKV remains a significant threat due to the sporadic and unpredictable nature of its outbreak. In addition, ZIKV shares the same vectors with another widespread flavivirus, DENV [93], which is projected to increase exponentially in the future [94]. Thus, the potential re-occurrence of outbreaks, coupled with devastating neurological complications, warrants for extensive research to completely understand the virus pathophysiology for antiviral drug development.…”

Section: Resultsmentioning

confidence: 99%

Endoplasmic reticulum: a focal point of Zika virus infection

et al. 2020

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Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family. It is an arbovirus that can cause congenital abnormalities and is sexually transmissible. A series of outbreaks accompanied by unexpected severe clinical complications have captured medical attention to further characterize the clinical features of congenital ZIKV syndrome and its underlying pathophysiological mechanisms. Endoplasmic reticulum (ER) and ER-related proteins are essential in ZIKV genome replication. This review highlights the subcellular localization of ZIKV to the ER and ZIKV modulation on the architecture of the ER. This review also discusses ZIKV interaction with ER proteins such as signal peptidase complex subunit 1 (SPCS1), ER membrane complex (EMC) subunits, and ER translocon for viral replication. Furthermore, the review covers several important resulting effects of ZIKV infection to the ER and cellular processes including ER stress, reticulophagy, and paraptosis-like death. Pharmacological targeting of ZIKVaffected ER-resident proteins and ER-associated components demonstrate promising signs of combating ZIKV infection and rescuing host organisms from severe neurologic sequelae.

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Section: Resultsmentioning

confidence: 99%

Endoplasmic reticulum: a focal point of Zika virus infection

et al. 2020

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“…In recent years Zika (ZIK) virus pathogen, vectored by Ae. aegypti, has emerged as a major vector-borne disease, reaching Latin America and by 2017 impacting over 30 American countries (Zanluca et al, 2015;Boyer et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The challenge of invasive mosquito vectors in the U.K. during 2016–2018: a summary of the surveillance and control of Aedes albopictus

Vaux

Dallimore

Cull

et al. 2019

Medical Vet Entomology

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Mosquito‐borne diseases resulting from the expansion of two key vectors, Aedes aegypti and Aedes albopictus (Diptera: Culicidae), continue to challenge whole regions and continents around the globe. In recent years there have been human cases of disease associated with Chikungunya, dengue and Zika viruses. In Europe, the expansion of Ae. albopictus has resulted in local transmission of Chikungunya and dengue viruses. This paper considers the risk that Ae. aegypti and Ae. albopictus represent for the U.K. and details the results of mosquito surveillance activities. Surveillance was conducted at 34 points of entry, 12 sites serving vehicular traffic and two sites of used tyre importers. The most common native mosquito recorded was Culex pipiens s.l. (Diptera: Culicidae). The invasive mosquito Ae. albopictus was detected on three occasions in southern England (September 2016, July 2017 and July 2018) and subsequent control strategies were conducted. These latest surveillance results demonstrate ongoing incursions of Ae. albopictus into the U.K. via ground vehicular traffic, which can be expected to continue and increase as populations in nearby countries expand, particularly in France, which is the main source of ex‐continental traffic.

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“…Ectoparasites act as vectors for many notable viral pathogens of vertebrates, including Zika virus, dengue virus, and tick-borne encephalitis virus (Boyer, Calvez, Chouin-Carneiro, Diallo, & Failloux, 2018; Lindquist & Vapalahti, 2008; Rodhain, 2015). Transmission can occur “biologically”, with active virus replication in the ectoparasite, or “mechanically” without ectoparasite replication (Chihota, Rennie, Kitching, & Mellor, 2001; Kuno & Chang, 2005; McColl et al, 2002; Rodhain, 2015).…”

Section: Introductionmentioning

confidence: 99%

Limited overlap in RNA virome composition among rabbits and their ectoparasites reveals barriers to virus transmission

Mahar

Shī

Hall

et al. 2019

Preprint

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Ectoparasites play an important role in virus transmission among vertebrates. However, little is known about the extent and composition of viruses that pass between invertebrates and vertebrates. In Australia, flies and fleas support the mechanical transmission of viral biological controls against wild rabbits - rabbit haemorrhagic disease virus (RHDV) and myxoma virus. We compared virome structure and composition in rabbits and these associated ectoparasites, sequencing total RNA from multiple tissues and gut contents of wild rabbits, fleas collected from these rabbits, and flies trapped sympatrically. Meta-transcriptomic analyses identified 50 novel viruses from multiple RNA virus families. Rabbits and their ectoparasites were characterised by markedly different viromes: although viral contigs from six virus families/groups were found in both rabbits and ectoparasites, none were vertebrate-associated. A novel calicivirus and picornavirus detected in rabbit caecal content were vertebrate-specific: the newly detected calicivirus was distinct from known rabbit caliciviruses, while the novel picornavirus clustered with the Sapeloviruses. Several Picobirnaviridae were also identified, falling in diverse phylogenetic positions suggestive of an association with co-infecting bacteria. The remaining viruses found in rabbits, and all those from ectoparasites, were likely associated with invertebrates, plants and co-infecting endosymbionts. While no full genomes of vertebrate-associated viruses were detected in ectoparasites, suggestive of major barriers to biological transmission with active replication, small numbers of reads from rabbit astrovirus, RHDV and other lagoviruses were present in flies. This supports the role of flies in the mechanical transmission of RHDV and implies that they may assist the spread of astroviruses.

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An overview of mosquito vectors of Zika virus

Cited by 152 publications

References 137 publications

Endoplasmic reticulum: a focal point of Zika virus infection

Endoplasmic reticulum: a focal point of Zika virus infection

The challenge of invasive mosquito vectors in the U.K. during 2016–2018: a summary of the surveillance and control of Aedes albopictus

Limited overlap in RNA virome composition among rabbits and their ectoparasites reveals barriers to virus transmission

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