An Overview of Obesity, Cholesterol, and Systemic Inflammation in Preeclampsia

Alston, Morgan; Redman, Leanne M.; Sones, Jenny L.

doi:10.3390/nu14102087

Cited by 31 publications

(27 citation statements)

References 53 publications

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“…The correlation heat map further confirmed that cholesterol was negatively correlated with acetic acid and propionic acid levels. Another study found that increased adipose tissue and cholesterol in pregnant women promoted metabolic abnormalities and systemic inflammation, leading to poor placental vascularization and promoting the occurrence of PE ( Alston et al., 2022 ). The reason for this difference may be related to dyslipidemia of pregnancy (DLP) caused by insulin resistance, increased lipoprotein synthesis, and lipolysis during normal pregnancy in the NP group ( Gao et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of short-chain fatty acids in pregnancy complications

Chen

Ren

et al. 2023

Front. Cell. Infect. Microbiol.

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ObjectiveTo investigate the expression of short-chain fatty acids (SCFAs)—metabolites of intestinal flora—in gestational complications of gestational diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis of pregnancy (ICP), and its clinical significance.MethodsTargeted metabonomics was used to detect SCFAs in the serum of 28 GDM pregnant women, 28 PE pregnant women, 29 ICP pregnant women, and 27 healthy pregnant women (NP); their expression changes were observed; the correlation between SCFAs and clinical characteristics was studied; and their potential as biomarkers for clinical diagnosis was evaluated.ResultsThere were significant differences in the SCFA metabolic spectrum between the GDM, PE, ICP, and NP groups. Quantitative analysis showed that the content of isobutyric acid in the three pregnancy complications groups (the GDM, PE, and ICP groups) was significantly higher than that in the NP group (p < 0.05), and other SCFAs also showed significant differences in the three pregnancy complications groups compared with the NP group (p < 0.05). Receiver operating characteristic (ROC) curve analysis of the generalized linear model showed that multiple SCFAs were highly sensitive and specific as diagnostic markers in the pregnancy complications groups, where isobutyric acid was highly predictive in GDM (area under the ROC curve (AUC) = 0.764) and PE (AUC = 1), and caproic acid was highly predictive in ICP (AUC = 0.968), with potential clinical application.ConclusionThe metabolic products of intestinal flora, SCFAs, during pregnancy are closely related to pregnancy complications (GDM, PE, and ICP), and SCFAs can be used as potential markers of pregnancy complications.

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Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of short-chain fatty acids in pregnancy complications

Chen

Ren

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Ожиріння пов'язане з підвищеним ризиком ряду серйозних несприятливих наслідків. За сучасними даними, ускладнення ґестаційного процесу у жінок з ожирінням відзначаються у 45-85% випадків [8]. MBRRACE 2015 виявив, що більше половини жінок, які померли прямо чи опосередковано від причин, пов'язаних з вагітністю, мали надлишкову вагу або ожиріння [21].…”

Section: метаболічні аспекти розвитку прееклампсіїunclassified

“…Біосинтез клітинного холестерину та гомеостаз холестерину підтримується переважно печінкою, але холестерин також зберігається в жировій тканині [18]. Останні дослідження показують, що жирова тканина служить основним місцем зберігання вільного холестерину, а збільшення накопичення холестерину паралельно з ожирінням [8,18]. При ожирінні приблизно 50% холестерину в організмі зберігається в жировій тканині.…”

Section: результати та їх обговоренняunclassified

“…Під час вагітності підвищення рівня холестерину у матері, яке часто називають фізіологічною гіперхолестеринемією матері (MГХ), є нормальною фізіологічною адаптацією для забезпечення правильного розвитку плода. Однак підвищення рівня холестерину під час вагітності, яке називають материнською супрафізіологічною гіперхолестеринемією (MСГХ), асоціюється із розвитком гестаційної ендотеліопатії та атеросклеротичним ураженням судинної системи плаценти [8]. Нормальна функція ендотелію та макрофагів залежить від диференційованого співвідношення між ЛПВЩ та ЛПНЩ.…”

Section: результати та їх обговоренняunclassified

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Тhe Metabolic Aspects of Preeclampsia Development

BODNARCHUK¹

2022

AAGU

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Complications associated with preeclampsia (PE) include fetal growth retardation, premature birth, prenatal and postpartum hemorrhage, perinatal loss, and more. Obese women have an increased risk of developing PE, probably due to impaired placental development due to altered metabolic homeostasis. The aim was to generalize current knowledge about the role of risk factors associated with obesity and hypercholesterolemia in PE with an emphasis on the results of preclinical models. Material and methods. In reviewing the literature, we used Medline systems from PubMed (2011). The search was adapted for Embase (2014-2022) and Scopus (2015-2022). The inclusion criteria were: the effect of obesity on pregnancy; experimental models of the pathogenesis of obesity during pregnancy; the features of predictive diagnosis of obese women at the stage of preconception and during pregnancy; features of antenatal care in obese women. The study was performed at Vinnytsya National Pirogov Memorial Medical University, according to research work № 0121U109141 “Optimization of early diagnosis and preventive treatment of perinatal complications caused by gestational endotheliopathy.” Results. Inflammatory cytokines from maternal adipose tissue and hypercholesterolemia have been associated with systemic inflammation, hypertension, and other adverse effects associated with PE. The main pathways of the negative influence of obesity on the genesis of PE were realized due to the manifested gestational endotheliopathy. Decreases in adipose tissue and associated adipokines were associated with optimization of placental angiogenesis and an overall improvement in the adverse effects associated with PE. Conclusions. Increased maternal adipose tissue mass and cholesterol levels contribute to metabolic disorders and systemic inflammation, which may contribute to the development of gestational endotheliopathy and subsequent abnormal placenta vascularization. Further research will need to further clarify the contribution of pharmacotherapy, as well as some lifestyle adjustments, including preconceptional weight loss and the results of PE in women at high risk of obesity.

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“…It has been suggested that chronic low-level inflammation is one of the most important causes of insulin resistance onset, since chronic exposure to pro-inflammatory cytokines can impair insulin signaling pathways and decrease insulin secretion from beta cells [ 5 ]. Inflammation is the result of cellular damage and characterizes many pathologies, including cancer [ 11 , 12 , 13 ] and immune diseases [ 14 ], but also pregnancy complications, such as preeclampsia and preterm birth [ 15 , 16 , 17 , 18 ]. Chronic low-grade inflammation is a pathological condition, playing an important role in the pathogenesis and progression of some pathologies, including GDM, metabolic syndrome, DM and cardiovascular diseases [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

HtrA1 in Gestational Diabetes Mellitus: A Possible Biomarker?

et al. 2022

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Background: The high-temperature requirement A 1 (HtrA1) is a multidomain secretory protein with serine-protease activity, expressed in many tissues, including placenta, where its expression is higher in the first trimester, suggesting an association of this serine protease in early phases of human placenta development. In this study, we evaluated maternal serum HtrA1 levels in the first and third trimester of gestation. In particular, we evaluated a possible role of HtrA1 as an early marker of gestational diabetes mellitus (GDM) in the first trimester of gestation. Methods: We evaluated HtrA1 serum levels in the third trimester (36–40 weeks) in normal pregnancies (n = 20) and GDM pregnancies (n = 20) by using ELISA analysis. Secondly, we performed the same analysis by using the first trimester sera (10–12 weeks) of healthy pregnant women that will develop a normal pregnancy (n = 210) or GDM (n = 28) during pregnancy. Results: We found that HtrA1 serum levels in the third trimester were higher in pregnancies complicated by GDM. Interestingly, higher HtrA1 serum levels were also found in the first trimester in women developing GDM later during the second–third trimester. No significant differences in terms of maternal age and gestational age were found between cases and controls. Women with GDM shown significantly higher pre-pregnancy BMI values compared to controls. Moreover, the probability of GDM occurrence significantly increased with increasing HtrA1 levels and BMI values. The ROC curve showed a good accuracy in predicting GDM, with an AUC of 0.74 (95%CI: 0.64–0.92). Conclusions: These results suggest an important role of HtrA1 as an early predictive marker of GDM in the first trimester of gestation, showing a significative clinical relevance for prevention of this disease.

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An Overview of Obesity, Cholesterol, and Systemic Inflammation in Preeclampsia

Cited by 31 publications

References 53 publications

Expression and clinical significance of short-chain fatty acids in pregnancy complications

Expression and clinical significance of short-chain fatty acids in pregnancy complications

Тhe Metabolic Aspects of Preeclampsia Development

HtrA1 in Gestational Diabetes Mellitus: A Possible Biomarker?

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