An Overview of Paroxetine in the Elderly

Dünner, David L.

doi:10.1159/000213617

Cited by 14 publications

(5 citation statements)

References 14 publications

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“…Treatment is also more likely to be complicated by adverse side effects and drug interactions than in younger patients. Studies in the elderly have shown paroxetine to be effective and well tolerated (Dunner, 1994). It has also been shown to have no disruptive effect on tests of cognitive and psychomotor performance in healthy (Kerr et al, 1992) or depressed elderly patients (Nebes et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance

Ridout

Meadows

Johnsen

et al. 2003

Human Psychopharmacology

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Section: Discussionmentioning

confidence: 99%

A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance

Ridout

Meadows

Johnsen

et al. 2003

Human Psychopharmacology

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“…The current recommended first-line therapy for depression in later life is a serotonin selective re-uptake inhibitor (SSRI) because in comparison to tricyclic antidepressants like nortriptyline, SSRIs are safer in overdose, better tolerated, and do not require monitoring blood levels or EKG analysis prior to initiation of therapy [for review, see Montgomery, 1998;Dunner, 1994]. Multiple clinical trials have found similar efficacy between SSRIs and TCAs in the acute treatment of geriatric depression, with SSRIs being better tolerated [for review, see Schneider, 1996].…”

Section: Introductionmentioning

confidence: 99%

Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly

et al. 2001

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Elderly depressed patients are vulnerable to recurrence of depression and benefit from long‐term antidepressant therapy. Physicians increasingly use selective serotonin re‐uptake inhibitors (SSRIs) as maintenance therapy, although in the absence of data showing that SSRIs are as efficacious as tricyclic antidepressants (TCAs) in the prevention of depression relapse and recurrence. Our objective was to evaluate, in an open trial, the efficacy of paroxetine versus nortriptyline for preventing recurrence of depression in the elderly. Elderly patients with major depression were randomly assigned in a double‐blinded fashion to receive either paroxetine or nortriptyline for the acute treatment of depression. Patients who did not respond or tolerate their assigned medications were crossed over openly to the comparator agent. Patients whose depression remitted continued antidepressant medication (paroxetine n = 38; nortriptyline n = 21) during an open 18‐month follow‐up study. We examined the rates of and times to relapse and to termination of treatment for any reason. Paroxetine (PX) and nortriptyline (NT) patients had similar rates of relapse (16% vs. 10%, respectively) and time to relapse (60.3 weeks vs. 58.8 weeks, respectively) over 18 months. A lower burden of residual depressive symptoms and side effects during continuation and maintenance treatment was evident in nortriptyline‐treated patients. Paroxetine and nortriptyline demonstrated similar efficacy in relapse and recurrence prevention in elderly depressed patients over an 18‐month period. Depression and Anxiety 13:38–44, 2001. © 2001 Wiley‐Liss, Inc.

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“…22 Elderly depressed patients may exhibit more cognitive impairment and social isolation and may complain less of dysphoric mood. The presentation of symptoms in an elderly depressed patient may be similar to or may differ from a younger depressed patient.…”

Section: Diagnosis and Evaluationmentioning

confidence: 99%

“…The presentation of symptoms in an elderly depressed patient may be similar to or may differ from a younger depressed patient. 22 Elderly depressed patients may exhibit more cognitive impairment and social isolation and may complain less of dysphoric mood. 23 The elderly may also be more somatically focused, experience a higher level of fatigue and psychomotor retardation, and complain more about loss of interest in usual activities.…”

Section: Diagnosis and Evaluationmentioning

confidence: 99%

Geriatric Depression

Cooke¹,

Tucker

2001

Journal of Pharmacy Practice

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in the elderly is more common than once thought, especially in nursing home settings, where as many as 25% of residents can exhibit signs and symptoms of depression. Depression in the elderly can have a significant impact on overall health and desired outcome. The depressed elderly patient has been shown to have worsened prognosis of concomitant medical conditions, increased use of health care, decreased recovery time, and more likelihood to experience accelerated physical deterioration. Suicide represents the most serious complication of depression of the older depressed individual. The elderly are at a disproportionate risk for suicide attempts and are more likely to be successful. Diagnosis should be made using Diagnostic and Statistical Manual of Mental Disorders (4th ed.) (DSM-IV) criteria, and clinicians should use standardized rating scales such as the Geriatric Depression Scale to assist in monitoring the severity of depressive symptoms and the efficacy of antidepressant treatment. Several treatment options are available to the clinician and include psychotherapy, electroconvulsive therapy, older antidepressants such as the tricyclics, and newer more tolerable therapies such as the serotonin reuptake inhibitors. Drug therapy should be individualized and should take into account the pharmacokinetic and pharmacodynamic changes that are associated with normal aging.

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An Overview of Paroxetine in the Elderly

Cited by 14 publications

References 14 publications

A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance

A placebo controlled investigation into the effects of paroxetine and mirtazapine on measures related to car driving performance

Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly

Geriatric Depression

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