An Overview of Properties and Analytical Methods for Lycopene in Organic Nanocarriers

Carvalho, Gabriela Corrêa; Sábio, Rafael Miguel; Chorilli, Marlus

doi:10.1080/10408347.2020.1763774

Cited by 19 publications

(52 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The exposure solutions were freshly prepared before use in the culture medium and sterilized by filtration. Neurons were incubated with lycopene for 4 h, then expose to lead acetate for 24 h. Doses used in this study were according to previous studies on the protection of lycopene in oxidative damage models and Pb toxicity models 32,51 …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria‐mediated apoptosis in cultured hippocampal neurons

Qu¹,

Ni²,

Guo³

et al. 2020

MedComm

View full text Add to dashboard Cite

Lead (Pb) exhibits serious adverse effects on the central nervous system, and the major pathogenic mechanism of Pb toxicity is oxidative stress. As one of the carotenoid family members with potent antioxidant properties, lycopene has shown its protections by inhibiting oxidative stress damage in numerous models of neurotoxicity. The current study was designed to explore the possible protective property in primary cultured rat hippocampal neurons challenged with Pb. We observed that 5 M lycopene pretreatment for 4 h efficiently ameliorated Pb-caused damage in cell viability, accumulation of reactive oxygen species (ROS), and apoptosis in a dose-dependent manner. Moreover, lycopene (5 M) attenuated the 50 M Pb-induced mitochondrial ROS production, improved the activities of mitochondrial respiratory chain enzymes and ATP production, and ameliorated the 50 M Pb-induced depolarization of mitochondrial membrane potential as well as opening of mitochondrial permeability transition pores. In addition, 5 M lycopene restored the imbalance of Bax/Bcl-2, inhibited translocation of cytochrome c, and reduced caspase-3 activation. Taken together, these findings indicate that lycopene antagonizes against Pb-induced neurotoxicity and the underlying mechanism probably involves reduction of mitochondrial oxidative damage and mitochondria-mediated apoptosis.

show abstract

Section: Methodsmentioning

confidence: 99%

“…Neurons were incubated with lycopene for 4 h, then expose to lead acetate for 24 h. Doses used in this study were according to previous studies on the protection of lycopene in oxidative damage models and Pb toxicity models. 32 , 51 …”

Section: Methodsmentioning

confidence: 99%

Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria‐mediated apoptosis in cultured hippocampal neurons

Qu¹,

Ni²,

Guo³

et al. 2020

MedComm

View full text Add to dashboard Cite

show abstract

“…Lycopene is a naturally occurring red pigment in tomatoes, watermelon, pink grapefruit, papaya, apricots, and guava [15]. The main sources of lycopene in the diet are tomatoes and tomato-based products (Table 1) [16,17].…”

Section: Introductionmentioning

confidence: 99%

Lycopene in the Prevention of Cardiovascular Diseases

Przybylska

Tokarczyk

2022

IJMS

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) are the leading cause of human mortality worldwide. Oxidative stress and inflammation are pathophysiological processes involved in the development of CVD. That is why bioactive food ingredients, including lycopene, are so important in their prevention, which seems to be a compound increasingly promoted in the diet of people with cardiovascular problems. Lycopene present in tomatoes and tomato products is responsible not only for their red color but also for health-promoting properties. It is characterized by a high antioxidant potential, the highest among carotenoid pigments. Mainly for this reason, epidemiological studies show a number of favorable properties between the consumption of lycopene in the diet and a reduced risk of cardiovascular disease. While there is also some controversy in research into its protective effects on the cardiovascular system, growing evidence supports its beneficial role for the heart, endothelium, blood vessels, and health. The mechanisms of action of lycopene are now being discovered and may explain some of the contradictions observed in the literature. This review aims to present the current knowledge in recent years on the preventive role of lycopene cardiovascular disorders.

show abstract

“…Technological strategies, such as the use of nanocarriers produced by biodegradable polymers, inorganic particles, lipids, and amphiphilic structures can control the drug delivery at the site of action without modifying the bioactivity and properties of the drug. In addition, drug doses and side effects may be decreased while the biological activity of drugs is improved (Araújo et al, 2021; Bonifácio et al, 2014; Carvalho et al, 2020; Carvalho, Sábio, & Chorilli, 2020).…”

Section: Introductionmentioning

confidence: 99%

Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years

Marena

Ramos

Carvalho

et al. 2022

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

Fungal infections are one of the main public health problems, especially in immunocompromised patients, nosocomial environments, patients with chronic diseases, and transplant recipients. These diseases are increasingly frequent and lethal because the microorganism has a high capacity to acquire resistance to available therapy. The main resistance factors are the emergence of new strains and the uncontrolled use of antifungals. It is, therefore, important to develop new methods that contribute to combating fungal diseases in the clinical area. Natural products have considerable potential for the development of new drugs with antifungal activity, mainly due to their biocompatibility and low toxic effect. This promising antimicrobial activity of natural products is mainly due to the presence of flavonoids, terpenes, and quinones, which explains their antifungal potential. Pharmaceutical nanotechnology has been explored to enhance the delivery, selectivity, and clinical efficacy of these products. Nanotechnological systems provide a safe and selective environment for various substances, such as natural products, improving antifungal activity. However, further safety experiments (in vivo or clinical trials) need to be carried out to prove the therapeutic action of natural products, since they may have undesirable, toxic, and mutagenic effects. Therefore, this review article addresses the main nanotechnological methods using natural products for effective future treatment against the main fungal diseases.

show abstract

An Overview of Properties and Analytical Methods for Lycopene in Organic Nanocarriers

Cited by 19 publications

References 84 publications

Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria‐mediated apoptosis in cultured hippocampal neurons

Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria‐mediated apoptosis in cultured hippocampal neurons

Lycopene in the Prevention of Cardiovascular Diseases

Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years

Contact Info

Product

Resources

About