An Overview of SARS-CoV-2 (COVID-19) Infection and the Importance of Molecular Hydrogen as an Adjunctive Therapy

Russell, G.; Rehman, Mubasher; LeBaron, Tyler W.; Veal, David; Adukwu, Emmanuel; Hancock, John T.

doi:10.20455/ros.2020.829

Cited by 15 publications

(21 citation statements)

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“…response can proceed in a cyclical manner, wherein ROS promotes inflammatory response and inflammation produces more ROS. This is one of the mechanisms of parenchymal tissue damage in the patient (54). Therefore, hydrogen may exert its anti-inflammatory and antioxidant effects in the COVID-19.…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19

Wang

Lian

et al. 2021

Front. Med.

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Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has no specific and effective treatment. The pathophysiological process of the COVID-19 is an excessive inflammatory response after an organism infects with a virus. Inflammatory storms play an important role in the development of the COVID-19. A large number of studies have confirmed that hydrogen has a therapeutic effect on many diseases via inhibiting excessive inflammatory cells and factors. Recently, a study led by the Academician Zhong Nanshan in China on the treatment of the patients with the COVID-19 by inhalation of a mixed gas composed of hydrogen and oxygen has attracted widespread international attention and hydrogen therapy has also been included in a new treatment plan for the COVID-19 in China. This study mainly describes the mechanism of occurrence of the COVID-19, summarizes the therapeutic effects and underlying mechanisms of hydrogen on the critical disease, and analyzes the feasibility and potential therapeutic targets of hydrogen for the treatment of the COVID-19.

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Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19

Wang

Lian

et al. 2021

Front. Med.

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“…Additionally, a global scientific discussion has been launched on the ResearchGate platform about the possibility of the use of molecular hydrogen in COVID-19 treatment [ 64 ]. Several articles have been published about the potential benefits of molecular hydrogen therapy for COVID-19 [ 48 , 65 , 66 ], including its ability to combat effects of fatigue [ 67 ]. Although its beneficial effects have been reported in the literature and demonstrated in some clinical trials, a systemic review of the properties and underlying mechanisms of molecular hydrogen is necessary to broaden the utility of its positive effects in treating COVID-19.…”

Section: Importance and Possible Mechanisms Of Molecular Hydrogen In Covid-19 Treatmentmentioning

confidence: 99%

“…Additionally, a global scientific discussion has been launched on the ResearchGate platform about the possibility of the use of molecular hydrogen in COVID-19 treatment[64]. Several articles have been published about the potential benefits of molecular hydrogen therapy for COVID-19[48,65,66], H 2 has a lower solubility in water compared to oxygen and carbon dioxide with 0.8, 1.3, and 34.0 mmol/L at 20 °C, respectively[69]. The hydrogen-saturated water contains 0.78 mM (1.6 mg/L) of hydrogen at 25 °C.…”

mentioning

confidence: 99%

Combating Oxidative Stress and Inflammation in COVID‐19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives

Alwazeer

Liu

et al. 2021

Oxidative Medicine and Cellular Longevity

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COVID-19 is a widespread global pandemic with nearly 185 million confirmed cases and about four million deaths. It is caused by an infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which primarily affects the alveolar type II pneumocytes. The infection induces pathological responses including increased inflammation, oxidative stress, and apoptosis. This situation results in impaired gas exchange, hypoxia, and other sequelae that lead to multisystem organ failure and death. As summarized in this article, many interventions and therapeutics have been proposed and investigated to combat the viral infection-induced inflammation and oxidative stress that contributes to the etiology and pathogenesis of COVID-19. However, these methods have not significantly improved treatment outcomes. This may partly be attributable to their inability at restoring redox and inflammatory homeostasis, for which molecular hydrogen (H2), an emerging novel medical gas, may complement. Herein, we systematically review the antioxidative, anti-inflammatory, and antiapoptotic mechanisms of H2. Its small molecular size and nonpolarity allow H2 to rapidly diffuse through cell membranes and penetrate cellular organelles. H2 has been demonstrated to suppress NF-κB inflammatory signaling and induce the Nrf2/Keap1 antioxidant pathway, as well as to improve mitochondrial function and enhance cellular bioenergetics. Many preclinical and clinical studies have demonstrated the beneficial effects of H2 in varying diseases, including COVID-19. However, the exact mechanisms, primary modes of action, and its true clinical effects remain to be delineated and verified. Accordingly, additional mechanistic and clinical research into this novel medical gas to combat COVID-19 complications is warranted.

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“…Molecular hydrogen is a stable diatomic gas and can be administered either via inhalation or ingestion of water that contains dissolved H2, hydrogen-rich water (HRW) (LeBaron et al, 2019[ 14 ]). Clinical studies have demonstrated its benefits in many different areas including exercise medicine (LeBaron et al, 2019[ 15 ][ 16 ]), cognitive impairments (Nishimaki et al, 2018[ 20 ]), stroke (Ono et al, 2017[ 21 ]), cancer (Akagi and Baba, 2019[ 1 ]), metabolic syndrome (LeBaron et al, 2020[ 17 ]), and recently in patients with COVID-19 (Guan et al, 2020[ 7 ]; Russell et al, 2020[ 23 ]).…”

Section: Introductionmentioning

confidence: 99%

Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice

LeBaron

Asgharzadeh

Khazaei

et al. 2021

EXCLI Journal; 20:Doc1106; ISSN 1611-2156

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An Overview of SARS-CoV-2 (COVID-19) Infection and the Importance of Molecular Hydrogen as an Adjunctive Therapy

Cited by 15 publications

References 0 publications

Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19

Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19

Combating Oxidative Stress and Inflammation in COVID‐19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives

Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice

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