An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study

Nwabuko, Ogbonna Collins; Onwuchekwa, Uwa; Iheji, Okechukwu

doi:10.11604/pamj.2022.41.161.27117

Cited by 12 publications

(10 citation statements)

References 20 publications

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“… 10 , 11 In Africa, approximately 150,000 to 300,000 children die of sickle cell anemia annually counting for 5% to 10% of child mortality. 12 , 13 This situation in African regions indicates that current national policies and plans are inadequate, and appropriate facilities and trained personnel are scarce. 14 In Uganda, the prevalence of SCD and SCT is distributed depending on the district with a total prevalence of 0.7% and 13.3% of SCD and SCT, respectively.…”

Section: Introductionmentioning

confidence: 99%

Sickle cell trait screening in students in a Ugandan university: a cross-sectional study

2022

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Objective To determine the uptake, knowledge level and attitude towards sickle cell trait screening in students aged 18 to 35 years in a Ugandan university. Methods This was a university-based, cross-sectional study of students aged 18 to 35 years who were students at the Busitema University Faculty of Health Sciences. We used a simple random sampling technique to recruit participants. We conducted multivariable logistic regression to establish the association between factors such as age, year of study, marital status and uptake of sickle cell trait screening (SCTS) services. Results A total of 315 students participated in the study. The uptake rate of SCTS was 24.4%. The knowledge level regarding sickle cell disease/SCTS was 93.7%, and 73.3% of respondents had a positive attitude towards SCTS, with a mean score of 23.32 ± 5.84. A multivariate analysis showed that those aged 25 to 29 years were 7.8 times more likely to have SCTS, while married respondents were 1.3 times more likely to be screened. Conclusion The uptake of SCTS services was low relative to the total number of participants recruited in this study. Therefore, the uptake of SCTS needs to be encouraged in students at universities.

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Section: Introductionmentioning

confidence: 99%

Sickle cell trait screening in students in a Ugandan university: a cross-sectional study

2022

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“…Though it might be di cult to blame the gene for this difference, similar ndings were reported in Brazil, but differ from the Indian study. This gender difference might re ect the frequency of reports to hospital, and only community-based study can give a clear image regarding gender differences (44)(45)(46). The prevalence of enuresis is high among Sudanese children, many factors contribute to the prevalence of enuresis among children like toilet training, developmental delay, socioeconomic status which are common to all children including sticklers due to the involvement of the kidneys due to the pathogenesis of sickle cell disease.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Current Clinical Research Spectrum of Sickle Cell Anemia to Approach New Innovative Developmental Techniques for Enhancing Sudanese Health Systems

Salih

Saad

Eldouch³

et al. 2022

Preprint

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Background Sickle cell Anemia and/or Disease (SCA/SCD) is an autosomal recessive disease leading to abnormal hemoglobin with global prevalence in general and tribal burden in sub-Saharan Africa particularly. Methods Recent patients’ assessments were done using routine diagnostic protocols for SCA monitoring and manifestations. Insight of the physicians towards innovative techniques at the molecular level were done to enhance medical performance of the disease investigations. The online questionnaire showed the response and acceptance levels of the physicians to introduced innovative techniques in integration with current clinical and laboratory’s spectrums. Data interpretation and statistical analysis were done using IBM-SPSS ver 25 and MS. Excel 2019. Results Clinical manifestation showed painful crises, (Hand and food syndrome) and enuresis were observed in more than half of the patients, while stroke observed only in 5.5%. A strong association was observed in males regarding Hb vs RBC and MCV vs HbA2.However. females show an association between MCV vs HbA2 only. SCA current spectrum include CBC, BF and Solubility Sickling Test showed significant results in Hemoglobin P < 0.05 and Strong association was observed between Hb vs RBC, MCV vs HbA2 for males and MCV vs HbA2 for female only. Polymerase Chain Reaction (PCR) was introduced to detect inherited polymorphic traits in infants and parents beside the flow cytometry gave a detailed informatic image for the up normal blood cells shape and amounts comparing with normal ones. The high response of the online questionnaire (100%) showed the attitude of doctors and related staff accepting innovative techniques for enhancing current health system. Conclusions Although the current clinical and laboratory diagnostic protocols are effective for diagnosing SCA, the follow-up and treatment but the approach of innovative techniques is highly demanded for detecting un-seen symptoms and hidden polymorphic traits, beside monitoring all patients with including other family members.

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“…Sickle Cell Disease is an inherited disorder of hemoglobin caused by an abnormal hemoglobin molecule, hemoglobin S (HbS), which results in the sickling of red blood cells. HbSS is the most common and severe type of SCD found in Nigeria, including SS, SC, and HbSβthalassemia [1,2]. Its spectrum of clinical symptoms is classified into vaso-occlusive, hemolytic, acute chest syndrome, and aplastic crises.…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic Status as a Determinant of Delayed Diagnosis of Sickle Cell Disease - A Case Report of Newly Diagnosed Sickle Cell Disease in a 52-Year-Old Woman

Egbunu¹,

Elendu²,

Amosu

et al. 2023

AIR

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A look into socioeconomic status (SES) associations with delayed diagnosis of sickle cell disease (SCD) is necessary to improve societal norms, governmental health policies, and strategies. A person's social standing in a society is generally governed by the combination of his education, profession, and income, which is regarded as his SES. Considerable evidence establishes the likelihood of individuals from low SES suffering from the disease, cognitive problems, and increased mortality (Lubeck et al., 2019, National Research, 2004). Sickle cell disease (SCD) is one of the most common severe genetic hemoglobinopathies recognized by the World Health Organization as a global public health problem. Socioeconomic status (SES) is an individual's social or economic standing and measures an individual's or family's financial position or rank in a social group. Current guidelines and management algorithms of SCD do not factor in the effect of SES on patients with SCD. There needs to be more literature regarding the role of SES and its impact on clinical outcomes and characteristics of SCD. Studies have shown that lower SES is linked to disproportionate access to health care in many diseases, and of all the factors that measure SES, income was the most indicative.

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An overview of sickle cell disease from the socio-demographic triangle - a Nigerian single-institution retrospective study

Cited by 12 publications

References 20 publications

Sickle cell trait screening in students in a Ugandan university: a cross-sectional study

Sickle cell trait screening in students in a Ugandan university: a cross-sectional study

Evaluation of Current Clinical Research Spectrum of Sickle Cell Anemia to Approach New Innovative Developmental Techniques for Enhancing Sudanese Health Systems

Socioeconomic Status as a Determinant of Delayed Diagnosis of Sickle Cell Disease - A Case Report of Newly Diagnosed Sickle Cell Disease in a 52-Year-Old Woman

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