An overview of solvents in resin–dentin bonding

Cytotoxicity test of 4-methacryloxyethyl trimellitic anhydride–based dentine bonding material using acetone solution in dental pulp fibroblast

“…It also denotes that the material is neither toxic nor dangerous if applied to living tissues. [13] Considering the close contact with dentine and vital pulp tissue, also in case of accidental contact with the other tissue in the oral cavity, a cytotoxicity test of the dentin adhesive material is necessary. However, cytotoxicity assessment of a material is mostly performed in cell culture due to ethical reasons.…”

“…Acetone is known to be a volatile solvent with weak hydrogen-binding capacity resulting in the poor performance of the antioxidant mechanism involved in free radical binding. [13] According to Bakir et al, [5] 4-META monomers induce adverse effects including cell death in tissues. The clinical procedure described earlier supports the aim of this study in determining the minimum toxic concentration of 4-META-based dentine bonding material in acetone solution, which can cause the death of 50% of dental pulp fibroblasts.…”

“…In addition to their monomer composition, dentin bonding materials also contain solvent, which plays an important role in diffusing the monomers between collagen fibrils. [13] As a solvent, acetone is commonly used in dentin bonding material due to its ability in attracting the moisture to prevent the breakdown of collagen fibrils before evaporating and being replaced by 4-META, thus resulting in a good binding between monomer and collagen fibrils. [9,13] A study by Prasetyo et al [14] confirmed that 4-META bonding agent featuring acetone solvent shows superior chemical bond strength compared to that containing ethanol solvent.…”

Influence of polar solvents on permeability, stiffness and collagen dissociation of demineralized dentin

“…Solvents are essential components of dental adhesive resins to solvate the resin monomer mixtures, decrease viscosity and increase molecular mobility [6]. Solvated adhesive application to dentin enhances the penetration of resin monomer into inter-fibrillar spaces and simultaneously facilitates the displacement of water from dentin [6,7]. Furthermore, some solvents contribute to the inhibition of the hostderived endogenous enzymatic activity in dentin [8].…”

Optimization of the etch-and-rinse technique: New perspectives to improve resin–dentin bonding and hybrid layer integrity by reducing residual water using dimethyl sulfoxide pretreatments

“…DMSO is perhaps the best currently known penetration enhancer for medical purposes [24] with the ability to dissociate the highly crosslinked collagen into a sparser network of apparent fibrils [25] concentration dependently. In addition, dissociation of water self-associative tendency by DMSO [26] improves wettability of demineralized dentin [27,28], monomer diffusion into the collagen matrix [8] and concomitantly re-expands collapsed collagen to a fairly modest level [28].…”