An Overview of the CCAAT-Box Binding Factor in Filamentous Fungi: Assembly, Nuclear Translocation, and Transcriptional Enhancement

Kato, Masashi

doi:10.1271/bbb.69.663

Cited by 56 publications

(38 citation statements)

References 87 publications

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“…The CCAAT/enhancer element is a common cis-element in the promoters of many genes (Edwards et al, 1998;Kato, 2005;McNabb et al, 1995;Yazawa & Kamada, 2007). Several studies have demonstrated that the CCAAT/enhancer binding protein sites in the human immunodeficiency virus type 1 (HIV-1) LTR are crucial for HIV-1 replication in monocyte/macrophages and for the ability of IFN-b to inhibit ongoing active HIV replication in these cells (Henderson & Calame, 1997;Henderson et al, 1995Henderson et al, , 1996Ravimohan et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

An avian leukosis virus subgroup J isolate with a Rous sarcoma virus-like 5′-LTR shows enhanced replication capability

Gao

Guan

Liu

et al. 2015

Journal of General Virology

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Section: Discussionmentioning

confidence: 99%

An avian leukosis virus subgroup J isolate with a Rous sarcoma virus-like 5′-LTR shows enhanced replication capability

Gao

Guan

Liu

et al. 2015

Journal of General Virology

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“…Currently, the various NF-Y subunits of rice (and other species, although less fully adopted) are often referred to by the yeast HAP2/3/5 nomenclature (homologs of NF-YA, NF-YB, and NF-YC, respectively; Miyoshi et al, 2003;Yazawa and Kamada, 2007;Thirumurugan et al, 2008;Xie et al, 2008;Yu et al, 2011). This has created confusion and difficulty following the literature in three principal ways: (1) To the best of our knowledge, plants are devoid of homologs of HAP4, which is required for transcriptional activation in fungi (McNabb and Pinto, 2005;Kato, 2005), and they form a mammalian-like trimer.…”

Section: Classification Nf-ys and Hapsmentioning

confidence: 99%

The Promiscuous Life of Plant NUCLEAR FACTOR Y Transcription Factors

et al. 2012

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The CCAAT box is one of the most common cis-elements present in eukaryotic promoters and is bound by the transcription factor NUCLEAR FACTOR Y (NF-Y). NF-Y is composed of three subunits, NF-YA, NF-YB, and NF-YC. Unlike animals and fungi, plants have significantly expanded the number of genes encoding NF-Y subunits. We provide a comprehensive classification of NF-Y genes, with a separation of closely related, but distinct, histone fold domain proteins. We additionally review recent experiments that have placed NF-Y at the center of many developmental stress-responsive processes in the plant lineage.

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“…This conclusion is emphasized by the observation that reducing CO levels by half in heterozygous plants delays flowering . The HAP complex of mammals forms by the HAP3 subunit interacting with the HAP5 subunit to form a heterodimer, which then binds the third subunit HAP2 (Kato, 2005). If a complex involving CO must also form in a defined series of steps, then overexpression of At HAP3a could alter the stoichiometry of components and recruit CO or one of the other components into unproductive complexes.…”

Section: Significance Of the Region Of Homology Between Hap2 And Cctmentioning

confidence: 99%

CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering ofArabidopsis

et al. 2006

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The CCT (for CONSTANS, CONSTANS-LIKE, TOC1) domain is found in 45 Arabidopsis thaliana proteins involved in processes such as photoperiodic flowering, light signaling, and regulation of circadian rhythms. We show that this domain exhibits similarities to yeast HEME ACTIVATOR PROTEIN2 (HAP2), which is a subunit of the HAP2/HAP3/HAP5 trimeric complex that binds to CCAAT boxes in eukaryotic promoters. Moreover, we demonstrate that CONSTANS (CO), which promotes Arabidopsis flowering, interacts with At HAP3 and At HAP5 in yeast, in vitro, and in planta. Mutations in CO that delay flowering affect residues highly conserved between CCT and the DNA binding domain of HAP2. Taken together, these data suggest that CO might replace At HAP2 in the HAP complex to form a trimeric CO/At HAP3/At HAP5 complex. Flowering was delayed by overexpression of At HAP2 or At HAP3 throughout the plant or in phloem companion cells, where CO is expressed. This phenotype was correlated with reduced abundance of FLOWERING LOCUS T (FT) mRNA and no change in CO mRNA levels. At HAP2 or At HAP3 overexpression may therefore impair formation of a CO/At HAP3/At HAP5 complex leading to reduced expression of FT. During plant evolution, the number of genes encoding HAP proteins was greatly amplified, and these proteins may have acquired novel functions, such as mediating the effect of CCT domain proteins on gene expression.

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An Overview of the CCAAT-Box Binding Factor in Filamentous Fungi: Assembly, Nuclear Translocation, and Transcriptional Enhancement

Cited by 56 publications

References 87 publications

An avian leukosis virus subgroup J isolate with a Rous sarcoma virus-like 5′-LTR shows enhanced replication capability

An avian leukosis virus subgroup J isolate with a Rous sarcoma virus-like 5′-LTR shows enhanced replication capability

The Promiscuous Life of Plant NUCLEAR FACTOR Y Transcription Factors

CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering ofArabidopsis

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