An overview of the current state of phage therapy for the treatment of biofilm-related infections

Pires, Diana Priscila Penso; Meneses, Luciana; Brandão, Ana Catarina; Azeredo, Joana

doi:10.1016/j.coviro.2022.101209

Cited by 31 publications

(14 citation statements)

References 52 publications

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“…After aggregating into clusters via adhesins and cytoderm proteins, the bacteria change from a planktonic state to a bacterial thin film. A biofilm refers to an aggregated mixture of bacteria, biofilm matrix, and extracellular polymers. , Biofilm production is the most important process in IBD formation because it can hinder the infiltration of antimicrobials and immune cells, helping pathogenic bacteria escape attacks from antibiotics and the host immune system. Biofilms also cause the development of drug-resistant bacteria.…”

Section: Discussionmentioning

confidence: 99%

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Yao

et al. 2022

ACS Biomater. Sci. Eng.

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Infected bone defects (IBDs) cause significant economic and psychological burdens, posing a huge challenge to clinical orthopedic surgeons. Traditional approaches for managing IBDs possess inevitable shortcomings; therefore, it is necessary to develop new functionalized scaffolds. Tantalum (Ta) has been widely used in load-bearing orthopedic implants due to its good biocompatibility and corrosion resistance. However, undecorated Ta could only structurally repair common bone defects, which failed to meet the clinical needs of bacteriostasis for IBDs. Researchers have made great efforts to functionalize Ta scaffolds to enhance their antibacterial activity through various methods, including surface coating, alloying, and micro-and nanostructure modifications. Additionally, several studies have successfully utilized Ta to modify orthopedic scaffolds for enhanced antibacterial function. These studies remarkably extended the application range of Ta. Therefore, this review systematically outlines the advances in the fundamental and clinical application of Ta in the treatment of IBDs, focusing on the antibacterial properties of Ta, its functionalization for bacteriostasis, and its applications in the modification of orthopedic scaffolds. This study provides researchers with an overview of the application of Ta in the treatment of IBDs.

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Section: Discussionmentioning

confidence: 99%

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Yao

et al. 2022

ACS Biomater. Sci. Eng.

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“…Thus, phages can fail to resolve an infection caused by a pathogen even if those phages appear to be powerfully active in vitro. Phage therapies, nonetheless, may be more promising than antibiotics in some cases in the treatment of biofilms [ 54 , 106 , 242 , 243 ].…”

Section: Continuing Challenges For Phage Therapymentioning

confidence: 99%

Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

et al. 2023

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Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing numbers of clinical case studies being published. This renewed enthusiasm is due in large part to phage therapy holding promise for providing safe and effective cures for bacterial infections that traditional antibiotics acting alone have been unable to clear. This Essay introduces basic phage biology, provides an outline of the long history of phage therapy, highlights some advantages of using phages as antibacterial agents, and provides an overview of recent phage therapy clinical successes. Although phage therapy has clear clinical potential, it faces biological, regulatory, and economic challenges to its further implementation and more mainstream acceptance.

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“…Despite being recognized as significant contributors to the onset of various human diseases, our understanding of biofilm-associated infections and effective treatment strategies is in early stages. − Conventional treatment methods often struggle to completely eradicate biofilms. Several treatment strategies have been explored apart from antibiotics to combat and eliminate biofilms, including the use of enzymes or antimicrobial peptides, − quorum sensing inhibitors, − and phage therapy. − …”

Section: Introductionmentioning

confidence: 99%

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

Jothi Nayaki,

Roja,

Ravindhiran

et al. 2024

ACS Infect. Dis.

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The global surge in bacterial infections, compounded by the alarming escalation of drug-resistant strains, has evolved into a critical public health crisis. Among the challenges posed, biofilms stand out due to their formidable resistance to conventional antibiotics. This review delves into the burgeoning potential of pillar[n]arenes, distinctive macrocyclic host molecules, as promising anti-biofilm agents. The review is structured into two main sections, each dedicated to exploring distinct facets of pillar[n]arene applications. The first section scrutinizes functionalized pillar[n]arenes with a particular emphasis on cationic derivatives. This analysis reveals their significant efficacy in inhibiting biofilm formation, underscoring the pivotal role of specific chemical attributes in combating microbial communities. The second section of the review shifts its focus to inclusion complexes, elucidating how pillar[n]arenes serve as encapsulation platforms for antibiotics. This encapsulation enhances the stability of antibiotics and enables a controlled release, thereby amplifying their antibacterial activity. The examination of inclusion complexes provides valuable insights into the potential synergy between pillar[n]arenes and traditional antibiotics, offering a novel avenue for overcoming biofilm resistance. This comprehensive review highlights the escalating global threat of bacterial infections and the urgent need for innovative strategies to counteract drugresistant biofilms. The unique properties of pillar[n]arenes, both as functionalized molecules and as inclusion complex hosts, position them as promising candidates in the quest for effective anti-biofilm agents. The exploration of their distinct mechanisms opens new avenues for research and development in the ongoing battle against bacterial infections and biofilm-related health challenges.

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An overview of the current state of phage therapy for the treatment of biofilm-related infections

Cited by 31 publications

References 52 publications

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

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