2015
DOI: 10.5507/bp.2013.092
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An overview of the risk factors associated with multiple oral premalignant lesions with a case report of extensive field cancerization in a female patient

Abstract: Background. Field cancerization is a well-known and well-documented process of malignant transformation first coined by Slaughter et al. in 1953. Tobacco chewing was associated with the greatest increase in the risk of multiple oral premalignant lesions and may be the major source of field cancerization of the oral cavity in the Indian population. The field cancerization will probably help clinicians in complementing evaluation of pathologic biopsy specimens. Material and Methods. We present a case report of f… Show more

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Cited by 3 publications
(3 citation statements)
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“…It is believed that the presence of dysplasia in the oral epithelium signifies a likely progression to cancer. The consensus is that the more severe the degree of dysplasia, the greater the likelihood of progression to malignancy [14], [15], [16]. Therefore, because the majority of the patients in this study have no history of smoking, alcohol, or chewing habits, a search for other causes such as genetic, exposure to ionizing radiation, or viral infection is recommended if they showed significant changes on mirror image biopsy.…”
Section: Discussionmentioning
confidence: 99%
“…It is believed that the presence of dysplasia in the oral epithelium signifies a likely progression to cancer. The consensus is that the more severe the degree of dysplasia, the greater the likelihood of progression to malignancy [14], [15], [16]. Therefore, because the majority of the patients in this study have no history of smoking, alcohol, or chewing habits, a search for other causes such as genetic, exposure to ionizing radiation, or viral infection is recommended if they showed significant changes on mirror image biopsy.…”
Section: Discussionmentioning
confidence: 99%
“…About half GDPs neglected tongue examinations. This is a worrisome finding, as these two areas are at high risk for the development of OPMD and could potentially develop into carcinoma (Mortazavi et al, 2014 ; Sreedhar et al, 2015 ; Warnakulasuriya et al, 2007 ). Hence, improvements are needed in the dental curriculum to equip students to undertake a proper clinical assessment of the oral mucosa and to recognize mucosal abnormalities, including OPMD and cancer.…”
Section: Discussionmentioning
confidence: 99%
“…As majority of oral cancer is caused by high-risk habits such as smoking, chewing of tobacco/areca nut and consumption of alcohol, the entire oral cavity mucosa can harbor dysplastic mucosa by the process of field cancerization [30][31][32]. The clinical significance of dysplastic lesions in the surgical margin is controversial, demonstrating both positive [33] and no correlation [34] with local recurrence.…”
Section: Discussionmentioning
confidence: 99%