An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing

Abstract

The global burden of disease associated with wounds is an increasingly significant public health concern. Current treatments are often expensive, time‐consuming and limited in their efficacy in chronic wounds. The challenge of overcoming current barriers associated with wound care requires innovative management techniques. Regenerative medicine is an emerging field of research that focuses on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function. This article provides an overview of the pathophysiology of wound healing and reviews the latest evidence on the application of the principal components of regenerative medicine (growth factors, stem cell transplantation, biomaterials and tissue engineering) as therapeutic targets. Improved knowledge and understanding of the pathophysiology of wound healing has pointed to new therapeutic targets. Regenerative medicine has the potential to underpin the design of specific target therapies in acute and chronic wound healing. This personalised approach could eventually reduce the burden of disease associated with wound healing. Further evidence is required in the form of large animal studies and clinical trials to assess long‐term efficacy and safety of these new treatments.

Effects of Different Protocols of Low-Level Laser Therapy on Collagen Deposition in Wound Healing

“…The proper care of chronic wounds has become a challenge in public health, often including advanced therapies, such as new drugs and low-level laser therapy (LLLT) (2). Because the pathophysiology of wound healing involves a wide range of biochemical and molecular mechanisms, therapeutic strategies are challenging (3).…”

Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain

“…During epithelialization, Fibro. migrate into the wounded area to reorganize extracellular matrix, deposit collagen and causing wound contraction [1][2][3]8,9]. Thus, signal molecules that regulate the migration of Kera., Fibro., and endothelial cells may alter the rate of wound healing.…”

Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review

“…As a critical treatment medium, polymer‐based functional materials are widely applied to treat various stages of CVI because of their unique physical, mechanical, chemical, and biological properties (Cornish, ; Pang, Ibrahim, Bulstrode, & Ferretti, ). These materials are mainly fabric‐based compression devices (e.g., compression stockings (Hobson et al, ), compression bandages (Wiklander, Andersson, & Källman, ), and intermittent pneumatic pump) used to treat CVI with C 1 – C 6 symptoms, and functional wound dressings (e.g., scaffolds (Dickinson & Gerecht, ), pads (Brown, ), and sutures (Masood et al, )) to facilitate primary treatment of leg ulceration (i.e., classes C 5 – C 6 ) (Figure ).…”

“…As a critical treatment medium, polymer-based functional materials are widely applied to treat various stages of CVI because of their unique physical, mechanical, chemical, and biological properties (Cornish, 2017;Pang, Ibrahim, Bulstrode, & Ferretti, 2017).…”