An overview of the toxic effect of potential human carcinogen Microcystin-LR on testis

Lone, Yaqoob; Koiri, Raj Kumar; Bhide, Mangla

doi:10.1016/j.toxrep.2015.01.008

Cited by 123 publications

(64 citation statements)

References 47 publications

(71 reference statements)

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“…In addition, the study of Chen and Xie [40] has raised questions and great concerns about the probable reproductive toxicity of MCs. Recent studies have verified that MCs accumulate in testis [32,50,51] and ovary [44,52], and exert toxic effects on the reproductive system [53,54].…”

Section: Introductionmentioning

confidence: 99%

A review of reproductive toxicity of microcystins

Chen

Zhang

et al. 2016

Journal of Hazardous Materials

310

126

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Section: Introductionmentioning

confidence: 99%

A review of reproductive toxicity of microcystins

Chen

Zhang

et al. 2016

Journal of Hazardous Materials

310

126

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“…microcystin-LR (MC-LR) is the most toxic microcystin amongst approximately 100 congeners of the known microcystins [3]. The heptapeptide is reported to be hepatotoxic [4] and a potential human carcinogen [5]. Therefore, a guideline of 1 µg·L −1 has been set for this toxin by the World Health Organization (WHO) for drinking water quality [6].…”

Section: Introductionmentioning

confidence: 99%

Impacts of Hydrogen Peroxide and Copper Sulfate on the Control of Microcystis aeruginosa and MC-LR and the Inhibition of MC-LR Degrading Bacterium Bacillus sp.

Kansole

Lin

2017

Water

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Abstract:Laboratory batch experiments were carried out to evaluate the impacts of H 2 O 2 and copper sulfate on M. aeruginosa PCC7820, microcystin-LR (MC-LR) and its degrading bacteria Bacillus sp., previously isolated from Hulupi Lake in Taiwan. The study shows that 3 mg·L −1 hydrogen peroxide removed only 9% M. aeruginosa within seven days of exposure, from an initial cell concentration of 2 × 10 6 cells/mL. With copper sulfate, a concentration of 2 mg·L −1 removed 99% M. aeruginosa cells, but showed negligible efficacy in removing 0.05 mg·L −1 MC-LR. At a higher dosage, 20 mg·L −1 H 2 O 2 led to 40% and 95% removal, respectively for MC-LR and M. aeruginosa cells. Copper sulfate and H 2 O 2 were both lethal to Bacillus sp. population, with mortality rate constants of k = 0.04 h −1 and 0.03 h −1 under 1 mg·L −1 copper sulfate and 5 mg·L −1 H 2 O 2 , respectively. H 2 O 2 is competitive in terms of cost, with a capability of degrading organic compounds with the assistance of ultraviolet (UV) light, and it may be considered as an alternative algaecide to copper sulfate in reservoirs for algae growth control.

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“…Studies on the toxicity to the gonad, induced by MC‐LR, have found that MC‐LR can accumulate in the reproductive systems of mice, rats, amphibians, and fishes . Furthermore, previous studies have shown that MC‐LR can increase reactive oxygen species (ROS) and decrease the expression of more than 100 kinds of microRNAs in spermatogonia .…”

Section: Introductionmentioning

confidence: 99%

p53‐Dependent pathway and the opening of mPTP mediate the apoptosis of co‐cultured Sertoli‐germ cells induced by microcystin‐LR

Liu

Huang

et al. 2019

Environmental Toxicology

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Microcystin‐LR (MC‐LR), a potent endotoxin, can induce reproductive toxicity. In order to investigate the role and mechanisms of apoptosis (p53‐dependent and mitochondrial pathways) of germ cells induced by MC‐LR, the co‐cultured primary Sertoli‐germ cells from Sprague‐Dawley rats were used for the experiments. Expression levels of proteins, genes, and mitochondrial membrane potential (MMP) were obtained after exposing co‐cultured Sertoli‐germ cells to MC‐LR with or without the addition of the p53 inhibitor, pifithrin‐α (PFT‐α), and MMP inhibitor, cyclosporin A (CsA). Results indicated that MC‐LR could activate p53‐dependent pathway‐associated proteins in Sertoli‐germ cells, leading to a decrease in MMP (indicating the opening of mitochondrial permeability transition pore [mPTP] and the release of Cytochrome‐c [Cyt‐c]) from the mitochondria into the cytoplasm and eventually the induction of apoptosis. PFT‐α inhibited the expression ofp53, ameliorated the MMP of the co‐cultured Sertoli‐germ cells, and prevented the release of Cyt‐c from the mitochondria into the cytoplasm, which reduces the occurrence of apoptosis. Similarly, the decreased release of Cyt‐c from the mitochondria into the cytoplasm and the declined level of apoptosis in Sertoli‐germ cells induced by MC‐LR were observed after the addition of CsA. These results indicated that the apoptosis of the co‐cultured Sertoli‐germ cells induced by MC‐LR was mediated by the p53‐dependent pathway, with the involvement of the opening of mPTP.

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An overview of the toxic effect of potential human carcinogen Microcystin-LR on testis

Abstract: Graphical abstract

Cited by 123 publications

References 47 publications

A review of reproductive toxicity of microcystins

A review of reproductive toxicity of microcystins

Impacts of Hydrogen Peroxide and Copper Sulfate on the Control of Microcystis aeruginosa and MC-LR and the Inhibition of MC-LR Degrading Bacterium Bacillus sp.

p53‐Dependent pathway and the opening of mPTP mediate the apoptosis of co‐cultured Sertoli‐germ cells induced by microcystin‐LR

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