An Overview on Natural Product from Endophytic Actinomycetes

Rajivgandhi, Govindan; Vimala, R.T.V.; Ramachandran, Govindan; Kanisha, C. Chenthis; Manoharan, Natesan; Li, Wenjun

doi:10.1007/978-981-16-6132-7_6

Cited by 3 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Actinomycetes isolated from mangroves have wide application in industries as they can be exploited as producers of antibiotics, enzymes, enzyme inhibitors, antitumour agents etc (Rajivgandhi et al 2024). Various antibiotic producing actinomycetes have been isolated from mangrove ecosystems.…”

Section: Actinomycetesmentioning

confidence: 99%

Unique adaptations and bioresources of mangrove ecosystems

Ramesh,

Sajan,

Namitha

et al. 2024

EEB

View full text Add to dashboard Cite

Mangroves are unique ecosystems. As they are present in a transition zone, they harbour a variety of organisms, which include microorganisms, aquatic as well as terrestrial organisms. Being present in an ever-changing and adverse environment, mangroves have developed several adaptations that make them unique. These unique features have been exploited for the isolation of various useful compounds from mangroves. The organisms associated with the mangrove ecosystem will also be well equipped to survive such extreme conditions. Microorganisms such as bacteria, fungi, actinomycetes, algae etc, survive in this changing environment, and they might be producing certain metabolites as a part of their survival mechanism, which can be exploited for the production of various compounds that are useful to mankind. Mangrove microorganisms can be used as an important source of food, medicines, enzymes, antimicrobials etc.

show abstract

Section: Actinomycetesmentioning

confidence: 99%

Unique adaptations and bioresources of mangrove ecosystems

Ramesh,

Sajan,

Namitha

et al. 2024

EEB

View full text Add to dashboard Cite

show abstract

“…Endophytic microorganisms, especially actinomycetes [ 47 , 48 ] and fungi [ 49 ], possess a great variety of biologically active metabolites. Endophytic bacteria are used not only in medicine and veterinary medicine, but also as biofertilizers and biocontrol agents in agriculture [ 50 , 51 ].…”

Section: Microbiologymentioning

confidence: 99%

“…In 2022, the Lewis group isolated a new potent and selective antibiotic, evybactin (Figure 5), active against Mycobacterium tuberculosis, from another nematode symbiont strain, Photorhabdus noenieputensis DSM 25462 [46]. Endophytic microorganisms, especially actinomycetes [47,48] and fungi [49], possess a great variety of biologically active metabolites. Endophytic bacteria are used not only in medicine and veterinary medicine, but also as biofertilizers and biocontrol agents in agriculture [50,51].…”

Section: Exploring New Habitatsmentioning

confidence: 99%

Modern Trends in Natural Antibiotic Discovery

Baranova

Alferova

Korshun

et al. 2023

Life

View full text Add to dashboard Cite

Natural scaffolds remain an important basis for drug development. Therefore, approaches to natural bioactive compound discovery attract significant attention. In this account, we summarize modern and emerging trends in the screening and identification of natural antibiotics. The methods are divided into three large groups: approaches based on microbiology, chemistry, and molecular biology. The scientific potential of the methods is illustrated with the most prominent and recent results.

show abstract

“…5,6 Nocardiopsis species have also been identified as endophytes or surface microflora on specific plants and their rhizospheres. 5,7 This interaction has resulted in the production of notable enzymes, such as α-amylase, and the synthesis of potent antimicrobial agents with noteworthy efficacy against plant pathogens. 8 For instance, the chemical investigation of Nocardiopsis sp.…”

mentioning

confidence: 99%

“…For several decades, marine microorganism-derived natural products have served as one of the most significant sources of clinical drugs. , For example, numerous studies have demonstrated the ability of Nocardiopsis , a genus of actinomycete, to produce new bioactive natural compounds. , Members of the genus Nocardiopsis are halophilic bacteria that flourish in various high-salinity habitats, including salt lakes, brine ponds, and salt pans. , Nocardiopsis species have also been identified as endophytes or surface microflora on specific plants and their rhizospheres. , This interaction has resulted in the production of notable enzymes, such as α-amylase, and the synthesis of potent antimicrobial agents with noteworthy efficacy against plant pathogens . For instance, the chemical investigation of Nocardiopsis sp.…”

mentioning

confidence: 99%

Genomic and Metabolomic Analyses of Nocardiopsis maritima YSL2 as the Mycorrhizosphere Bacterium of Suaeda maritima (L.) Dumort

Lee,

Um,

Kim

et al. 2024

J. Nat. Prod.

View full text Add to dashboard Cite

Nine bacteria were isolated from the episphere of Suaeda maritima (L.) Dumort. Among them, the bacterial strain YSL2 displayed the highest antimicrobial activity on agar plates and exhibited significant novelty compared with other bacteria based on 16S rRNA analysis. Consequently, Nocardiopsis maritima YSL2 T was subjected to phenotypic characterization and whole-genome sequencing. Phylogenetic analysis revealed its close association with Nocardiopsis aegyptia SNG49 T . Furthermore, genomic analysis of strain YSL2 T revealed the presence of various gene clusters, indicating its potential for producing antimicrobial secondary metabolites. Upon cultivation on a large scale, maritiamides A and B (1 and 2) were isolated and characterized as cyclic hexapeptides based on nuclear magnetic resonance, ultraviolet, infrared, and mass spectrometric data. The absolute configurations of the amino acid residues in the maritiamides were determined through chiral derivatization, utilizing FDAA and GITC. Maritiamides 1 and 2 exhibited promising antibacterial activities against Staphylococcus epidermidis and weakly inhibited the growth of Escherichia coli and Pseudomonas f luorescens.

show abstract

An Overview on Natural Product from Endophytic Actinomycetes

Cited by 3 publications

References 38 publications

Unique adaptations and bioresources of mangrove ecosystems

Unique adaptations and bioresources of mangrove ecosystems

Modern Trends in Natural Antibiotic Discovery

Genomic and Metabolomic Analyses of Nocardiopsis maritima YSL2 as the Mycorrhizosphere Bacterium of Suaeda maritima (L.) Dumort

Contact Info

Product

Resources

About