An ultralong hydroxyapatite nanowire aerogel for rapid hemostasis and wound healing

Yi, Zheng; Ma, Wanhong; Yang, Zhibo; Zhang, Hongjian; Ma, Jingge; Li, Tian; Niu, Huicong; Zhou, Yanling; Yao, Qingqiang; Chang, Jiang; Zhu, Yufang; Wu, Chengtie

doi:10.1016/j.cej.2021.132912

Cited by 53 publications

(38 citation statements)

References 53 publications

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“…Blood coagulation was evaluated by the blood-clotting test and reflected by the blood-clotting index (BCI), according to a previously reported method [ 53 , 54 ].…”

Section: Methodsmentioning

confidence: 99%

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Baron

Duceac

Morariu³

et al. 2022

Gels

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The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management.

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“…Blood coagulation was evaluated by the blood-clotting test and reflected by the blood-clotting index (BCI), according to a previously reported method [ 53 , 54 ].…”

Section: Methodsmentioning

confidence: 99%

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Baron

Duceac

Morariu³

et al. 2022

Gels

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“…As a promising candidate for hemostatic sealant, hydrophilic surface of the hydrogel bioadhesive was helpful to absorbing interfacial water and accumulating blood cells or platelets as it came into contact with blood, thereby enhancing blood clotting ability, accelerating formation of thrombus, as well as promoting wound healing. [20] Desirable mechanical properties are essential for the hemostatic hydrogel materials because sufficient mechanical strength is beneficial to improve wound sealing, maintain structural integrity during surgical operation, and withstand pressure exerted by the surrounding tissues. Tensile properties of the hydrogels were measured and the corresponding stress-strain curves were illustrated in Figures S4 and S5 in the Supporting Information.…”

Section: Physicochemical Properties Of Hydrogelsmentioning

confidence: 99%

Mussel‐ and Barnacle Cement Proteins‐Inspired Dual‐Bionic Bioadhesive with Repeatable Wet‐Tissue Adhesion, Multimodal Self‐Healing, and Antibacterial Capability for Nonpressing Hemostasis and Promoted Wound Healing

Pan

et al. 2022

Adv Funct Materials

151

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Massive bleeding and wound infection are the major problems often observed during severe trauma, and achieving rapid hemostasis in cases of high‐dose bleeding in arteries and viscera remains an acute clinical demand. Herein, a mussel‐ and barnacle cement proteins‐inspired dual‐bionic hydrogel is first proposed. Benefiting from abundant phenolic hydroxyl groups, a tough dissipative matrix, removal of interfacial water, as well as dynamic redox balance of phenol‐quinone, the multinetwork hydrogel achieves repeatable robust wet‐tissue adhesiveness (151.40 ± 1.50 kPa), a fast multimodal self‐healing ability, and excellent antibacterial property against both Gram‐positive/negative bacteria. For rabbit/pig models of cardiac penetration holes and femoral artery injuries, the dual‐bionic bioadhesive shows better hemostatic efficiency than commercial gauze due to the synergistic effect of strong wound sealing capability, excellent red blood cell capturing property, and activation of hemostatic barrier membrane. More interestingly, the hydrogel combined with commercial hemostatic sponge presents accelerated wound healing as well as great potential for treating deep‐wound hemorrhage in a battlefield environment. Overall, owing to these unique advantages, the novel tissue‐adhesive hemostat opens up a new avenue to rapid sealing hemostasis and wound healing applications.

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“…PVA is easily soluble in water and can be frequently used as an adhesive. 24,25 In this study, we employed a versatile electrospinning technique to prepare an aligned PVA nanofibrous membrane. During electrospinning, the electrostatic repulsion will extensively pull the PVA nanofibers, and internal stresses are gradually accumulated within the aligned nanofibers.…”

Section: Biomaterials Science Papermentioning

confidence: 99%

Bioinspired aligned wrinkling dressings for monitoring joint motion and promoting joint wound healing

Zhou

Feng

Liu³

et al. 2022

Biomater. Sci.

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An ultralong hydroxyapatite nanowire aerogel for rapid hemostasis and wound healing

Cited by 53 publications

References 53 publications

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Mussel‐ and Barnacle Cement Proteins‐Inspired Dual‐Bionic Bioadhesive with Repeatable Wet‐Tissue Adhesion, Multimodal Self‐Healing, and Antibacterial Capability for Nonpressing Hemostasis and Promoted Wound Healing

Bioinspired aligned wrinkling dressings for monitoring joint motion and promoting joint wound healing

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