An ultrasensitive electrochemical DNA biosensor for monitoring Human papillomavirus-16 (HPV-16) using graphene oxide/Ag/Au nano-biohybrids

Pareek, Sakshi; Jain, Utkarsh; Bharadwaj, Mausumi; Kc, Saxena; Roy, Souradeep; Chauhan, Nidhi

doi:10.1016/j.ab.2022.115015

Cited by 27 publications

(6 citation statements)

References 44 publications

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“…GO and silver-coated gold nanoparticles were used to modify an indium tin oxide-coated glass electrode. The results indicate that the biosensor has a high sensitivity for the detection of HPV-16, and it is possible to detect it in the early stage, which can be crucial in developing point-of-care devices [44]. Bao J. et al [45] developed an electrochemical biosensor for methylated DNA detection.…”

Section: Biosensorsmentioning

confidence: 99%

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Graphene Production and Biomedical Applications: A Review

Malisz,

Świeczko-Żurek

2023

Crystals

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Graphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because of their outstanding physiochemical, mechanical, and biological properties. Graphene production techniques are divided into top-down and bottom-up synthesis methods, of which chemical vapor deposition (CVD) is the most popular. The biomedical applications of graphene and its composite include its use in sensors, implantology, and gene and drug delivery. They can be used for tissue engineering, anticancer therapies, and as antimicrobial agents in implant application. The biocompatibility of graphene-based nanomaterials enables their use in the field of biomedicine. This article reviews the properties of graphene, the methods used to produce it, the challenges associated with its use, and the potential applications of this material in biomedicine, regenerative medicine, and drug delivery systems.

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Section: Biosensorsmentioning

confidence: 99%

“…However, Pareek S. et al [44] fabricated an electrochemical DNA biosensor for human papillomavirus-16 (HPV-16) detection. Cervical cancer is caused by the HPV-16 virus.…”

Section: Biosensorsmentioning

confidence: 99%

Graphene Production and Biomedical Applications: A Review

Malisz,

Świeczko-Żurek

2023

Crystals

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“…In the other studies, to address the conductivity issue of GO, conductive metal nanoparticles were introduced to reduced GO (rGO) or the nanoribbon structure of the GO and used for the detection of miRNA-21 and Human papillomavirus-16 (HPV-16) in an electrochemical manner. 55,56 In addition, to maximize the conductivity of the rGO, a nanocomposite was developed by combining rGO and molybdenum disulde (MoS 2 ) nanoparticles, a TMD nanomaterial and was used to develop an electrochemical biosensor. 57 In this study, a carbon-based nanocomposite composed of rGO and MoS 2 nanoparticles was further combined with a conductive polymer [poly (3,4-ethoxylenedioxythiophene), PEDOT] to develop an electrochemical parathyroid hormone biosensor.…”

Section: Development Of Biosensors By Carbon-based Nanocompositesmentioning

confidence: 99%

Carbon-based nanocomposites for biomedical applications

Shin,

Lim,

Park

et al. 2024

RSC Adv.

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“…The synthesis and application of more complex materials, which combine the advantages of few components, such as polymer–carbon nanomaterial composites, still remain a topic of research that gives room for further development [ 150 ]. Such solutions may even facilitate the interactions between the nanomaterial and nucleic acids, as is quite common in the case of 1D and 2D nanomaterials decorated with nanoparticles of precious metals, mainly gold [ 151 ]. Another direction of the research trends is focused on nanoelectrodes made entirely of nanomaterials, such as graphene pastes or carbon nanotubes [ 152 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Modern Electrochemical Biosensing Based on Nucleic Acids and Carbon Nanomaterials

Szymczyk

Ziółkowski

Malinowska

2023

Sensors

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To meet the requirements of novel therapies, effective treatments should be supported by diagnostic tools characterized by appropriate analytical and working parameters. These are, in particular, fast and reliable responses that are proportional to analyte concentration, with low detection limits, high selectivity, cost-efficient construction, and portability, allowing for the development of point-of-care devices. Biosensors using nucleic acids as receptors has turned out to be an effective approach for meeting the abovementioned requirements. Careful design of the receptor layers will allow them to obtain DNA biosensors that are dedicated to almost any analyte, including ions, low and high molecular weight compounds, nucleic acids, proteins, and even whole cells. The impulse for the application of carbon nanomaterials in electrochemical DNA biosensors is rooted in the possibility to further influence their analytical parameters and adjust them to the chosen analysis. Such nanomaterials enable the lowering of the detection limit, the extension of the biosensor linear response, or the increase in selectivity. This is possible thanks to their high conductivity, large surface-to-area ratio, ease of chemical modification, and introduction of other nanomaterials, such as nanoparticles, into the carbon structures. This review discusses the recent advances on the design and application of carbon nanomaterials in electrochemical DNA biosensors that are dedicated especially to modern medical diagnostics.

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An ultrasensitive electrochemical DNA biosensor for monitoring Human papillomavirus-16 (HPV-16) using graphene oxide/Ag/Au nano-biohybrids

Cited by 27 publications

References 44 publications

Graphene Production and Biomedical Applications: A Review

Graphene Production and Biomedical Applications: A Review

Carbon-based nanocomposites for biomedical applications

Modern Electrochemical Biosensing Based on Nucleic Acids and Carbon Nanomaterials

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