Abstract-In-body antennas couple strongly to surrounding biological tissues thus resulting in radiation efficiencies well below 1%. Here, we quantify how the permittivity and conductivity, each individually, affect the radiation efficiency of miniature implantable and ingestible antennas. We use a generic pill-sized capsule antenna and a spherical homogeneous phantom with its electromagnetic properties covering the complete range of body tissues. In addition to the phantom surrounded by air, we study the case with a reduced phantom-background contrast (nonresonant case) that allows for decoupling of the obtained results from the phantom shape. The results demonstrate that, for a realistic capsule antenna, the effect of dielectric loading by tissue can partially compensate for the tissue losses. For instance, the gain of the antenna operating in the muscleequivalent medium is about two times (3 dBi) higher than in the fat-equivalent one, even though the conductivity of muscle is one order of magnitude higher than the one of fat. The results suggest that, in majority of cases, in-body devices should be designed for and be placed within higher permittivity tissues with low to moderate losses.Index Terms-biomedical telemetry, implantable, in-body, ingestible, ISM (industrial, scientific, and medical) band.