An uncommon case of arterial aneurysms association with high plasma levels
of Matrix Metalloproteinase-9 and Neutrophil Gelatinase-Associated Lipocalin

Caridi, Giovanni De; Massara, Mafalda; Spinelli, Francesco; Grande, Raffaele; Butrico, Lucia; Rende, Pierandrea; Amato, Maurizio; Compagna, Rita; Amato, Bruno; Franciscis, Stefano de; Serra, Raffaele

doi:10.1515/med-2015-0083

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Several studies have shown that MPs participate in several steps of the development of AA [ 15 , 16 ]. Increased circulating levels of neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9 have been documented in patients with AA [ 17 , 18 ]. Similarly, overexpression of several ADAMs and ADAMTS promotes AA development and expansion [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Aortic Aneurysms, Chronic Kidney Disease and Metalloproteinases

et al. 2021

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Metalloproteinases (MPs) are proteolytic enzymes involved in extracellular matrix deposition, regulation of cellular signals of inflammation, proliferation, and apoptosis. Metalloproteinases are classified into three families: Matrix-MPs (MMPs), A-Disintegrin-and-Metalloprotease (ADAMs), and the A-Disintegrin-and-Metalloproteinase-with-Thrombospondin-1-like-Domains (ADAMTS). Previous studies showed that MPs are involved in the development of aortic aneurysms (AA) and, concomitantly, in the onset of chronic kidney disease (CKD). CKD has been, per se, associated with an increased risk for AA. The aim of this review is to examine the pathways that may associate MPs with CKD and AA. Several MMPs, such as MMP-2, -8, -9, and TIMP-1 have been shown to damage the AA wall and to have a toxic effect on renal tubular cells, leading to fibrosis. Similarly, ADAM10 and 17 have been shown to degrade collagen in the AA wall and to worsen kidney function via pro-inflammatory stimuli, the impairment of the Renin-Angiotensin-Aldosterone System, and the degradation of structural proteins. Moreover, MMP-2 and -9 inhibitors reduced aneurysm growth and albuminuria in experimental and human studies. It would be important, in the future, to expand research on MPs from both a prognostic, namely, to refine risk stratification in CKD patients, and a predictive perspective, likely to improve prognosis in response to targeted treatments.

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Section: Introductionmentioning

confidence: 99%

Aortic Aneurysms, Chronic Kidney Disease and Metalloproteinases

et al. 2021

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“…An aneurysm develops in the setting of antecedent systemic infections with bacteremia or through the direct local invasion of the vessel wall (e.g., IV drug users) in the pre-existing aneurysm or atheromatous plaques [19]. The bacterial infection causes the release of pro-in ammatory cytokines, polymorphonuclear (PMN) leukocytes in ltration, and activation of matrix metalloproteinases, resulting in the focal vessel wall disintegration [20].…”

Section: Discussionmentioning

confidence: 99%

True Mycotic Aneurysms: A Report of Three Patients with Internal Carotid Artery Aneurysm and Mucormycosis, and Literature Review

Rostamihosseinkhani

Hooshmandi

Janipour

et al. 2021

Preprint

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Background Aneurysm formation of internal carotid arteries (ICA) in patients with mucormycosis is a scarce phenomenon. However, the prevalence of rhino-cerebral mucormycosis has been reported to increase after the coronavirus disease 2019 (COVID-19) pandemic. Methods Three patients with stroke and subarachnoid hemorrhage due to ICA aneurysm after the involvement of adjacent paranasal sinuses with mucormycosis were presented. All patients were recruited from Namazi and Khalili hospitals affiliated with Shiraz University of Medical Sciences in Iran from April 2021 to May 2021. Results They had a history of diabetes and corticosteroid use. Also, one of them was treated with imatinib. Two out of three patients were infected with SARS-CoV-2 infection before developing mucormycosis. Two patients had diagnostic angiography before endovascular intervention. One patient did not undergo any therapeutic intervention due to total artery occlusion, whereas the other patient experienced a successful parent artery occlusion by coiling, and only this patient survived. Although all patients received antifungal treatment and surgical debridement, two of them died. Conclusions In the patients with rhino-cerebral mucormycosis evolving of aneurysm should be promptly and meticulously investigated by magnetic resonance angiography (MRA) and computed tomography angiography (CTA). As this type of aneurysms was very fast-growing, as soon as the involvement of sphenoid sinus was detected, the possibility of ICA aneurysm formation should always be kept in mind. If the patient developed an aneurysm, prompt intensive antifungal therapy and therapeutic endovascular interventions such as stenting, coiling, or sacrificing should be considered as soon as possible to optimize outcomes.

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“…Studies have shown that increased MMP activity is associated with a higher risk of aortic rupture [91].…”

Section: Pathogenesismentioning

confidence: 99%

Mycotic Thoracic Aortic Aneurysm: Epidemiology, Pathophysiology, Diagnosis, and Management

Raavi¹,

Garg²,

Hussain³

et al. 2022

Cureus

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Mycotic thoracic aortic aneurysm (MTAA) is an aneurysm of the aorta caused by infection of the vessel tissue through microbial inoculation of the diseased aortic endothelium. It is most commonly caused by bacteria. Rarely, it can be caused by fungi. However, viral aortic aneurysm has never been reported. Depending on the area and time period investigated, the infections organism discovered may vary significantly. Little is known about the natural history of MTAA due to its rarity. It is not known if they follow the same pattern as other TAAs. However, it is unclear whether MTAA follows a similar clinical course. The combination of clinical presentation, laboratory results, and radiographic results are used to make the diagnosis of MTAA. Treatment of MTAA is complex since patients frequently present at a late stage, frequently with fulminant sepsis, as well as concomitant complications such as aneurysm rupture. While medical treatment, including antibiotics, is recommended, surgery is still the mainstay of management. Surgery to treat MTAA is complicated and carries a high risk of morbidity and mortality and includes both open repairs and endovascular ones. In this review, we explore the etiology, pathogenesis, clinical presentations, diagnostic modalities as well as treatment management available for MTAA.

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An uncommon case of arterial aneurysms association with high plasma levels of Matrix Metalloproteinase-9 and Neutrophil Gelatinase-Associated Lipocalin

Cited by 8 publications

References 26 publications

Aortic Aneurysms, Chronic Kidney Disease and Metalloproteinases

Aortic Aneurysms, Chronic Kidney Disease and Metalloproteinases

True Mycotic Aneurysms: A Report of Three Patients with Internal Carotid Artery Aneurysm and Mucormycosis, and Literature Review

Mycotic Thoracic Aortic Aneurysm: Epidemiology, Pathophysiology, Diagnosis, and Management

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