An unexplored remarkable PNIPAM-osmolyte interaction study: An integrated experimental and simulation approach

Narang, Payal; Vepuri, Suresh B.; Venkatesu, Pannuru; Soliman, Mahmoud E. S.

doi:10.1016/j.jcis.2017.05.109

Cited by 34 publications

(19 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To evaluate the effect of temperature T on equilibrium swelling curves, simulation is conducted of the governing equations for swelling of PNIPA gel in solutions of glucose with various volume fractions f , where predictions of eqn (32) are compared with experimental data. [65][66][67] Good agreement is demonstrated between predictions of the model and experimental data for the critical temperature of PNIPA gel in solutions of glucose and galactose. Slight deviations (less than 2 C, that is the width of the volume phase transition interval for PNIPA gel) between the data and results of simulation in Fig.…”

Section: Fitting Of Observationsmentioning

confidence: 58%

See 1 more Smart Citation

The effect of saccharides on equilibrium swelling of thermo-responsive gels

Drozdov

Christiansen

2020

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Fitting Of Observationsmentioning

confidence: 58%

“…S-7C † may be explained by the nonstandard technique used in ref. 67 for measurements of T c . The coefficient K in Table S-4 † can be connected with hydration number n of additives in aqueous solutions.…”

Section: Fitting Of Observationsmentioning

confidence: 99%

The effect of saccharides on equilibrium swelling of thermo-responsive gels

Drozdov

Christiansen

2020

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…In particular, the decrease of LCST of PNIPAM chains on increasing the concentration of trehalose has been found significantly larger compared to other saccharides and polyols [46,48], while the influence of trehalose on the corresponding swelling behavior of PNIPAM microgels is still unexplored. Also information from molecular dynamics simulation are missing, with the exception of the work of Narang et al [48], where the numerical investigation is limited to the effect on the PNIPAM-water interaction induced by the addition of a single trehalose molecule in a system containing one PNIPAM chain (35-mer) and 4370 water molecules. This solvent composition corresponds to a very low trehalose concentration (≈ 0.012 M), unable to change the polymer LCST compared to that in pure water (Table S1 of ref.…”

Section: Introductionmentioning

confidence: 98%

“…In this context, it is worth studying the specific effect of this biologically relevant sugar on the collapse of PNIPAM-based architectures. The PNIPAM-watertrehalose ternary system is much less investigated both experimentally and numerically as compared to any other ternary system of the same polymer, including those containing saccharides [44][45][46][47][48][49]. Experimental investigations using cloud point measurements, differential scanning and isothermal titration-microcalorimetry [44,46], report a significant decrease of LCST of PNIPAM chains in aqueous solution on increasing mono-and disaccharide concentration, finding a good correlation of the saccharide hydration with the decrease of LCST, and hence with the promotion of the globular compact state of the polymer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thermoresponsivity of poly(N-isopropylacrylamide) microgels in water-trehalose solution and its relation to protein behavior

Rosi,

Tavagnacco,

Comez

et al. 2021

Preprint

View full text Add to dashboard Cite

In this work we use a multi-technique approach to gain new insights into the effects of trehalose on the volume phase transition of poly(N-isopropylacrylamide) (PNIPAM) microgels, a model synthetic biomimetic system. By dynamic light scattering the temperature-dependent microgel hydrodynamic volume is monitored, while Raman spectroscopy and molecular dynamics simulations explore at the molecular scale changes of solvation and dynamics across the transition. At 0.72 M trehalose concentration the phase transition temperature is lowered by ≈ 10 K, with a concomitant decrease of transition enthalpy not compensated by a corresponding reduction in transition entropy. In water-trehalose solution the microgel particles are ≈ 20% more expanded than in pure water, keeping unchanged their thermal contraction, swelling capacity, and the amount of absorbed water. Strongly hydrated trehalose molecules mainly develop water-mediated interactions with PNIPAM, thus preserving the polymer hydration state both before and after the transition. However, the presence of trehalose deeply impacts on the dynamics of the system, with a drastic slowing down of PNIPAM motions and of its hydration shell. Our investigation reveals a coherent picture in which trehalose sustains hydration and favors, both thermodynamically and kinetically, the collapsed conformation of the microgel, by inhibiting local motions of polymer residues and water.

show abstract

Stimuli‐responsive polypeptoid block copolymers containing o‐nitrobenzyl groups with extremely sharp transition

Lin

et al. 2022

Journal of Polymer Science

View full text Add to dashboard Cite

Bioinspired thermoresponsive polymers have received increasing attention for many applications. Here, we report a series of thermoresponsive polypeptoid block copolymers containing o-nitrobenzyl groups, that is, poly(ethylene glycol)-b-poly[N-[2-[N-(o-nitrobenzyloxycarbonyl)-amino]-ethyl]-glycine] (PEG-b-PN[oNB]G), prepared by ring-opening polymerization. The polypeptoid block copolymers show reversible lower critical solution temperature (LCST)-type behavior in water with tunable phase transition properties dependent on the pH values, chemical compositions, and concentrations of the copolymers. The dynamic light scattering results reveal the formation of spherical micelles and temperature-induced aggregation of PEG-b-PN(oNB)G. Notably, the phase transition of the block copolymer solution upon heating appears extremely sharp (ΔT < 1 C), superior to bench mark poly(N-isopropylacrylamide).In addition, we present the removal of photo-responsive o-nitrobenzyl groups can result in the increased clouding point and even the loss of phase transition properties, acting as an excellent regulator to tune the LCST behavior. We demonstrate that the hydrogen-bonding interaction may play a critical part on the LCST behavior. The prepared diblock copolymers show great potential for many applications and its structure-property may shed light on highly designable stimuli-responsive polymeric materials.

show abstract

An unexplored remarkable PNIPAM-osmolyte interaction study: An integrated experimental and simulation approach

Cited by 34 publications

References 58 publications

The effect of saccharides on equilibrium swelling of thermo-responsive gels

The effect of saccharides on equilibrium swelling of thermo-responsive gels

Thermoresponsivity of poly(N-isopropylacrylamide) microgels in water-trehalose solution and its relation to protein behavior

Stimuli‐responsive polypeptoid block copolymers containing o‐nitrobenzyl groups with extremely sharp transition

Contact Info

Product

Resources

About