An Unusual Case of Aldosterone- and Norepinephrine-Secreting Retroperitoneal Leiomyosarcoma

Abstract

A case of retroperitoneal leiomyosarcoma (LMS) in a 38-year-old woman who had a tumor in the retroperitoneum with severe hypertension and hypokalemia is presented. Further investigation revealed an elevated serum aldosterone and norepinephrine level. After tumorectomy, the levels of serum aldosterone and norepinephrine successfully normalized; hypertension and hypokalemia were also cured. The tumor was diagnosed as being a LMS by pathologic examination. We suggested that this was the first case of retroperitoneal LMS shown to be associated with increased levels of serum aldosterone and norepinephrine.

Laparoscopic Management of Suprarenal Leiomyosarcoma: A Case Report

“…Retroperitoneal leiomyosarcoma, one of the soft-tissue sarcomas, is relatively rare and comprises < 1% of all malignancies [1]. Approximately 70% of all leiomyosarcomas are found in the retroperitoneal region [2].…”