An Unusual Case of Primary Retroperitoneal Germ Cell Tumour in a Young Man

Serpa, M.J.; Franco, Susana; Repolho, Diana; Branco, Francisco; Gramaça, João; Júnior, José Ferreira

doi:10.12890/2018_000900

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…However, there are some studies on the abnormal expression of LDH in tumors, and many scholars take it as one of the prognostic indicators [ 15 , 16 ]. Existing studies have demonstrated that elevated LDH in tumor tissue is associated with the clinical outcomes of multiple cancers, including renal cell carcinoma, melanoma, prostate cancer, lung cancer, and colorectal cancer [ 17 , 18 ]. Could α-HBDH also be a biomarker for the prognosis and diagnosis of lung cancer?…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of serum α-HBDH levels in patients with lung cancer

Zhang¹,

Wang

Chen

2023

World J Surg Onc

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Background The purpose of our study is to investigate the expression level and prognostic value of serum α-hydroxybutyrate dehydrogenase (α-HBDH) in lung cancer (LC) patients. Method LC patients treated in the Department of Oncology, Shaanxi Provincial Cancer Hospital from January 2014 to December 2016 were included in this study, all of whom underwent serological detection of α-HBDH prior to admission, and were enrolled in follow-up 5-year survival. Comparing the differences between high group and normal groups based on α-HBDH and LDH expression via clinicopathological parameters and laboratory data. Univariate and multivariate regression and overall survival (OS) were analyzed to explore whether elevated α-HBDH was an independent risk factor for LC, compared to LDH. Results Multivariate regression analysis showed that age (P = 0.018), liver metastasis (P = 0.011), α-HBDH (P = 0.015), and neutrophil-to-lymphocyte ratio (NLR) (P = 0.031) were independent prognostic factors affecting OS in LC patients. The overall diagnostic efficacy of α-HBDH (AUC = 0.887) was higher than that of LDH (AUC = 0.709) in the ROC curve. The sensitivity was significantly higher of α-HBDH (sensitivity: 76.06%, specificity: 94.87%) compared with LDH (sensitivity: 49.30%, specificity: 94.87%). The median of OS was more significant in the high-α-HBDH group (6.4 months) than in the normal-α-HBDH group (12.7 months) (P = 0.023). The median of OS was significant in the high-LDH (> 245 U/L) group at 5.8 months and 12.0 months in the normal-LDH (≤ 245 U/L) group (P = 0.068). Conclusions Elevated expression of α-HBDH may indicate a poor prognosis of LC patients. It has a higher sensitivity than LDH and can be used as a potential early biomarker and an independent risk factor predicting the prognosis of LC survival.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of serum α-HBDH levels in patients with lung cancer

Zhang¹,

Wang

Chen

2023

World J Surg Onc

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Primary retroperitoneal germ cell tumor in an adult female

2020

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Rationale: Primary retroperitoneal germ cell tumors are uncommon and especially rare in female patients. However, this type should be included in the differential diagnosis of retroperitoneal tumors that may metastasize from the gonads and be a primary tumor. Patient concerns: An abdominal mass was detected in a 38-year-old woman during physical examination, which was accompanied by left renal obstructive hydrops. She was admitted to our institution for further investigation. The patient had no obvious clinical symptoms, and the levels of serum tumor markers did not signifificantly increase. Abdominal noncontrast enhanced and contrast-enhanced computed tomography revealed a retroperitoneal neoplasm that invaded the left ureter, thereby causing left hydronephrosis. Diagnoses: Imaging examination characterized the tumor as malignant based on its invasion in the left ureter. Histopathology and immunohistochemistry confifirmed the resected tumor as a dysgerminoma. The primary gonad-derived germ cell tumor was not found in the pelvis; therefore, the patient was fifinally diagnosed with primary retroperitoneal germ cell tumor. Interventions: Preoperative examination was completed, and the retroperitoneal mass was resected. Outcomes: During the short-term follow-up, no tumor recurrence was detected. Lessons: Primary retroperitoneal seminoma should be included in the differential diagnosis of primary retroperitoneal tumors in female patients. The primary retroperitoneal seminoma/anaplastic tumor has an obvious occupying effect and can easily invade the surrounding structures. However, surgical resection of such tumors is an optional treatment strategy.

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An Unusual Case of Primary Retroperitoneal Germ Cell Tumour in a Young Man

Cited by 2 publications

References 6 publications

Prognostic value of serum α-HBDH levels in patients with lung cancer

Prognostic value of serum α-HBDH levels in patients with lung cancer

Primary retroperitoneal germ cell tumor in an adult female

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