An unusual case of reversible acute kidney injury due to chlorine dioxide poisoning

Bathina, Gangadhar; Yadla, Manjusha; Burri, Srikanth; Enganti, Rama; Prasad, Rajendra; Deshpande, Pradeep; Ch, Ramesh; Prayaga, Aruna K; Uppin, Megha S

doi:10.3109/0886022x.2013.819711

Cited by 20 publications

(16 citation statements)

References 4 publications

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“…• Reporte de un caso de lesión renal aguda debido a la intoxicación por dióxido de cloro (Bathina et al, 2013).…”

Section: Documentación Científica Sobre La Toxicidad Asociada a La Utilización Del Mms Y Otrosunclassified

Sobre el uso del dióxido de cloro en ámbitos de la salud humana y la importancia del razonamiento crítico

Maldonado¹

2021

Jour. Bol. Cien.

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Desde hace algunos años, productos como el dióxido de cloro, clorito de sodio y suplemento mineral milagroso (o MMS por sus siglas en inglés), a pesar de no haber sido certificados como medicamentos, están siendo utilizados de manera alternativa por muchas personas para el tratamiento de diferentes enfermedades. Este uso se ha visto incrementado durante la actual crisis por la pandemia por COVID-19. En este documento, se proporciona una lista no exhaustiva de publicaciones científicas y advertencias oficiales respecto al uso potencialmente peligroso de estos productos en el área de la salud humana. Toda la información citada es bien conocida por profesionales de ramas afines a la bioquímica y farmacéutica, pero no siempre es accesible al público en general. Además, se proporcionan elementos de razonamiento crítico para ayudar a la población en general a procesar la evidencia científica disponible y así construir una opinión propia e independiente

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“…• Reporte de un caso de lesión renal aguda debido a la intoxicación por dióxido de cloro (Bathina et al, 2013).…”

Section: Documentación Científica Sobre La Toxicidad Asociada a La Utilización Del Mms Y Otrosunclassified

Sobre el uso del dióxido de cloro en ámbitos de la salud humana y la importancia del razonamiento crítico

Maldonado¹

2021

Jour. Bol. Cien.

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“…The blood is especially sensitive to this oxidative stress, whereby hemoglobin can be oxidized to methemoglobin. Thus, cell membranes may be subjected to oxidative crosslinking of spectrin and lipid peroxidation leading to intravascular hemolysis (Bathina et al, 2013;Couri, Abdel-Rahman, & Bull, 1982;EFSA, 2015).…”

Section: Oxidative Stressmentioning

confidence: 99%

“…The interconversion between chlorite, chlorate, and chloride occurs in the gut and has been found to cause oxidative stress within the body (Bathina et al., ). The body has many antioxidant mechanisms to protect its cells from this process, mainly the glutathione (GSH) redox cycle.…”

Section: Health Impact Of Oxychlorine Speciesmentioning

confidence: 99%

“…The body has many antioxidant mechanisms to protect its cells from this process, mainly the glutathione (GSH) redox cycle. However, when the oxidative stress is too high it can overcome this defense mechanism and cause substantial injury to the cells, proteins, lipids, and amino acids (Bathina et al., ; EFSA, ). The blood is especially sensitive to this oxidative stress, whereby hemoglobin can be oxidized to methemoglobin.…”

Section: Health Impact Of Oxychlorine Speciesmentioning

confidence: 99%

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Chlorate and Other Oxychlorine Contaminants Within the Dairy Supply Chain

McCarthy

O’Callaghan

Danahar

et al. 2018

Comp Rev Food Sci Food Safe

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The presence of chlorate in milk and dairy products can arise from the use of chlorinated water and chlorinated detergents for cleaning and sanitation of process equipment at both farm and food processor level. Chlorate and other oxychlorine species have been associated with inhibition of iodine uptake in humans and the formation of methemoglobin, with infants and young children being a high‐risk demographic. This comprehensive review of chlorate and chlorine derivatives in dairy, highlights areas of concern relative to the origin and/or introduction of chlorate within the dairy supply chain. This review also discusses the associated health concerns, regulations, and chemical behavior of chlorate and chlorine‐derived by‐products, and provides a summary of mechanisms for their detection and removal.

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“…According to the Food and Drug Administration (FDA) of the US, consuming ClO 2 can lead to adverse effects such as ‘vomiting, diarrhoea, dehydration, abdominal pain, metahemaglobinemia and systemic failures that could potentially lead to death’. However, an impartial review of the scientific peer-reviewed literature reveals few case reports of human patients presenting adverse effects after consumption of ClO 2 , none of which were fatal, and in all cases reversed completely after treatment (Kishan, 2009; Bathina et al, 2013; Romanovsky et al, 2013; Loh and Shafi, 2014). Published studies on ClO 2 toxicity have reported null to mild effects in adult humans and other animals (e.g.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antiviral effect of chlorine dioxide (ClO₂) using a vertebrate model inoculated with avian coronavirus

Zambrano-Estrada

Domínguez-Sánchez

Banuet-Martínez

et al. 2020

Preprint

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The need for safe and effective antiviral treatments is pressing, particularly given the number of viral infections that are prevalent in animal and human populations, often causing devastating economic losses and mortality. In the context of the current coronavirus pandemic, which has highlighted how devastating the effects of a virus can be on a naive population, it is imperative to have rigorous and unbiased data on the efficacy and safety of potential antiviral treatments, particularly those that have demonstrated virucidal effects as a disinfectant, are being considered for use despite warnings on their potential toxicity, but no not have empirical evidence of their antiviral effect in vivo. Here, we tested the effect of chlorine dioxide (ClO2) on chick embryos infected with avian infectious bronchitis coronavirus (IBV). We determined virus-induced mortality on 10-day old embryos inoculated with 104 mean EID50/mL of attenuated Massachusetts and Connecticut IBV strains. We determined viral titres using RT-qPCR and conducted histopathological examination of various tissues and organs. Viral titres were 2.4-fold lower and mortality was reduced by half in infected embryos that were treated with ClO2. Infection led to developmental abnormalities regardless of treatment. Lesions typical of IBV infections were observed in all inoculated embryos, but severity tended to be lower in ClO2-treated embryos. We found no gross or microscopic evidence of toxicity caused by ClO2 at the doses used herein. Our study shows that ClO2 could be a safe and viable option for controlling avian coronavirus, and raises the possibility that similar effects could be observed in other organisms.

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An unusual case of reversible acute kidney injury due to chlorine dioxide poisoning

Cited by 20 publications

References 4 publications

Sobre el uso del dióxido de cloro en ámbitos de la salud humana y la importancia del razonamiento crítico

Sobre el uso del dióxido de cloro en ámbitos de la salud humana y la importancia del razonamiento crítico

Chlorate and Other Oxychlorine Contaminants Within the Dairy Supply Chain

Evaluation of the antiviral effect of chlorine dioxide (ClO₂) using a vertebrate model inoculated with avian coronavirus

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An unusual case of reversible acute kidney injury due to chlorine dioxide poisoning

Cited by 20 publications

References 4 publications

Sobre el uso del dióxido de cloro en ámbitos de la salud humana y la importancia del razonamiento crítico

Sobre el uso del dióxido de cloro en ámbitos de la salud humana y la importancia del razonamiento crítico

Chlorate and Other Oxychlorine Contaminants Within the Dairy Supply Chain

Evaluation of the antiviral effect of chlorine dioxide (ClO2) using a vertebrate model inoculated with avian coronavirus

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Product

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About

Evaluation of the antiviral effect of chlorine dioxide (ClO₂) using a vertebrate model inoculated with avian coronavirus