An unusual case of secondary syphilis misdiagnosed as allergic dermatitis for 2 years

Wang, Hongwei; Chen, Renhe; Zhang, Ru‐Zhi

doi:10.1002/ccr3.3229

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…The first recommended technique is the use of immunohistochemistry for Treponema. The presentation of syphilis with involvement of the upper lip is a characteristic clinical profile in the literature, serving as a manifestation of primary syphilis (chancre), secondary syphilis, [4][5][6][7][8][9][10] and even tertiary syphilis. 11,12 In some cases, there may be no evidence of sexual transmission.…”

Section: Discussionmentioning

confidence: 99%

Cocaine-Induced Plasma Cell Orificial “Dermatomucositis”: A More Accurate Descriptive Term for a Clearly Dermatological Entity

Fernandez-Flores,

González Montero

2024

The American Journal of Dermatopathology

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Although the involvement of the nasal passages and nasal septum in cocaine users has been known for decades, a new presentation affecting the nostrils and upper lip with an inflamed appearance has recently been documented. The authors who identified this presentation termed it “cocaine-related plasma cell mucositis” due to the abundance of plasma cells in the infiltrate. In this article, we present a second case and emphasize the dermal involvement of the lip, leading us to consider the condition as a genuine dermatomucositis.

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Section: Discussionmentioning

confidence: 99%

Cocaine-Induced Plasma Cell Orificial “Dermatomucositis”: A More Accurate Descriptive Term for a Clearly Dermatological Entity

Fernandez-Flores,

González Montero

2024

The American Journal of Dermatopathology

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“…Syphilis is primarily spread through direct contact with infected skin or mucous membranes, particularly during sexual activity, and it is not considered to be highly contagious through casual contact or sharing of personal belongings. However, in some cases, sharing personal items such as toothbrushes, and other grooming tools may be associated with a risk of transmission if contaminated blood is present on the item [55,56].…”

Section: Discussionmentioning

confidence: 99%

The HIV and Syphilis Seroprevalence and Associated Risk Factors among Incarcerated Individuals in Port Harcourt

Mike-Ogburia¹

2023

J Infect Dis Case Rep

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Infectious diseases like HIV and syphilis are a significant burden in prisons, where they are more prevalent than in the general population. The confined unhygienic living conditions and high-risk behaviours contribute to the spread of infections among incarcerated individuals. This study was therefore aimed at investigating the prevalence of HIV and syphilis among inmates incarcerated in Port Harcourt, Nigeria.

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“…Secondary syphilis presents approximately 2-12 weeks after the primary stage with maculopapular skin rashes which may affect one or more areas of the body or mucous membrane lesions [4,12,13]. The most common cutaneous presentation is generalized, nonpruritic, symmetrical macular eruptions, which are frequently distributed on the trunk, palms, and soles, called syphilitic rosette [14].…”

Section: Introductionmentioning

confidence: 99%

Oral Secondary Syphilis in an HIV-Positive Transgender Patient: A Case Report and Review of the Literature

Mauceri,

Coppini,

Cascio

et al. 2023

Dentistry Journal

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Background: Syphilis is a worldwide sexually transmitted infection caused by Treponema pallidum. In most cases, the oral manifestations of syphilis infection are associated with cutaneous involvement. However, the present case report is noteworthy since the oral lesions are the sole clinical sign in an HIV-positive transgender patient. Case presentations: We reported an uncommon case of secondary syphilis in a 37-year-old seropositive transgender male, whose diagnostic suspect was based only on oral mucosal lesions. The patient was referred to the Oral Medicine Unit for the presence of multiple undiagnosed painful oral lesions. The intraoral examination revealed the presence of white and red plaques on the right and the left buccal mucosa and several painful lesions localized on the upper and lower labial mucosa. No cutaneous lesions were observed. Considering the sexual history of the patient and clinical findings, secondary syphilis infection was suspected. The serologic analysis was conducted, and the diagnosis of syphilis was confirmed. Moreover, to exclude the presence of oral epithelial dysplasia or malignant disease, an incisional biopsy was performed. Discussion: Compared to the literature data, oral lesions as lone signs of secondary syphilis infection are uncommon, especially in HIV-positive patients. Syphilis and HIV coinfection create a concerning situation as they interact synergistically, leading to an increased risk of transmission and faster disease progression. Conclusions: This case report emphasizes the importance of considering syphilis as a diagnostic possibility, even when oral lesions are the only clinical manifestations, especially in HIV-positive patients. Comprehensive evaluation, including a detailed sexual history and careful oral examination, is essential for accurate diagnosis and appropriate management in such cases.

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An unusual case of secondary syphilis misdiagnosed as allergic dermatitis for 2 years

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 9 publications

Cocaine-Induced Plasma Cell Orificial “Dermatomucositis”: A More Accurate Descriptive Term for a Clearly Dermatological Entity

Cocaine-Induced Plasma Cell Orificial “Dermatomucositis”: A More Accurate Descriptive Term for a Clearly Dermatological Entity

The HIV and Syphilis Seroprevalence and Associated Risk Factors among Incarcerated Individuals in Port Harcourt

Oral Secondary Syphilis in an HIV-Positive Transgender Patient: A Case Report and Review of the Literature

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