An unusual case of sporotrichoid nodules: Metastatic cutaneous squamous cell carcinoma

Abstract

A 63-year-old immunocompetent patient presented with a 4 month history of 12 painless nodules in a linear array on his right arm. He had a history of a surgery for a cutaneous tumor on the dorsum of his right middle finger about a year prior, but he did not follow up after the surgery. A differential diagnosis of sporotrichosis, atypical mycobacteria, deep fungal infection, and metastatic cutaneous squamous cell carcinoma (SCC) was considered. Skin biopsy revealed islands of dysplastic squamous cells and keratin pearls in a desmoplastic stroma in the deep dermis and subcutaneous tissue. The behavior of the disease was very aggressive, with rapid dissemination in a linear array, mimicking an infectious sporotrichoid spread. To our knowledge, this is the second case report of sporotrichoid metastases to the skin from cutaneous SCC in an immunocompetent patient.

FABP7 inhibits proliferation and invasion abilities of cutaneous squamous cell carcinoma cells via the Notch signaling pathway

“…Cutaneous squamous cell carcinoma (CSCC) is common among elderly individuals and severely impacts the life quality, as well as poses a threat to their lives ( 1 , 2 ). CSCC is characterized by small nodules on the surface of the skin, which gradually become larger and harder to form cauliflower-like hyperplasia ( 3 ). A number of patients experience ulceration in the lesions, which gradually increases, accompanied by symptoms such as pus, bleeding and foul odor ( 4 ).…”