An Unusual Case of Syringocystadenocarcinoma Papilliferum In Situ With Macular Amyloidosis

Singh, Saurabh; Khullar, Geeti; Sharma, Tarun; Elhence, Poonam

doi:10.1001/jamadermatol.2017.0397

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…A PubMed literature search revealed—including our newly reported case—53 cases of SCACP (Table 1). 3–6,10–43 SCACP occurred at middle and older ages (range: 22–93 years, median age of 65.5 years). The male to female ratio was 1.3:1 indicating a slight male predominance.…”

Section: Discussionmentioning

confidence: 99%

Nevus Sebaceous of the Scalp With Stepwise Progression Into Invasive Syringocystadenocarcinoma Papilliferum

Kneitz

Goebeler

Rütten

2021

The American Journal of Dermatopathology

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Syringocystadenocarcinoma papilliferum (SCACP), the malignant counterpart of syringocystadenoma papilliferum (SCAP), is an extremely rare malignant adnexal neoplasm. It is described by the World Health Organization as a malignant transformation of SCAP occurring in middle-aged to elderly individuals with a predilection for the head and neck. SCACP seems to arise from a long-standing syringocystadenoma probably on a background of nevus sebaceous (NS) through a multistep progression. A 75-yearold man was referred to our department with a long-standing NS with a recent newly developing nodule on his scalp. The tumor was excised. On histology, the overall architecture of the tumor still resembled an unusual SCAP within NS but simultaneously showed transition to syringocystadenocarcinoma papilliferum in situ and invasive SCACP as recognizable by the presence of areas of nuclear atypia, increased proliferative activity, and infiltrative growth. In summary, we report an extremely rare case of an invasive SCACP of the scalp that demonstrates histological evidence for all transitive steps in the hypothetical multistep progression from NS to invasive SCACP in one single lesion. The implications of these findings are discussed in the light of the relevant literature.

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Section: Discussionmentioning

confidence: 99%

Nevus Sebaceous of the Scalp With Stepwise Progression Into Invasive Syringocystadenocarcinoma Papilliferum

Kneitz

Goebeler

Rütten

2021

The American Journal of Dermatopathology

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“…It is typically presented as brownish or blackish spots or macules with a reticular, rippled, or homogeneous appearance. 6 The lesions are preferentially located in the extensor surfaces of the legs, the arms, and the upper back. Macular amyloidosis has a diversity of manifestations including the extensive diffused pigmentation, nevoid-like hyperpigmentation, poikiloderma-like presentation, or incontinentia pigmenti-like pattern.…”

Section: Discussionmentioning

confidence: 99%

“…Macular amyloidosis has a diversity of manifestations including the extensive diffused pigmentation, nevoid-like hyperpigmentation, poikiloderma-like presentation, or incontinentia pigmenti-like pattern. 3,4,6 It may exhibit hyperpigmented macules that are arranged in a distinctive linear, reticulated, or blaschkoid configuration. These miscellaneous clinical variations always pose a diagnostic challenge for the clinicians.…”

Section: Discussionmentioning

confidence: 99%

“…MA is disposed to adult female from Asia and South American populations. It is typically presented as brownish or blackish spots or macules with a reticular, rippled, or homogeneous appearance . The lesions are preferentially located in the extensor surfaces of the legs, the arms, and the upper back.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions are preferentially located in the extensor surfaces of the legs, the arms, and the upper back. Macular amyloidosis has a diversity of manifestations including the extensive diffused pigmentation, nevoid‐like hyperpigmentation, poikiloderma‐like presentation, or incontinentia pigmenti‐like pattern . It may exhibit hyperpigmented macules that are arranged in a distinctive linear, reticulated, or blaschkoid configuration.…”

Section: Discussionmentioning

confidence: 99%

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Brownish macules on the right temple

Liu

Ding

Tan

2019

J of Cosmetic Dermatology

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A 28-year-old male presented with multiple pigmented macules on his right temple over two years. Physical examination showed multiple, discrete, brownish macules on his right temple. These lesions coalesced into reticular shape. Histology of the lesion demonstrated a deposit of eosinophilic acellular material in the dermal papillae.These features were consistent with macular amyloidosis (MA). Macular amyloidosis typically presented over the legs, the arms, and the upper back. We present this patient of MA involving the temple areas, which, to the best of our knowledge, has not previously been reported to occur in this region. K E Y W O R D S amyloidosis, hyperpigmentation, macules, temple How to cite this article: Liu C., Ding L.-J., Tan C. Brownish macules on the right temple. J Cosmet Dermatol.

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Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges

Wan,

Park,

Khachemoune

2024

Arch Dermatol Res

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An Unusual Case of Syringocystadenocarcinoma Papilliferum In Situ With Macular Amyloidosis

Cited by 5 publications

References 6 publications

Nevus Sebaceous of the Scalp With Stepwise Progression Into Invasive Syringocystadenocarcinoma Papilliferum

Nevus Sebaceous of the Scalp With Stepwise Progression Into Invasive Syringocystadenocarcinoma Papilliferum

Brownish macules on the right temple

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges

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