An unusual focus of extra pulmonary tuberculosis

Sharma, Neeraj; Sharma, Abha; Pujani, Mukta; Kohli, Sunil

doi:10.18203/2349-3933.ijam20151025

Cited by 29 publications

(37 citation statements)

References 6 publications

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“…Although microscopic examination for acid-fast bacilli (AFB) is rapid and inexpensive, it has poor sensitivity and specificity and is unable to differentiate between tuberculous and nontuberculous mycobacteria (NTM) [4]. Histological examination has its limitations as it cannot differentiate between TB and other related diseases like sarcoidosis or NTM infections except for the determination of stained tubercle bacilli.…”

Section: Introductionmentioning

confidence: 99%

Use of GeneXpert Assay for Diagnosis of Tuberculosis From Body Fluid Specimens, a 2 Years Study

Kn¹

2016

OAJMB

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Tuberculosis (TB) remains a major health concern worldwide and India accounts for 23% of the global TB burden. Of all TB cases, extra pulmonary (EP) TB in India accounts for 15 to 20% that remains undetected and untreated not only due to its diverse clinical presentation but also due to lack of diagnostic means. EPTB poses a greater diagnostic challenge in HIV co-infected patients and children. Also with some forms of EPTB like TB meningitis, consequences can be lifethreatening. Early detection of TB and multidrug resistance is a priority in the diagnosis of TB for early disease management. In 2013, the World Health Organization has endorsed the use of GeneXpert MTB/RIF assay, a fullyautomated cartridge based nucleic acid amplification test for the rapid diagnosis of EPTB. We aimed to use the GeneXpert assay on body fluid specimens from patients with strong clinical suspicion, were hospitalized and the microscopic examination was negative for Acid-fast bacilli. GeneXpert assay was performed on 378 body fluid samples that consisted of 164 pleural fluids, 148 CSF, 59 ascitic fluid and 7 other body fluid (synovial, pericardial, peritoneal) specimens. Of these, 32 specimens were positive for MTB with a positivity rate of 10.1%, 8.8% and 9.3% respectively for pleural fluids, CSF and ascitic fluid. Rifampicin resistance was detected in 4 of the pleural fluid and one of the ascitic fluid samples.Collectively, 19.2% of the MTB positives in our study were multidrug resistant (MDR) TB. Thus the results suggest that GeneXpert assay has a good potential in the rapid accurate diagnosis of EPTB especially in body fluids, aids in prompt initiation of appropriate therapy and improving the quality of TB care.

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Section: Introductionmentioning

confidence: 99%

Use of GeneXpert Assay for Diagnosis of Tuberculosis From Body Fluid Specimens, a 2 Years Study

Kn¹

2016

OAJMB

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“…Lymph nodes are the most common site of involvement followed by pleural effusion and virtually every site of the body can be affected. 8 The association of tuberculosis with cancers and other infectious diseases due to impaired cellular immunity has also been reported and three such exotic associations are presented in this series. The timely diagnosis of EPTB remains a major challenge to physicians due to the frequently atypical clinical presentation that simulates other inflammatory and neoplastic conditions, often resulting in delay or deprivation of treatment.…”

Section: Discussionmentioning

confidence: 86%

“…smear microscopic examination, culture test (both manual and automated), serological assays (both antigen and antibody detection), histological /cytological examination, Mantoux test, PCR assays (conventional as well as real-time PCR). 8 Sophisticated imaging techniques such as CT Scan and MRI and procedures such as laparoscopy and endoscopy have tremendously helped in the anatomical localization of EPTB and also to obtain tissue for biopsies for a definitive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Exotic associations and presentations of an age old disease: spectrum of tuberculosis in a developing country

et al. 2016

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“…They can move through the blood to other parts of the body. [8] 2) Extra Pulmonary-When TB bacteria can settle the other parts of the body such as bone, brain.…”

Section: Introductionmentioning

confidence: 99%

A Bayesian Classification Approach for Mycobacterium Tuberculosis in Uttarakhand

Puri¹,

Chauhan²,

Dobhal³

2015

IJCA

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Medical data mining tools have dramatically impacted the health care industry by improving the diagnosis of medical. Tuberculosis is disease caused by bacteria, called Mycobacterium tuberculosis, TB usually attacks the lungs, but also bacteria can attack any part of the body such as kidney or brain. This Paper describes a method Bayesian classification for automated mycobacterium tuberculosis detection in tissues. Bayesian Classification approach is used to classify in 2 classes:-Pulmonary and Extra Pulmonary, Bayesian classification approach able to produce better performance with some input feature compared to the association method [7].

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An unusual focus of extra pulmonary tuberculosis

Cited by 29 publications

References 6 publications

Use of GeneXpert Assay for Diagnosis of Tuberculosis From Body Fluid Specimens, a 2 Years Study

Use of GeneXpert Assay for Diagnosis of Tuberculosis From Body Fluid Specimens, a 2 Years Study

Exotic associations and presentations of an age old disease: spectrum of tuberculosis in a developing country

A Bayesian Classification Approach for Mycobacterium Tuberculosis in Uttarakhand

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