An unusual membrane‐bound body in rat periosteal cells

Yeager, Vernon L.

doi:10.1002/aja.1001420109

Am. J. Anat.

1975

DOI: 10.1002/aja.1001420109

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An unusual membrane‐bound body in rat periosteal cells

Vernon L. Yeager

Abstract: Cytoplasmic inclusions have been found in both normal and stimulated rat periosteal cells. These inclusions are bounded by a pentilaminar membrane similar to a tight junction and contain a core of granular material. The origin and function of this inclusion are unknown.

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Cited by 4 publications

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Demonstration of giant and anular nexus in the psoriatic epidermis

Mahrle

1978

Arch Dermatol Res

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In the psoriatic skin, nexus were most prominent in the upper layers of the viable epidermis, using the Alcian blue-Lanthanum technique. There, they reached double and manifold the length (giant nexus) of those in normal epidermis. According to the villous transformation of the epidermal cell surface in psoriasis, the nexus showed a great variation in their shape. Undulating nexus were seen beside invagination--and anular nexus. On ther other hand, nexus were lacking in the deepest layers of the psoriatic epidermis in contrast to normal epidermis. From these findings it seems that the intercellular communication by specialized low resistant junctions is reduced in the deepest layers of the psoriatic epidermis. In the upper epidermal layers, however, the extensive formation and the variable configuration of the nexus express a high synthetic activity and a well developed intercellular information in these areas of the psoriatic epidermis.

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Demonstration of giant and anular nexus in the psoriatic epidermis

Mahrle

1978

Arch Dermatol Res

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So-called annular gap junctions in bone cells of normal mice

Marquart

1977

Experientia

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Spherical bodies consisting of a granular matrix and a pentalaminar limiting membrane were found in cells from the proximal tibial metaphysis of normal mice. The structures measured about 280-570 min in diameter and were located mainly in the cytoplasm of osteoblasts and occasionally in preosteoblasts. The granules within the bodies resembled ribosomes. The multi-layered composition of the limiting body membrane was identical with that of intercellular gap junctions.

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Variable Conformation of GAP Junctions Linking Bone Cells: A Transmission Electron Microscopic Study of Linear, Stacked Linear, Curvilinear, Oval, and Annular Junctions

Shapiro¹

1997

Calcif Tissue Int

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There is a marked variability in the conformation of bone cell gap junctions in newborn murine cortical bone as defined by transmission electron microscopy (TEM). Studies were done in newborn BALB/c mouse and Sprague-Dawley rat femurs and tibias. Femoral and tibial cortices were dissected into 1 mm3 fragments and prepared in standardized fashion using modified Karnovsky fixation, 7.5% EDTA decalcification, 1% osmium tetroxide-sym collidine buffer with 1% lanthanum nitrate postfixation, Epon resin, 60 nm sections, lead citrate/uranyl acetate staining, and examination at 60 kV. Previous TEM descriptions of bone junctions have, with rare exceptions, noted only isolated linear or mildly curvilinear structures. In this study we noted gap junctional shapes on thin-section TEM preparations of osteoblasts and osteocytes to be extremely variable and complex encompassing linear, curvilinear, stacked linear, oval, and annular conformations. Multiple observations revealed linear gap junctions linking surface osteoblast cell bodies; linear, curvilinear, stacked linear, and oval junctions linking osteoblast processes in osteoid; linear and curvilinear junctions where cell processes joined with osteocyte cell bodies and each of the five conformations linking osteocyte processes within canaliculi. The annular junctions were found within osteoblast and osteocyte cytoplasm and in osteocyte cell processes within canaliculi. The annular junctions are intracellular, degenerating structures which appear as ultrastructural markers of gap junction involution. The more complex shapes reported here must be considered in (1) interpreting quantitative studies using freeze-fracture replicas, thin sections, and confocal microscopy immunolabeled junction connexin-43 components and (2) assessing gap junction biogenesis and turnover. 3-D reconstruction of bone junctions will enhance our understanding of these complex conformations.

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An unusual membrane‐bound body in rat periosteal cells

Abstract: Cytoplasmic inclusions have been found in both normal and stimulated rat periosteal cells. These inclusions are bounded by a pentilaminar membrane similar to a tight junction and contain a core of granular material. The origin and function of this inclusion are unknown.

Cited by 4 publications

References 14 publications

Demonstration of giant and anular nexus in the psoriatic epidermis

Demonstration of giant and anular nexus in the psoriatic epidermis

So-called annular gap junctions in bone cells of normal mice

Variable Conformation of GAP Junctions Linking Bone Cells: A Transmission Electron Microscopic Study of Linear, Stacked Linear, Curvilinear, Oval, and Annular Junctions

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