An Unusual Morphologic Form of Hepatic Amyloidosis in a Goat

Abstract

In hepatic amyloidosis, amyloid deposition is usually perireticular, within the space of Disse, and appears as a homogeneous to faintly fibrillar material which lines the sinusoids, compressing the hepatic cords and narrowing adjacent sinusoids. This is a report of caprine hepatic amyloidosis in which the amyloid was deposited in a globular form within sinusoids. Sections of liver, kidney, gall bladder, lung, and stomach were submitted to the Department of Veterinary Pathology, Armed Forces Institute of Pathology, in May, 1983, from the Maryland State Animal Health Laboratory for assessment of an unusual globular crystalline deposition within the liver. The adult, neutered male goat, of undetermined age, had been part of an experimental protocol at the Frederick Cancer

Chronic arthritis and systemic amyloidosis in three goat kids associated with seroconversion to Erysipelothrix rhusiopathiae

“…The amyloidosis seen in these goats is of interest, probably accounting for intestinal malabsorption and hence the diarrhoea of goat B and a protein losing nephropathy as indicated by the renal pathology. The nature of the hepatic amyloidosis is similar to that described by Farnsworth and Miller (1985) in goats and is akin to human hepatic globular amyloidosis. Most cases of amyloidosis in domestic animals are idiopathic but appear to be of the reactive systemic type as a result of chronic antigenic stimulation (Maxie 1993).…”

Pathology of AA Amyloidosis in Domestic Sheep and Goats

“…6 Some sheep that were experimentally inoculated to obtain hyperimmune sera and a goat that suffered numerous protein inoculations also developed amyloidosis. 9,13 Remarkably, the only detailed study on reactive amyloidosis in small ruminants was done in wild bighorn sheep and in captive Dall sheep, where a pathologic condition similar to the one described in this study was presented. 11,18,45 We found in our sheep and goat that, as previously observed in these species as well as in cows, 16,18,26,33,39 bighorn sheep, 11 and Dorcas gazelles, 32 the organ most involved was the kidney.…”

“…34 Among small ruminants, AA amyloidosis has been reported in wild bighorn sheep (Ovis canadensis) 11 and Dall sheep (Ovis dalli); 18 however, descriptions in domestic sheep 72 Vet Pathol 40:1, 2003 Ménsua, Carrasco, Bautista, Biescas, Fernández, Murphy, Weiss, Solomon, and Luján and goats are rare and normally refer to single cases. 6,9,15,33,39 Remarkably, systemic amyloidosis in small ruminants has been diagnosed at the Veterinary Faculty of Zaragoza for decades, and it is relatively common. The objectives of the present study are to: 1) describe the salient pathologic features of spontaneous, systemic AA amyloidosis in domestic sheep and goats, and 2) establish immunohistochemically and chemically the AA nature of the amyloid deposits.…”

Pathology of AA Amyloidosis in Domestic Sheep and Goats

“…6 Some sheep that were experimentally inoculated to obtain hyperimmune sera and a goat that suffered numerous protein inoculations also developed amyloidosis. 9,13 Remarkably, the only detailed study on reactive amyloidosis in small rumi-nants was done in wild bighorn sheep and in captive Dall sheep, where a pathologic condition similar to the one described in this study was presented. 11,18,45 We found in our sheep and goat that, as previously observed in these species as well as in cows, 16,18,26,33,39 bighorn sheep, 11 and Dorcas gazelles, 32 the organ most involved was the kidney.…”

“…34 Among small ruminants, AA amyloidosis has been reported in wild bighorn sheep (Ovis canadensis) 11 and Dall sheep (Ovis dalli); 18 however, descriptions in domestic sheep Ménsua, Carrasco, Bautista, Biescas, Fernández, Murphy, Weiss, Solomon, and Luján and goats are rare and normally refer to single cases. 6,9,15,33,39 Remarkably, systemic amyloidosis in small ruminants has been diagnosed at the Veterinary Faculty of Zaragoza for decades, and it is relatively common. The objectives of the present study are to: 1) describe the salient pathologic features of spontaneous, systemic AA amyloidosis in domestic sheep and goats, and 2) establish immunohistochemically and chemically the AA nature of the amyloid deposits.…”