An unusual occurrence of gastric adenocarcinoma in pemphigus vulgaris

Gül, Ülker; Gönül, Müzeyyen; Soylu, Seçil; Heper, Aylın Okçu; Demiriz, Murat

doi:10.1111/j.1365-4632.2009.04091.x

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…In some BP cases, tumor resection led to complete recovery [36] supporting the thesis of close interrelation of the diseases. Gastrointestinal tumors have been reported in association with BP [17,37], PNP [38], pemphigus vegetans [39], PV [40][41][42][43][44][45] and MMP [46] sometimes with post-excisional remission [47,48]. Both chronic leukemia and lymphoma have been reported with DH [49][50][51] and PNP [52][53][54].…”

Section: Malignancies Associated With Abdmentioning

confidence: 99%

Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects

Pietkiewicz¹,

Gornowicz‐Porowska²,

Dmochowska³

et al. 2013

Highlights in Skin Cancer

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Section: Malignancies Associated With Abdmentioning

confidence: 99%

Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects

Pietkiewicz¹,

Gornowicz‐Porowska²,

Dmochowska³

et al. 2013

Highlights in Skin Cancer

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“…The manifestations can predate, occur at the same time or after the diagnosis of cancer. Associations with gastric cancer have only been reported twice [1,2]. Associations with other malignancies such breast, colon and bladder cancers have been reported [3].…”

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confidence: 99%

Gastric Cancer and Paraneoplastic Pemphigus

2015

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Paraneoplastic pemphigus is a relatively rare but significant acquired autoimmune mucocutaneous disorder that is characterised by diffuse erythema, painful blistering and sores of the skin and mucus membranes. The underlying pathogenesis is believed to be triggered by altered immune system in response to underlying neoplasm. The manifestations can predate, occur at the same time or after the diagnosis of cancer. Associations with gastric cancer have only been reported twice. A 78-year-old lady presented with a month's history of extensive skin lesions that started off as bullous lesions and biopsy revealed bullous pemphigus. Endoscopy for anemia revealed gastric cancer. This case reinforced the need to consider underlying malignancy in elderly patient with new onset dermatological presentation. Keywords Gastric cancer . Pemphigus vulgaris . Paraneoplastic manifestations . Bullous dermatological lesionsA 78-year-old lady presented with a month's history of extensive skin lesions that started off as bullous lesions. She had anorexia of recent onset but without any significant weight loss. Physical examination revealed multiple ruptured lesions throughout body (Fig. 1a) (trunk, genitalia and the extremities) with exudative discharge and bleeding. She also had painful lesions around the lip. Laboratory investigations revealed normocytic anemia of 7.3 g/dl. A skin biopsy showed ulcerated skin lesion lined by a layer of discohesive basal cells and direct immunofluorescence study showed pericellular positive staining for IgG consistent with pemphigus vulgaris (Fig. 1b, c). An upper gastrointestinal endoscopy showed diffuse esophageal candidiasis and multiple small geographic ulcers in the antrum (type IIc+a) (Fig. 1d). The biopsies of the antral ulcers showed diffuse infiltrating signet cell adenocarcinoma. Serum anti-desmoglin 3 was positive. A diagnosis of paraneoplastic pemphigus with the gastric cancer was made. A staging computed tomography scan revealed no metastases or any other abnormalities. Despite repeated discussions, the patient declined surgical intervention. She was managed with immunosuppressive therapy with some improvement of the skin condition. Her condition worsened and she passed away almost 2 years after the initial presentation.Paraneoplastic pemphigus is a relatively rare but significant acquired autoimmune mucocutaneous disorder that is characterised by diffuse erythema, painful blistering and sores of the skin and mucus membranes. The underlying pathogenesis is believed to be triggered by altered immune system in response to underlying neoplasm. The manifestations can predate, occur at the same time or after the diagnosis of cancer. Associations with gastric cancer have only been reported twice [1,2]. Associations with other malignancies such breast, colon and bladder cancers have been reported [3]. Other paraneoplastic cutaneous manifestations associated with gastric malignancies include Leser-Trelat syndrome, palmo-plantar keratoderma, acanthosis nigricans and paraneoplastic dermato...

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Acral manifestations of paraneoplastic and collagen vascular diseases

Gül

2017

Clinics in Dermatology

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An unusual occurrence of gastric adenocarcinoma in pemphigus vulgaris

Cited by 3 publications

References 6 publications

Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects

Malignancy in Relation to Autoimmune Blistering Dermatoses: Molecular and Clinical Aspects

Gastric Cancer and Paraneoplastic Pemphigus

Acral manifestations of paraneoplastic and collagen vascular diseases

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