An Unusual Presentation of Burkitt Lymphoma

Vu, H.; Vildor, Esther; Reddy, Shilpa; Phillips, James A.; Meenrajan, Senthil; Edwards, Linda H.; Hosenpud, Janet

doi:10.1097/smj.0b013e3181b08d9c

Cited by 3 publications

(4 citation statements)

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“…In the current study, EBV was detected in18 out of 19 (95% ) in eBL and in 42 out of 60 (70%) in control cases (significant association , p < 0.05) ( Fig. 2) and in 8 out of 41 (20%) of the sBL (no significant association , p > 0.05), ( Fig.3).These findings were consistent with previous studies from United States (1,2) that found EBV was present in the majority of endemic cases of BL (up to 100%) and in only 15% to 30% of sporadic cases and also similar to other studies from Europe (29) , northeast of Brazil (17,33) , Africa (34) ,Argentina &Chile (35,36) , and Iran (8) . In contrary to our results, studies from Southeast and Central West regions of brazil (7,35,37,38) that obtained different frequencies of association between BL and EBV, varying from 50% to 72%.…”

Section: Groups Endemic Sporadic Controlsupporting

confidence: 91%

“…The population living in the southeast enjoys a higher standard of living compared to that in the northeast (29,39,40 ) . Our explanation regarding the different rates of EBV association between endemic BL and sporadic BL was supported by recent studies from southeast of Brazil that showed in industrialized countries, seroconversion occurs during the first 2 or 3 decades of life a low association of EBV (34,41) and to previous studies from Uganda (42) that showed100% of children are EBV-seropositive before the age of 3, and a correlation between age at seroconversion and socioeconomic status was documented many years ago. We Concluded that there were a statistically significant relationship between endemic BL and detection of EBV DNA by the PCR method supported the an important role of EBV in the pathogenesis of pediatric classical endemic BL in Iraq.…”

Section: Al-anbar Medical Journalsupporting

confidence: 80%

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Association Between Epstein-Barr Virus and Burkitt’s lymphoma in Western Iraq. (A molecular case-control study)

2016

Al-Anbar Medical Journal

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Introduction: urkitt's Lymphoma(also called small non cleaved cell lymphoma) is a highly aggressive non-Hodgkin lymphoma with an incidence of 2-3 cases per million per year in USA (1,2) .While in the African equatorial belt the incidence is 5-10/100000 for endemic BLand the children accounts for up to 74% of childhood malignancies (3). However, Indian studies ranked BL only third in frequency among children following precursor T-lymphoblastic lymphoma and DLBCL (4). The disease is characterized by tumors of the jaw bones and abdomen (5) .There are three subtypes of Burkitts lymphoma: endemic Burkitt's lymphoma (eBL), sporadic Burkitt's lymphoma (sBL), and immunodeficiency-associated Burkitt's lymphoma, these show marked variation across different geographical regions with respect to age, primary tumor site and B Background: Association of EBV with BL is differ according to the geographical distribution and type of BL with a consistent C-MYC chromosomal translocation. Objectives: The purpose of this study is to find out the association between Epstein Barr virus & the characteristic C-MYC as well as the age and gender distribution of Burkitt's lymphoma in Western Iraq. Patients and Methods: In this case-control study we have analyzed paraffin sections from 60 patients with Burkitt's lymphoma (19 endemic BL, 41sporadic BL). Diagnosis of these cases was depend on clinical and histological as well as immunohistochemical bases. Detection of Epstein-Barr virus (EBV) DNA and C-MYC chromosomal translocation by PCRwere performed, using sets of primers flanking the EBNA-1 and the c-MYC chromosomal translocation. Results: Endemic BL affected mostly children aged 3-10 years (mean age: 5.6 years), whereas sporadic BL affected mostly adults aged 22-37 years(mean age:29 years). The sex ratio of the BL was 2:1 (41M: 19F).Study showed that 18/19 of endemic BL and 8/41 of sporadic BL were positive for EBV(positive EBNA1 by PCR).C-MYC chromosomal translocation was detected in 18/19 endemic BL and in 40/41sporadic BL. Conclusions: There was significant association between EBV and endemic BL but no such a relation with sporadic BL. Also there was a strong association between C-MYC translocation in both endemic and sporadic BL. However there was no significant correlation between C-MYC translocation of endemic & sporadic BL and the gender.

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Section: Groups Endemic Sporadic Controlsupporting

confidence: 91%

Section: Al-anbar Medical Journalsupporting

confidence: 80%

Association Between Epstein-Barr Virus and Burkitt’s lymphoma in Western Iraq. (A molecular case-control study)

2016

Al-Anbar Medical Journal

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“…In addition, the presence of antibodies against Epstein-Barr antigens has been associated with the development of African-type BL [3]. In the sporadic form of the disease that occurs worldwide in non-endemic areas, mostly in developed countries, patients present with an abdominal mass that frequently involves the ileocecum in the bowel [4], whereas ocular or orbital involvement is rare [5]. According to a 2012 analysis of the Georgian population, BL is uncommon, and only 47 cases of nodular and 181 cases of diffuse non-Hodgkin lymphoma have been registered [6].…”

Section: Introductionmentioning

confidence: 99%

Orbital Burkitt lymphoma: a case presentation

Alexander¹,

George²,

Tinatin³

et al. 2014

BMC Ophthalmol

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BackgroundHighly aggressive Burkitt lymphoma (BL) with rapidly progressive painful proptosis of the right eye is rarely encountered.Case presentationA 31-year-old Caucasian female presented with rapidly progressive painful proptosis of the right eye and poor visual acuity. Diagnostic Computer tomography, magnetic resonance imagining and angiography, identified an oval-shaped mass on the medial rectus of the right orbit that caused dislocation of eyeball, for which she underwent medial orbitotomy. The mass was histologically confirmed as BL, and postoperative aggressive chemotherapy (BFM-90) was initiated. BFM-90 reduced the recurrence of strabismus, diplopia, and proptosis, but did not correct deficits in the best corrected visual acuity.ConclusionIn patients presenting with painful proptosis and vision loss, a diagnosis of BL should be considered. In addition, because of the rapid progression of BL, and considering that it responds well to treatment, a diagnostic work-up including a tissue biopsy should be initiated immediately if BL is suspected.

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“…BL is endemic in certain regions of equatorial Africa, where it commonly involves facial bones, such as the mandible, maxilla and orbit, and can invade adjacent orbital soft tissue structures, such as the eye [3,4]. In the sporadic form of the disease that occurs in non-endemic areas around the world, most commonly in developed countries, patients usually present with an abdominal mass that frequently involves the ileocecal region of the bowel [5]; ocular or orbital involvement is rare [6]. Primary disease of the sinuses is uncommon and, to the best of our knowledge, that of the anterior septum has never been described.…”

Section: Introductionmentioning

confidence: 99%

Unusual presentation of sporadic Burkitt’s lymphoma originating from the nasal septum: a case report

Aslan

2013

J Med Case Reports

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IntroductionBurkitt’s lymphoma is a highly aggressive, small, non-cleaved B-cell non-Hodgkin's lymphoma. In the sporadic form of the disease that occurs in non-endemic areas around the world, most commonly in developed countries, patients usually present with an abdominal mass that frequently involves the ileocecal region of the bowel; ocular or orbital involvement is rare. Primary disease of the sinuses is uncommon and, to the best of our knowledge, that of the anterior septum has never been described. We report the diagnosis and successful management of Burkitt’s lymphoma originating from the nasal septum in a male patient.Case presentationAn otherwise healthy 78-year-old Caucasian man who did not smoke cigarettes was admitted to our Ear, Nose and Throat outpatient clinic with the complaint of nasal obstruction due to left-sided nasal septal thickening. Paranasal computerized tomography revealed a well-circumscribed solid mass originating from his anterior nasal septum and obstructing his airway. The final diagnosis of Burkitt’s lymphoma was verified by immunohistochemical studies. Our patient had a good clinical outcome after chemoradiotherapy, with no problems reported to date in the second year of follow-up.ConclusionWe provide what we believe to be the first report of a case of sporadic Burkitt’s lymphoma involving the nasal septum, and describe the efficacy of first-line chemotherapy. Being an original case report with broader clinical impact across more than one area of medicine, this case presentation has the potential to significantly advance our understanding of Burkitt’s lymphoma and we emphasize the need to include this disease in the differential diagnosis of patients presenting with a nasal septal mass.

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An Unusual Presentation of Burkitt Lymphoma

Abstract: We describe a 37-year-old non-smoker who presented with dyspnea and a unilateral effusion secondary to Burkitt lymphoma (BL). The diagnosis was made by pleural tissue biopsy using video-assisted thoracoscopic surgery (VATS). Burkitt lymphoma is discussed.

Cited by 3 publications

References 4 publications

Association Between Epstein-Barr Virus and Burkitt’s lymphoma in Western Iraq. (A molecular case-control study)

Association Between Epstein-Barr Virus and Burkitt’s lymphoma in Western Iraq. (A molecular case-control study)

Orbital Burkitt lymphoma: a case presentation

Unusual presentation of sporadic Burkitt’s lymphoma originating from the nasal septum: a case report

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